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  • If aging is basically a result of garbage interfering with normal cellular function, how difficult would it be to identify that garbage and create artificial "machinery" to specifically target aberrant components in the mitochondrial space and shuttle it out?

  • only time ever in history this sentence has benn uttered: ' a group from newcastle are leading the way' ;DDDDDDDD

  • My theory is that Aubrey is a reincarnated Enki who was an Annunaki 450,000 years ago. He helped create modern Human form , and has come back to give us back our birth right ....1000 year lifespan.

  • Aubrey De Grey!

    I will follow you in your crusade, my liege!

  • Aubrey's beard is rock on baby! I wonder when pondering solutions to humanities age old problems he strokes his beard and murmurs to himself mmmm aahhh mmmm hahaa etc etc - you get the picture - big long bearded guy strokes beard whilst, quite rightly so, looking remarkably clever and Godlike! Show me some thumbs if you are thinking - Rock on Aubrey! :-)

  • does anyone the reason behind the speaker having such a long beard? quite rare.

  • @MatrixOfDynamism He grows it to show that he isn't materialistic but rather someone that cares more about his work than his image.

  • When he said co-translational import at 0:50:25 I really hit myself that hadn't thought of that all the time. I learned about cotranslational import in 2006 (my first year ), I really should have thought of that when he was talking on and on about problems with transport. Dumb me!

  • 1 現象, 事象, 事件

    a historical phenomenon

    歴史的事象.

    2 《哲学》現象, 外象(⇔noumenon).

    3 (複〜s)((略式))特異な[並はずれた]事物[出来事];非­凡な人, 奇才

    a child phenomenon

    神童.

  • Why, when talking evolution and science do some dullards want to introduce their damn god? GTFOH...

  • if I hear or read the term "God Created" one more time, i'm going to clime through that persons internet connection, jump out from their computer screen and choke them to death!

  • Get him some Water!!!!!!

  • @411Bigboss What why? You think hes blazed?

  • @FriedrichWilhelAhmet you can tell he gets real thirsty while giving his presentation. it made me have to get something to drink.

  • @FriedrichWilhelAhmet LOL no hes saying so much that you can tell he needs some water.

  • aging is normal to a point. but getting old is not normal. i think we were ment to live forever.

  • aging is normal to a point. but getting old is not normal. i think we were ment to live forever.

  • In the bible, God created man in his image. Adam and eve then ate the fruit from the tree of the knowledge of good and evil. They didn't manage to lay their hands on the fruits from the tree of life. However, since mankind is equipped with knowledge, theoretically, we can also create the "tree of life" and "consume its fruits" as well.

  • @meltingEyeballs nice fairytale you got there. Who told you that? Your local child raping priests, before you went to bed?

  • @Hermoor Get an education. Meanwhile, Listerine will be a really good beverage for you.

  • @meltingEyeballs Where did you go to school, church? Churches are inahbited by bald virgins that due to bad excercise have lost the good blood circulation they were born with. The human body was evolved to be able to run from lions and bears. Not sit in a chair all day imagening virgins to be able to give birth to people that can walk on water. Get a life, real friends not imaginary. And start take care of your body and your mind...you are sadly not doing it judging from your body.

  • @meltingEyeballs God created man to live forever in paradice on earth. not die. its about ( forgive my spelling) Soverinty. Who has the right to rule? the Devil implecated God as a liar. telling Eve she would not die, but become like God. As if God was hiding something from them. So the Question was posed. who has the right to rule? whos kindom is superior Gods or Mans? there is an end to every exam or test. and we as people havent been getting any answers right. last thing u hear Pencils up!

  • This guy's counter-aging strategy requires the cure for cancer... we should probably be working on that first.

  • weird beard

  • I wonder why he doesn't do it on himself when he knows how to stop ageing? he looks far older than his age

  • To tell everyone the truth am getting addicted to Aubrey's voice. Makes me feel closer to indefinite lifespan. :-P

  • @buddhaburrito Go join the singularity university. We need ppl like u. Al the best. :-)

  • does anyone know when we will be able to be 'immortal' (so to speak ) im 20 years old so will it happen to me?

  • @BananaSandwich1 I suppose you have a very good chance for an indefinite lifespan

  • Aubrey de Grey fooled the World

  • Actually, Aubrey is actively involved in researching this. The SENS foundation is working on three of the seven types of damage he has identified. Have a look at his talk at Singularity University for something more recent.

  • What a jackass. If you are so smart then shave lol :)

  • QUESTION: If we were to defeat aging, by whatever process we find, and say live to 600 yrs, would those people, whomever they were, agree to be sterilized, so as to avoid over population? What say you?

  • have a shave man D

  • Is there is a thing of the pathology of the mind? It is the software that effects the body or macrocosm.

  • If I had money I would give it all to his research.

  • @Rusvi1 i just wish teh people who do have money would...

  • Mitochondrial condition is not the only causative agent in aging; for example, Dolly the cloned sheep suffered from premature aging. Dollys DNA came from a donor while Dollys mitochondria came from her surrogate mother, thus the cause of the aging was not the mitochondria but from the pre-aged donor DNA. Cause: maybe telomere shortening.

  • aging is a terminal illness that we are all born with.

  • and it will be cured.

  • He's a joke, he hasn't done any research and is all theory, he's got a complete theory on why we age but knows nothing on how to actually stop it.

  • @MikDonsen R u sure? :-)

  • @mayavi22 Am pretty sure he is not. Probably didn't check the SENS website and the new developmens in bioTech,nanoTech and other areas of research which indirectly help our cause of IL. :-)

  • @MikDonsen - How do U expect one to know the answer to a ? B4 they develop the ??

    First we must observe that aging exists -CHECK

    Then we must decide we don't like it -CHECK

    Then we must decide to end it - ---CHECK

    Then we must ask why it occurs ----- CHECK

    Then we must research to learn why - CHECK

    Then we must ask how to stop it. ------ CHECK

    Then we must research our theorys how - CHECK (We are here.)

    Then we wil find out how.

    They've gotten us this far & U R bitching. erm Patience

  • @Achaeos6 lol youre a racist, your favorites are fucking racist hahaha, i wouldnt believe you man, first ill read some books about it

    not saying its impossible but i bet you dont know either, youre dumb enough to give a fuck about races

  • @FriedrichWilhelAhmet

    I was never a "Racist" until after alot of education I was faced with some inescapable conclusions on racial issues. I am now a White Nationalist because of education. Your belief that only "dumb" people can believe this way shows you are, not necessarily dumb, but at least ignorant, as in you have not learned better. Media and public school work hard to brainwash this belief into everyone. When you are ready perhaps you will look into it, become educated & understand.

  • @Achaeos6 It seems that you have at least a basic structure of logic.

    Do you think that the Nazis were all uneducated pricks?

    Its really simple to expose Nazis because the same money making system works now like then, maybe with another ideology, I know what Im talking about, Im German and my knowledge doesnt come from a *brainwashing* school system but from everyday people with no profit interest.

    Just ask yourself who could profit from people having a scapegoat. It makes people controlable.

  • Support Aubrey de Grey's research to defeat aging

    .

    Join 3w [dot] causes [dot] com/defeataging

  • aging is a huge burden on humanity. it's a curse that we are all born with. It will also be cured.

  • Agreed. Every read some of Heinlein's books like "The Cat Who Walks Through Walls", or "To Sail Beyond the Sunset". We really are coming up on a time when we will be rejuvenated every so many years.

  • Modern da Vinci.

  • I will not die for death will be dead when I am old to enough die---M.Osman

  • Aging is a barbaric phenomenon

  • @MSJ11 I agree. Aging is a hideous disease.

  • Imgine Wolverine with cancer...gross^^

  • He keep the beard because his wife likes it.

  • @Jogeta5 I hope (for him) his wife doesn't like glans' piercing

  • lol@the swedish accent

  • so does anyone whatever happend to this guy? any updates on his research or new vids?

  • am searching for vids... he might be planning a very big speech about ending aging.

  • @tonyhoffmans Don't know about Aubrey specifically, but the Methuselah Foundation is definitely still kicking around. Excited to see what the next wave of PR is whenever it arrives.

  • This is moving in the right direction! This man is working toward progress. The least we could do is support him.

  • @Shaunt1 you know this for sure?

  • @NewBaldwin It's what I believe. Who doesn't want more control over death?

  • we must cure aging.

    aging kills 100,000 a day. if you care about saving lives.

    target a way to stop ourselves from growing old!

  • we should cure aging yes...

    but he needs to talk a bit slower

  • Gerontology is a good place to start, then Ann Wigmore and a Veggan life style and juice fasting and throw in the Yoga and maybe martial arts classes..., raw foods and a smile :) There, you should be reversing the aging process all ready..., call me back in half a century...

  • Are you aging? Good... Good. )))

  • If you want him to succeed, why the foul language? I'm confused. You support these ideas, but act like a retard. Quit farting around, join our team goddamn it.

  • Wut?

    IMHO you're doing damage thinking you do good

  • Really?

  • take THIS advice:

    1. go fuck yourself

    2. repeat step 1

  • I doubt that any of you know any science at all. That is my criticiscm. It isn't smugness to say that things are much more difficult than pseudo scientists claim. Quite the reverse. That mangling of logic alone makes me realize how ridiculous your thinking is. Smugness is a symptom of thinking things are easy, just a matter of time, inevitably soluble. It is you who is smug, my friend. I am studying mathematics. I know how difficult it is to actually know something. You clearly don't. So sod off

  • The Foundation must accept the critics and criticism, debate is necessary, but the Foundation also must go on, with indefatigable determination. In fact, that's the spirit of Great Britain. And, if at first, you don't have success and you fall, just fall down and stand up again and again. And go on, go on, go on...with undefatigable determination. It is worth trying, what other way do we have? Resigning and doing nothing? Determination and perseverance. That's the spirit of Great Britain!

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  • I trully dislike your smugness about how everything is unknowable. Soon with in two years biotech univeristy in north carolina will be testing calorc resriction which will increase life spans by 50 to hundred years. Many things are knowable. Locking your self into the presumtion that we can not understand something, is the same as not trying at all. We will never know if its possible untill we try. I look forward to imortality if you dont want it fine.

  • A "cure" for ageing is inevitable. as long as humans are on the case, we wont stop untill we understand it. and what we understeand, we can control. i think what we need to study is cyborg ogans.. a computer in our body that can take over homeostasis if the set point varies too far. anyone ever think of engineering plant cell organelles into human cells? i think if i had chlorplasts and a UV source in an organ that could take over heart function in case of failure... it would be good. hmmmmmmmm

  • Yeah and like let's make big curly things that just lift us into generated vortices and transport us to anywhere in the world like the supermarket and the shoe shops and things.......oh yeah and let's make a big cake baking machine that only makes like reaaaaaaaaaaaaaally nice cakes and blancmonges too!!! Yeah then robo cop can fight with cycloborgK29Dalek and then we can take a chill pill made from recycled mouse enzymes. Yeah it's all so like, totally fucking nonesensicall BS zero brain nerds

  • @Stevekap8

    In all honesty, with under 20k views the viewers are more than likely mostly supporters of the movement and not random people who just happened to come across the video. Furthermore, those people will generally post positively. The same ideal is expressed in the fact that the video is over an hour long. That deters many people who are not greatly interested in the content.

    There WILL be money made and lost with this movement. That is, however, irrelevant.

  • I hope Google would help this technology to reach faster us!

  • Technology?  No son, technology is what you get when you put scientific descoveries into practice. At this point, its not even a scientific movent, more of a fund raising effort.

  • But it MUST succeed!

  • If people lived 200, reproduction would need to be limited..

  • Only people with 0 or 1 child will have the oportunity te get the therapy for free. That's what I think.

  • The longer and healthier lives people have, the lower the birth rate is. It's been happening for a century now.

  • i agree!!!!

    remember in the 1970s the average life span was like what less then 68 in the unitedstates?? people had babies at age 28 on average and had on average higher then 2 per family

    now its like 80 in the us as of 2009 and people have babies in the late 30s, and the average birth rate here i think is 1.7

  • It is important that more people become aware. I am compiling the best videos on youtube on future and technology in my channel's playlist "Our Future". Also google "Immortality Institute" and you will find a great community that works toward immortality, feel free to join and contribute your ideas and critiques.

  • the world will be like coruscant from star wars lol

  • "FACE IS THE INDEX OF THE MIND"

    We need to clear our subconscious mind to look young. Other techniques, suregeries, cosmetics are really waste of time and money.

    Type "liveinmatrix" in GOOGLE and follow the first link to learn the secret

  • Can our minds handle living forever ? Losing a loved one in an accidennt after living with them for a thousand years?. Would you become so desensitized that you could'nt have fun anymore ? Compare a 10 year old to a 60 year old, imagine 1000.

  • >Compare a 10 year old to a 60 year old

    Tithonus error.

  • $2.5 million worth of funding is up for grabs

    If you want to support Aubrey and one of his projects called "Undergrads fighting age related disease" then go to " membersproject. com/project/view/BVVE2C " (take out the gaps)

    You can vote for him there.

  • Aubrey de Grey proposes that if we manage to eliminate aging then the species will have to make a choice between eternal life or having children. If we lived forever without having children then the population would be static. At the moment, by having children, the population is increasing dramatically. Now, which one is more sustainable?

  • There are solutions to that problem:

    - By using stem cell grown meat animal husbandry will become a thing of the past, clearing up a lot of room for housing.

    - By building taller buildings.

    - By using less space per person for housing.

    - By starting to live underneath the Earth's surface.

    - By living on the ocean.

    - By living in the ocean.

    - By living on other planets.

    - By living in space.

    By the time we can reverse aging, several of these solutions will be possible.

  • How should we deal with hate? I don't think gene stop us from hating anything. By the way, should love prefer similarity in gene or differences in gene?

  • Not relevant to the question. But hey I'll answer you anyway. NO, we won't stop people disliking or hating things. I would suggest though, that people that live a long time will learn about themselves and other people and will realise what works and does not work in terms of social interaction and that they will be a lot more constuctive than short lived people.

  • Oh I see. And how exactly do you know at what point we will become capable of reversing aging?

  • I don't know that, but several of these solutions are already possible. We can build buildings over half a mile, using less living space is feasible and so are living underneath the Earth's surface and on the ocean. Stem cell meat is almost ready to hit the market. Our planet should at least be able to hold twice the amount of humans it does now, if we didn't have idiotic politicians. The technologies are already here.

  • ok let say i want to have a son. so i have to die to have a child. so the child will grow up without a father? just a question

  • IRONand..

    Can you expand on that argumnet. I don't understand what point you are making.

  • well Grey said to stop overpopulation either your immortal but if your gonna have a child then you need too stop taking the therapy that makes you immortal. does it mean the child will grow up without a parent?

  • I think what's more likely is that the child fills the berth of a dead non-parent.

  • i think every should live as long as they want...and i want to live forever

  • I´d say it depends on how old he/she is now and how fast the progress in this field (it´s a HUGE scientific field) will be...

  • i don't know...but you don't know either

  • im 75 will i survive g

  • if you cut off the germline stem cells from a fruit flies gonad. It's insulin signaling decreases, cuz of the CMD4 protein it produces. That slows aging %20-50%.

  • A nice theorist. The next step is to show us your mice that lived twice as long as normal mice. Science is not just saying "We went to the Moon, the next step is Alpha Centauri, in your lifetime!" It's doing it.

  • You are absolutely right.

    But I think we need people that can talk to the public, get more people involved with scientific research.

    Aubrey de Grey is doing a great job in this.

    I don't think he is a great biologist but he manage to get a lot of money for his cause.

    I hope, it will encourage great scientists to work on defeating aging.

  • I am a believer. Rock on Mr. de Gray.

  • 17:25 "Bad enough to be interesting"

    hoho what a maverick.

    Well go for it.

  • I think everyone should see the vid "How de Grey fooled everyone". He's a computer tech from Cambridge that used their websight to appear to be an on staff prof. Thats how this thing got going.

  • You are such a small minded, maladjusted fool. Even if what you say is true, any sane person would not give a fuck whether Aubrey de Grey appropriated the name of a university temporarily in order to achieve greater interest in his work. He has a vision of something magnificent and he is working intelligently to achieve it. What the fuck have you done lately for anyone you malicious little shit?

  • Ahh,,, there we have it. Name calling, the sign of true genious.

    "

    So, you admit de Grey appropriated (read "stole") the good name of this University, for a good reason. My you never be my lawyer.

    As it happens, I've done quite many good thinks for people lately, and not one of them involve mis-representing myself, or taking their money. Ciao

  • My apologies, Stevekap8. I was over the top. I just get angry when I see someone attack someone with a positive constructive vision based on fear or some other less than constructive emotion. AdG did not steal anything. He has a grand vision and is doing his best for that vision. In the grand scheme of things what you are accusing him of is pathetically trivial.

  • hes smart works hard he really does have a great brain.put your faith in science

  • I second the confusion at the empty seats... and only 2 questions... or really it was more like 1 question, and not even about the treatment but about something mentioned in passing.

    I wish I could go to these types of things, Aubrey is my hero.

  • It is excellent to find a lecture by the very intelligent Aubrey de Gray here. I find the idea of moving the mitochondrial genes into our more stable nucleus to be excellent. Having a backup for these proteins makes sense should we lose the ability to create them. While this happens on a cell-to-cell basis, their degredation is overall pretty uniform.

    However, having then produced directly in the mitochondria is more efficient I think, so we should find a way to repair a mitochondrion as well

  • this man and his scientific abilities, may I be allowed to say that this man is the funniest person I have ever seen.

  • Generally speaking, aging concerns women much more than men, yet it would be really surprising if all his knowledge and theories were coming from a woman.

  • 'Based in Cambridge UK' is deliberately misleading. He no longer has any affiliation with a university. They wouldnt bother saying this if the town wasn't famous for its university.

  • Actually, being in Cambridge is central to his career, which is based on being well-connected -- bringing together various fields, despite not himself being an employee of the uni.

  • Well that's a lie, but never let the truth stand in the way of a great conspiracy, right?

    >greater claims

    Name one.

  • *drops the mic and tips hat*

    PEACE!

  • last comment on this page,

    the trees live longer because they wear out their mitochondria much slower. So either animals who are very inactive or built very energy efficient tend to live longer. According to science and my bible, people before modern times would burn in the ten thosand calorie range every day with wat we consider crappy shit thrown togehter. life expectency in 1 hundred years of most mechanization 35 became 70-85

  • because mitochondria make energy, the most stress in the cell is there unless ur bombarded with beta particles or ionizing radiation. And if they have their own dna, it leads u to think, nature hasnt evolved a good enuff furnace heat shield when ur brains pressed up against the hot brick wall.

  • all im saying is that trees live for thosands of years on the same nuclear dna, that suggest nuclear dna is good for a very long time. However, mitochondrial dna actually is found to decompose predictably over time. As it get more distorted it can achieve efficiency rates as well as it used to. With only 6 protiens in a its dna any curruption may do nothing. When the mitochon. make less than wat is needed to fuel themselves, cell activity stops, death.

  • hey steve, did u say that when a cell splits into 2 daughter cells, that only 1 of them will age? Are u saying that 50% of all cellular life on earth is ageless?

  • I'm saying more than that, 100% of single cell life forms are ageless!! Think about it, if you define their age as spanning the reproduction process, than all single cell life forms are as old as life itsself! If there was a time span o that life,all of life would be dead!!!

    This isn't my theory. This is simple biology and simple logic.

    So, start with what you mean my "aging of cells". Think about what you are saying first. Then give it another go.

  • >if you define their age as spanning the reproduction process

    Nobody does. Senescence doesn't span the reproductive process.

    ~

  • Well, thats so nice, then, each time our cells reproduce, they start anew. Therefore, we never age. Well, done!

    Err, except we do age.. maybe this "we don't need to understand the cause" idea isn't the best...

  • I thought you meant the reproduction of the individual.

    There's the age of the cell(time-since-division), and then there's the degree of imperfection in the cell that distuinguishes it from a younger guy's cells. When the other bloke referred to "aging cells" he was no doubt referring to the damage that has been passed on from cell to cell during the lifespan of the organism.

  • I think this really gets at my point. Why would one type of cell age over th lifetime of the organism that it is a part of, and a single cell organism not age.

    I think the answer is the envirenment that the stomatic cell finds itself in. It is surounded by other cell, and infulenced by them. This we call development, when we like the result, and age, when we don't.

  • N.Sel. is the structuring force behind modern organisms. In later years of life, one is further from NS's zone of influence(the historical average moment of reproduction, age 19 or whatever). The historical influence of NS fades. So our structure fails. But the time-age of a single cell is not crucial here. The fact is, when a cell divides, the daughter cells get some of the physical imperfections of the parent cells(e.g. indigestible junk). And so there's a lifelong buildup of cell damage.

  • Or, maybe, just maybe, the age of a human has little to do with the age of the cell. That there are processes between the cell, that turn genes off and on in an extremely complicated cascade of event. Events which tend to benefit the young, perhaps at the expence of the old. For obvious Dawinian reasons.

    Yes, I'm certain I read that somewhere.

  • But this is another matter. SENS does not attempt to interfere with that aging process. To do so is called the "gerontology approach". The engineering approach is to get right in there and artificially restore the state youth, regardless of how aging initially happened. It's matter of tissue repair. Any gerontologist will tell you that the _difference itself_ between a young and old man exists at a cellular level. This in turn, impairs tissue function, which in turn leads to organ failure.

  • I see. And yet I'm certain that I read that the goal of this "movement" was to END the aging process.

  • No. The goal of his movement is to achieve rejuvenation, whilst allowing the ageing process to continue. If, at any point, he talks about "ending ageing", he is not referring to a true halt to the ageing process, but to periodical rejuvenation, that renders the ageing process negligible: Hence "Strategies for Engineered Negligible Senescence".

  • Also, inksterco, I'd like to point out again that your usual tactic, in the face of contrary opinion, is to ban an censor comments. It is important to get that out, as we are in a forum in which you are powerless to do so.

  • >usual tactic is to ban and censor comments

    Usual tactic, eh? Even though I've never done it, ever? Never. So, not a usual tactic.

    Your tactic, on the other hand, isn't even much of a tactic.

    You accused SENS of being a for-profit scam.

    This is demonstrably false

    You accused de Grey of having a fake PhD

    This is demonstrably false

    You said de Grey had no peer-reviewed work

    This couldnt be further from the truth.

    As always, I had to do your homework for you *after the accusation.

  • the cells execute a self inflicted mitosis(cellular suicide) in order to isolate the cells which contain nuclear DNA which has indeed reproduced to the point it may have lost too much original information.But if this is wat kills u,it surely does not age u, other wise cells in a environment of homeostasis and therefore evenly dispersed metabolic rates,of a certain type would all simultaneously fail.This would not involve a gradual continuous death over the period of ur life.

  • You say mitosis is cellular suicide!! Everyone else in biology seem to think its one cell dividing, becoming two. But you say its suicide!! Thats really wacky.

    If you want to learn about biology, you should read a book. Simply making this up isn't really the best way.

  • telemeters r on nuclear DNA not to end ur life, but to kill off a particular group of cells which may have reproduced many times more than say bone cells.If a certain group of say white marrow has produced more than the estimated amount of T-cells which should be made over the course of a lifetime(#of telemeters)in say only70%through their life so far,

  • holy shit stevekap8, u cannot be more ignorant to scientific fact unless ur were amish. guess wat, ALL EUKARIOTIC CELLS AGE. If u look at there biology they also have very predictable lifespans depending on their average life metabolic rate. ALL EUKARIOTIC CELLS die eventually of old age. Nuclear DNA will actually stay pristine for hundreds of years in a sterile environment(nucleus of a noninfected cell) before the essential radioactive carbons in the nuclear DNA decompose.

  • Oh really!! All Eukayrots die of old age? Even those that use mitoisis to reproduce? So, if one cell makes 2 daughter cells, which one of them "eventually dies of old age" as you say? If, for every reproduction, one of the two daughters is doomed to "die of oldage", what would you make out the growth rate to be? I'll give you a hint: zero!!!

    Sorry to intruduce math, logic, and science into this, please, do, get on with your praise feast.

  • You are kinding, right? You aren't saying that single cell species, that use mitosis (eukarats included)(one cell splits into 2), die of old age? How would that work then? Which of the two would die of old age? What would the growth rate be? Think!! you silly person.

  • The beard does attribute more of a mad scientist than the brilliant scholar De Grey actually is. I am a Biochem Major in college and have also read his book.  It makes for some great reading and his theories are quite legitimate.