Arginine WARNING

[Tnyvnd]

doctor what is nitro stress? and does your body build up long term tolerence to these nitric oxide argenine pre workout's i tend to cycle off for months at a time due to assure my body natural production is not affected and i would like to learn more

[rockcityaudio]

creatine, arginine and caffeine.=death.

[RyanJohnston1507]

why would I believe this video when who ever did this cant spell "Warning" at 0:56

[weightlifter210]

this is the only video i found saying l arginine is bad for you. Dr ignarro says ur wrong. Why does l arginine make me feel good? because its doing good things in the body. Its cheaper the all the heart drugs the doctors push u to take. To me a doctor is just a legal drug dealer.

[smoothroca]

Just keep sitting on the couch. If you had any clue on fitness science you wouldn't be making this hypocrisy of a video! I agree with tbeck1967 100%

[hawkfeather68]

While I can understand a warning for overdoing everything, I'm sorry doc, I cannot get every word you are saying, maybe it's the sound in the video? The other thing I noticed is that when you are speaking you are scratching your nose, a sign of you are not fully in agreement with something you've stated. I think anyone that wants to take supplements should discuss it with their doc. With having only one kidney that functions, I'm doing research before taking anything. That means BOTH sides.

[auggiedoggy]

@hawkfeather68 : Or perhaps his nose is itchy! Duh!

[PureBrutalSickness]

this is only when taken in large amounts we should take around from 4 to 9 grams of arginine a day.. deepens on your activity level..

[SamuelDurkin]

I used a mild dose (500mg) of this each day after a heart failure (AF), and am now well again, I'm now stronger and fitter then men half my age.

[winintheflop06]

What a bunch off bull, his statements are that of his own beliefs and not that of scientific theory. Arginine is proven to help deliver nutrients to the cell quicker. Don't listen to this moron.

[Julviano]

Dear Dr. your claims are widely exagerated. Arginine MAY cause nitrosative stress and oxydative damage if administered long term and in huge quantities. Arginine and NO supplementation cause vasodilation ind improve the circulatory system by "opening" and softening the blood vessels enabling the blood to circulate better thus reducing blood presure and plaque build up.

[MrAiden0909]

This could be correct. The arginine the maybe talking about is synthetic arginine. Arginine I used is proven by Dr. Louis Ignarro who talks about arginine serving no more heart disease. You can take proven pharmaceutical l-argine after heart attack and to prevent cardiovascular disease.

[sosaj64]

@MrAiden0909 DO NOT DO THIS. Don't take after a heart attack, there was a study with people taking arginine after a HA and died, stopping the study. Not saying don't take arginine,(I take it) just not after a heart attack

[harrisezzat]

All of your research is based off of those "special cases" while its been proven that arginine is widely known to work for the general population. Unless you show real BELIEVABLE and credible evidence that arginine is harmful such as a meta-analysis, I and other educated viewers refuse to believe this.

[be4realyo]

I'm still sticking with my N.O. yo

[oiyabastard]

GAY MUSIC AND BACON SANDWICH IN THE MORNING IS NASTY

[st8ofgrind]

hes right but wut hes not telling u is if you take anti oxidants and take small doses of arginine with exercise you'll be fine. NO is radioactive look it up

[mscoppin]

Clinical studies do not lie. Where did you get your information. 1960's.

[Skipper466]

I googled it and found some clinical studies where L-arginine supplementation was used to alleviate symptoms of copd. I tried to post one of the links but it was too long.

[jerrysounds]

Dr.Ignarro the leading expert on Nitric oxide and its roll in the human body, is saying the exact opposite. He has won the Nobel Prize for his work on the subject. Who is this dude? I call, BS!!

[nature2rule]

Doc, you ask, "who lies? top scientists or the companies selling arginine for quick profit." MY ANSWER: Bogus "top" scientists, funded by the billion dollar pharmaceutical companies.

[OKzs]

Uh this is in my protien power which I take all the time & in my BCAA pills - yikes

[prozanine]

notice how the more you listen to doctors, the sicker you seem to get, but remember its not the big pharm drugs, its all in your head.

[menderfire9]

This video is talking about the possible dangers of taking LARGE AMOUNTS of arginine. Dr. Ignarro did NOT say anything about which lab, which brand, which size or anything else regarding taking arginine. Many products we can purchase at Walgreen's or our gym of choice are created, sold, and taken very irresponsibly whether through ignorance, thoughtlessness or denial of damage they could cause through overuse or abuse. Amen.

[xGLAVONJAx]

What does he know ? He didn't win the Nobel Price DR Ignarro did ;-) a leading researcher on Nitric Oxide...this guy is wrong

[SLIMS619]

TRUE!!

[F0ckUtoob]

uhm, well. I take it & notice I can build muscle & burn fat VERY fast. But that might be my metabolism working w/ L-Arginine. I also use it for migraines & the fact that with sleep it's supposed to release anti aging hormone

When I worked, & I mean work, not sitting behind a desk, I mean cutting trees all day I noticed I built muscle VERY fast felt VERY good & thought the fat was burning off me. Now that I am not working as much I do take less though b/c our body only uses what it needs anyway

[sandbar3000]

Something else that I learned about this "wonder" amino acid - ha ha ha - it not only FEEDS cold score growth - it makes those with schizophrenia WORSE. Look at this website and read the bottom of the page. This amino acid should have never be produced by our body. L-Lysine should be produced in the body since Lysine has much more health benefits!

[jopalo31675]

Thats very interesting, thanks for the info. Where can I find more on this.

[sandbar3000]

oh damn. I didn't provide the link! I'll have to go look for it. I just googled "Arginine". I'll look for it. You could do a boolean search by typing in "Arginine and cold sores" or Arginine and schizophrenia".

[hey78huy]

Funny we don't see "doctors" making YouTube warnings about toxic and deadly pharmaceuticals, only natural compounds found in the body and other things like "apricot seeds are deadly (bullshit)" or "There are no scientific results to prove vitamin C is good for colds!". When you have a state license to do what you do, you are in essense, an agent of that State. Since government is in bed with the FDA, they only attack supplements, never bad drugs and vaccines.

[hey78huy]

On another note, instead of wasting time with L- Arginine and the controversy, talk about fresh garlic, ginger root, hawthorne berry, cayanne pepper, grapefruit, and others which have been used for centuries for boosting circulation, melting arterial plaque and protecting the heart muscle during heart attack by slowing damage and need for oxygen until help arrives. There are so many other natural compounds with a much longer history of use and effectiveness.

[sandbar3000]

I'd rather have all that food and never have any arginine. I hate arginine.

[Jecxbox]

exactly

[GetHealthyB4TooLate]

So what is a safe amount? It has its benefits too. Like my Dad has a blockage and this is supposed to melt it away.

So what is a "SAFE" amount to take?

[tbeck1967]

We have been taking between 7grams, (7,000mg) to 10grams (10,000mg) of ProArgi9 Plus a day and are feeling fantastic. I am 42 years old and caring for my mother who is 75. She has had a Stroke, triple bypass, 2 hip replacements, Anemea,Arthritis,type2 diabetis,Osteoporosis,shingles­,depression, you name it she's had it. She now has the bloodpressure of a 20year old and is getting younger everyday. As for myself,I too am feeling ontop of the world. It will disolve your dads plaque,&save his life..

[Jecxbox]

thanks for your comments

[FatBrokeandStupid]

tbeck is right. I am 49 and have started training heavily for a promotional boxing match thanks to L-arginine in the form of Proargi9. This stuff works...shut up and try it yourself instead of dirt bagging something you know nothing about.

[tbeck1967]

If you do a bit of research you will find that our good Dr Clayton has a very keen interest in pushing pharmaceutical products as he is a member of the London pharmaceutical chains and if there was found to be a product that could cure thousands of symtoms then Dr Clayton and associates would themselves come down with a disease called Loosing money Syndrome. I have been on L-Arginine (ProArgi9 plus) for years now,and love it. 35 years of real research + thousands of documented cases. DYOR

[GorillaBaps]

tbeck1967: Check Dr. Ignarro's wikipedia page: It states that Nitric Oxide is toxic at high doses so I bet he doesn't encourage loading up. Don't forget, Doc. Clayton was referring to tanking up on L-Arginine so he wasn't slating it outright.....just to exercise caution if you're hammering it. If it works 4 u, then great. I took it short-term after an op. once to improve wound healing.

[GorillaBaps]

Well, I'd be interested to read about Dr. Clayton pushing pharma. products because everything I read of his states the opposite: He pushes good nutrition as preventative medicine so he is highly opposed to reliance on chemical pharmaceuticals. He has written a book on the limitations of drugs: Pharmageddon so I'd be very suprised to learn he'd been endorsing drug products. He engineered the high-end supplement complex, the food-based Nutrishield which is streets ahead of most suppl. programs.

[GorillaBaps]

I don't know much about Dr. Ignarro but his wikipedia page mentions he has made a tidy sum working with Herbalife, yes that company with its Self-Motivation Conferences and Pyramid Marketing Schemes.....need I say more?

[r10tpump]

@tbeck1967 lmao, i love it you are dead on bro big pharm, is the anti christ great post bro.

[GetHealthyB4TooLate]

How much is too much, and why is Dr. Louis Ignarro, who won a Nobel Price, promoting it?

Thank you.

[GorillaBaps]

So did Barack Obama.....nice guy but he's been in Office for all of 1 year..! Hence, Nobel Awards can be presented on a 'still-to-prove' basis.

[topgo1fer]

Does this Doctor really believe He can guess he believes Arginine is dangerous.

where is his proof where are his case studies Perhaps he believes he doesn't require any proof just his opinion rather like his quote of bacon sandwich rather nice after the night before perhaps he believes drinking alcohol is not harmful, when infact it is one of the biggest killers in our society today

[GorillaBaps]

Yeah, I think you're reading into that Bacon Sandwich + Booze thing too much. "Once in a while is fine" I think is what he meant , don't you? While there is still plenty of evidence of NO toxicity, does it really make sense to tank on it, long term? It's classed as a non-essential amino-acid and OK in moderation. Also, look at the reported side effects at Aboutdotcom - "What is l-arginine?" Your call..!

[teevee57]

Interesting the Doctor states what "He Believes." Where is the science in that? Over 75,000 articles on PubMed on Arginine benefits. I guess "HE BELIEVES' they are all wrong...

[DrPaulClayton]

Page 2 & 3 in the comments section I have given more details on the research on Arginine

[Baroncoma]

Please explain, then, why your medical opinion is different than the results of the High Desert Study, in Palo Alto California. Your comments also seem to go against the opinions of Dr. Ignarro & Dr. Prendergast. Can you clarify if you're only referring to L-Arginine alone or how we would use it, in combination with L-Citraline?

[Taoistimmortal]

@DrPaulClayton

Dude, You are not even a medical Doctor. You've done no clinical experiment, well you are not even qualified to do so anyway. You are talking right from your backside. Try to attract people to buy your book? No fat chance... Shame on you!!!!

[swimmer4ever200687]

@teevee57

more than that there are nobel prize winners who win thier nobel in discovering how arginine is good for NO in your body and that lowers high blood pressure and prevent and may be reverse cardial problems :) .

[FeelNFine]

@swimmer4ever200687 Bullshit, it was purely about NO, and all of the sites who reference the 1998 prize say NO is good, this IS BROKEN DOWN INTO NITROUS OXIDE, therefore this is good for you.

[gotilk]

I have never heard of anyone claiming it would be a good idea to take mega-doses of Arginine without taking significant time off between cycles of mega-doses. I make no suggestions, but would say that I usually take it for 5 days, followed by at least 14 days off. Always only at bedtime on an empty stomach, not multiple times a day. What this video claims has meaning only in the context of chronic use of large, daily divided doses. ONLY. Hype comes from both directions.

[PrinceMio49]

Every time I go to the Dr. they have their prescription pad in hand. It seems to me they are getting profit on what drugs they can prescribe.

I was on a drug for high blood pressure, which had side effects, right now I have 122/68, heart rate 56 bpm, lower than when I was on the drug.

I can understand why supplements are illadvised by Dr's. The real risk is no profit.

[rifetf]

can have eny risk if i take l-arginin 400mg and l-ornithine400mg for work out

[ghostbow]

Trying to outsmart our bodies with isolated nutrients, especially in high doses, will always be a risky business. The natural world has it's reasons and operating principals. Violating them has consequences.

[petestrat07]

ghostbow-Living in the "natural world" in the true sense means that the human being had to rely on the vitamins/nutrients that were found within close range of where they lived. Therefore, nutritionwise they were limited to what their environment could supply. IMHO I see nothing wrong with isolated nutrients.For example I take Kelp for its nutrition/health promoting properties but I've never gone deep sea diving to collect it.

Unless of course you are talking about the refining of protein.

[SophosVII]

that is now what he mean, taking kelp and taking Arguinine are two separate things. Truth is that right after somebody come out and say this or that "MIGHT" help here or there, people immediately take it as a fact and a bunch or people start to sell them in pill or w/e before the propper studies have been conducted.

[petestrat07]

I'm not "people" and I am not taking arginine coz it "might" be good for me.

I'm taking it for bodybuilding purposes along with a lot of other vitamins and minerals and I am just stating that people can benifit from supplements instead of eating a thousands of different types of food. I need to know how many grams of carbs/proteins and fats I eat each day so a simple diet makes sense for me. Sure people get easily mislead but thats why each individual needs to do reasearch before consuming.

[gleamingauction]

please add com after ijcep. to find the link

[gleamingauction]

ijcep./files/IJCEP808005.pdf

[gleamingauction]

Thanks very much again Dr Clayton, but would there be a risk with contracting alzheimer's disease even with usage of small dosages such as 2 grams daily?

I highly respect your opinion on this matter, however I would like to see some medical research or results from clinical trials before making a judgement on these side effects. I did manage to find the following journal which supports your assertion to an extent, however I am still not totally convinced until I can gather more evidence.

[Cr4zYH3aD]

waht about pre-workout bodybuilding product ? They contains creatine, arginine and caffeine.

[DrPaulClayton]

Please see the facts listed below -and make your choice.

The risk is yours

[jreily88]

@Cr4zYH3aD

Yes, those work very well. It's only when you have a super high dosage of arginine that you start seeing negative side effects. Arginine has been extensively shown to help with heart disease. Also, it's a natural occuring amino acid that's made in the body.

[igeremind]

Lies.

[DrPaulClayton]

Who LIES ?

Top Scientists or the Companies selling arginine for a 'quick' profit.

This is the research information you have your choice

[teevee57]

When you speak of Top Scientist I assume you are excluding Nobel Prize winners who won a prize for their research regarding arginine and the nitric oxide pathway and including such "top scientist" who have brought us the "miracles" of zetia and vytorin.

[gleamingauction]

Lastly, would there be a point when your body would stop responding to arginine if and when it would get used to the same dosage, and in this case would one need to increase the dosage of argine to obtain the desired results or start to cycle arginine?

[DrPaulClayton]

Many thanks for your question about arginine which is a nutrient that should, in my view, be used with caution.

I believe that it is highly probable that excessive doses of arginine will, over the years, contribute to those pathologies which have a nitrosative stress component, such as Alzheimer's Disease. The companies that sell arginine have failed to disprove this, although admittedly it would be hard for them to do so.

[DrPaulClayton]

They rely on selling their product's short-term benefits - such as relief of intermittent claudication - and down-playing any concerns about the long term health risks of their product.

I have spoken about this with a number of senior scientists who work in the Alzheimer's area, and I think it is fair to say that the majority share my concerns about arginine.

[DrPaulClayton]

The historical problem is that this amino acid was originally picked up by a couple of cardiologists who knew nothing about neuro-degenerative disease.

[DrPaulClayton]

I don't know why you are taking arginine, but if it is for vascular reasons you will do better with high dose flavonoids. They do not act as rapidly, but unlike arginine they get to the root of the matter (endothelial dysfunction), and rectify it. This effectively removes the underlying cause of both hypertension and atheromatous disease.

I hope this helps.

[gleamingauction]

Dr Clayton,

Many thanks for the info. You mention in your video that excessive amounts could be detrimental and induce nitrosative stress in the body, in light of this what is your opinion on an arginine consumption of 1-2 gms daily in the form of tablets?

Would there be any adverse effects of long term use of arginine, say for a period of 5 years using the aforementioned daily dosage of 1-2 gms?

[DrPaulClayton]

Please see above for details

[bongojim]

And you can draw a linear conclusion between nitrates in cured meats and nitric acid via arginine supplimentation...how?

[eternalbliss47]

How can you say that? Any research?

[UniViteHealthcare]

The Mayo Clinic web page on L-arginine reports that it can increase lung inflammation and worsen asthma.

[edit]Growth hormone

Arginine increases the production of growth hormone.[9] Reports of its effects on male muscular development are not clearly proven.

[BlackSpade72]

only if you inhale the L-Arginine that will cuase the lung inflammation .

[UniViteHealthcare]

Information from The Mayo Clinic

'In theory, arginine may increase the risk of bleeding. Patients using anticoagulants (blood thinners) or antiplatelet drugs, or with underlying bleeding disorders, should speak with their qualified healthcare providers before using arginine and should be monitored.

Arginine may increase blood sugar levels. Caution is advised in patients taking prescription drugs to control sugar levels.

[PitoDaddy]

Dr. Louis Ignarro says just the opposite about  arginine. Who's telling the truth? This is confusing.

[DrPaulClayton]

In answer to your question about arginine, here are some of the facts ... Nitric oxide (NO) is an important messenger molecule in a variety of physiological systems. NO, a gas, is produced from L-arginine by different isoforms of nitric oxide synthase (NOS) and serves many normal physiological purposes, such as promoting vasodilation of blood vessels and mediating communication between nervous system cells.-

[DrPaulClayton]

In addition to its physiological actions, free radical activity of excessive amounts of NO can cause cellular damage through a phenomenon known as nitrosative stress.

NO has been shown to modify protein structure and therfore function by nitrosylation and nitrotyrosination, and this sort of protein reconfiguration ('mal-folding) is deeply implicated in Alzheimer's.

[DrPaulClayton]

Excessive NO also contributes to glutamate excitotoxicity, inhibit mitochondrial respiratory complexes, and participate in organelle fragmentation. This combination of adverse effects is strongly linked to a number of neuro-degenerative and other diseases.Louis Ignarro is, of course a Nobel laureate, primarily for his work that demonstrated that EDRF was NO, and I respect his work in this area.

[DrPaulClayton]

Nonetheless, I think he is wrong in saying that increased intakes of arginine (the substrate of NOS) always reduces nitrosative stress; if the body is being forced to make too much NO, which arginine loading tends to do, this is by definition nitrosative stress. See, for example, Huang HS, Ma MC, Chen J. Chronic L-arginine administration increases oxidative and nitrosative stress in rat hyperoxaluric kidneys and excessive crystal deposition. Am J Physiol Renal Physiol. 2008 Aug;295(2):F388-96.

[DrPaulClayton]

However, perhaps we should be a bit more subtle. The above paper shows that arginine leads to increased nitrosative stress in a model of disease, so perhaps arginine loading might be particularly prone to triggering nitrosative stress in situations where there is pre-existing stress or disease.

[DrPaulClayton]

This is supported by another paper in which arginine loading had opposite effects on NO production in challenged vs unchallenged rats; ie it was more likely to cause increased NO formation and hence nitrosative stress in the presence of other challenges. (Kolios G, Kotzampassi K, Manousou P, Paramythiotis D, Papanastasiou H, Drygiannakis I, Notas G, Tsagarakis N, Eleftheriadis E, Kouroumalis E.

[DrPaulClayton]

Enteral nutrition affects nitric oxide production in peripheral blood and liver after a postoperative lipopolysaccharide-induced endotoxemia in rats. Nutrition. 2007 Jul-Aug;23(7-8):575-81.).It also seems likely that the tendency of arginine loading to cause nitrosative stress is modified by other physiological and nutritional factors; the background REDOX state of the animal / person is probably also a factor (ie Chakraborti A, Gulati K, Ray A.

[DrPaulClayton]

Age related differences in stress-induced neurobehavioral responses in rats: modulation by antioxidants and nitrergic agents. Behav Brain Res. 2008 Dec 1;194(1):86-91.)

So this is why I disagree with Ignarro. This is not a perfect world, and the sad fact is that most adults today do have multiple micronutrient depletion, and as a result some form of degenerative pathology. And in this (dominant) set of people, chronic arginine loading is, on balance, likely to do more harm than good.

[MDIS]

What about taking arginine with anti-oxidants such as taurine , and vitamins?

I understood what Arginine could potentially and permanently do to our bodies but what do you recommend for us athletes both amateur and professional ?

I am not consuming arginine everyday but only on workout days.

[MDIS]

I have heard that Arginine produces poisonous gases that would be highly TOXIC to the brains and organs.

But could i take it with anti-oxidants and multi vitamins to curb it ?

I only take about 2gm .

[UniViteHealthcare]

Arginine may increase blood sugar levels. Caution is advised in patients taking prescription drugs to control sugar levels.

Arginine may increase potassium levels, especially in patients with liver disease.

L-arginine may worsen symptoms of sickle cell disease.

information -The Mayo Clinic web

[UniViteHealthcare]

info : The Mayo Clinic.

Arginine hydrochloride has a high chloride content and has been used to treat metabolic alkalosis. This use should be under the supervision of a qualified healthcare professional.

In general, most people do not need to take arginine supplements because the body usually produces enough.

[UniViteHealthcare]

Asthma

Although it has been suggested that arginine may treat asthma, studies in humans have actually found that arginine worsens inflammation in the lungs and contributes to asthma symptoms. Therefore, taking arginine by mouth or by inhalation is not recommended in people with asthma.

[UniViteHealthcare]

Allergies

A severe allergic reaction, called anaphylaxis, has occurred after arginine injections. People with known allergies should avoid arginine. Signs of allergy may include rash, itching, or shortness of breath.

[UniViteHealthcare]

Side Effects and Warnings

Arginine has been well tolerated by most people in studies lasting for up to six months, although there is a possibility of serious side effects in some people.

Stomach discomfort, including nausea, stomach cramps, or an increased number of stools, may occur. People with asthma may experience a worsening of symptoms, which may be related to allergy, if arginine is inhaled.