Regulated Transcription

[xxTaKe2xx]

Biology exam on monday ,OMGOMGOMG

[roarlionsroar32]

too bad I'm failing my microbio exam tomorrow anyway

[ezoonjo]

Thank You! :D

[animaefreak]

They talk about regulated transcription, but not introns and exons? sigh...

Is the enhancer region the same at the TATA box?

[Casshyr]

@animaefreak TATA box is generally found in core promoter regions, and is responsible for recruiting general transcription factors. This is not same as enhancer regions, which generally are more upstream of the promoter, and can be couple of thousands of base pairs away. They recruit transcription factors that are not part of the core set for starting gene transcription, but instead regulate the level of transcription.

[allietacker]

Thanks for sharing THIS. Awesome Post!!

[ycxcjohn]

Enhancers are not necessarily upstream

[yellowmetalcyborg]

Thank you for posting all these videos, I enjoy watching them and they have proven very helpful in my biology class.

Thank you so much!

[TheKatKatPower]

thx for posting this video!! :-)

[melingom]

amazing stuff! great work

[jumanous]

wow. That is one complex set of machinery.

[chiaraviga]

great!

[jrg305]

So transcription factors determine which mRNAs are made when and how much, but what determines the presence of the transcription factors themselves? They have to have been transcribed too, which was caused by other factors that we don't know yet? I'm guessing other transcription factors determine the transcription of the transcription factors, etc.? It has to start somewhere...they really need to figure this out cuz bio is hard to learn since we don't know why they are there in the first plac

[Purpleminion]

@jrg305 hormones?

[jrg305]

@Purpleminion Yes, hormones certainly play a part in whether or not certain transcription factors are present (e.g. RXRs and RARs with vitamin A and D metabolism), but the missing thing in biochem is WHAT makes it all work like it works? Where is the stimulus for all this?! How do little proteins know where to travel or is it all concentration based and the impact of electronegativity is much larger at a subcellular level that it becomes nearly chemistry?

[Purpleminion]

@jrg305 the lack of or presence of certain proteins, and receptors in cells surely is what makes it work as it does, no? Proteins dont know WHERE to travel, they move depending on the difference in conc gradients, to low conc areas, and the certain receptors "pick" up these proteins and carry out the specific signal transduction pathways needed in the cell, i.e. the production of transcription factors.. its all strange and confussling stuff, one such thing kicks off another thing etc

[keebearfull]

thanks, ND State. Your stuff is always top shelf.

[mahbucket1]

incredible!

[professorM]

The machinery of biology is amazing.

[athlete117]

Thumbs up.

[rax2099]

very good

thx