The Complement System

[MsMdomin8]

I'm still learning all of this, but I think the classical system isn't used on a new ger/bug that the immune system just encountered. It can't see something for the first time & have antibodies ready to attack it. The second time it sees it it can do all of this. The complement has 3 different pathways it can take to kill things, and the classical one is the only one antibody dependent. Hope that helps.

[MikeyIV]

I thought that antibodies were from the adaptive system (plasma B cells). The complement system happens immediately (innate). How can antibodies already be on the bacterial cell? Wouldn't the adaptive response need to happen already? Please help me.

[eurovwgti]

C deez nutz.... That what I got.

[NIGHTMAREuki]

This my friends is called midfuckery

[imthetitsDD]

NO way this is true

[revilo314]

The C1q,r,s complex is poorly drawn. The serine proteases connect further from the globular head.

[moph9ai2]

CCCCCCCCCCCCCCCCCCCCCC, thats all i got

[banglaman91]

revisin for immunity - bradford pharmacy

[ptdlb18]

AGGGGHHHHHHHHHHHHH!!!!!!!!!!!!



[poisoncobra1]

What shit ! hey guys we 'd better play Call of duty rather than this fucking complex which will stop my mind ..

[SiegeX1]

This kills the cell

[agile52]

wow

[lidyaFACE]

1:41 -- ROCKET SHIP!

2:53 -- ROCKET SHIP LANDING!

that's all I got from this video..

[MJforever5690]

God I'm utterly confused but this was definitely better than the paper version.

[HaoSci]

NEAT! (I wonder where the names of the enzymes and proteins come from? It's seems some sort of numbering system...)

[MaySandersStokes]

@HaoSci the numbers were based on the order of which they were discovered :)

[katemariaoth]

this was very helpful! thanks!!

[AznTriad133]

What. The. Fuck.

Lost me at "Activation of the Complement System"

[TheTrumpBoy]

how do you know that ?

[dagmarie18]

I was reading my first aid for my immuno class and now i finally understand the complement system! Im so visual, so, thank u sooo much!

[miszkeem]

....uhm...WHAT?!!

[mguido6]

to wordy for me but i guess if it deals with something like this it must be impossible to put it in laymans terms

[edgening]

shoot! im trying to read my serology notes...still im having a hard time to understand this complement pathway....

[incudude311]

thank you so much!

[mate6007]

7 E.coli disliked this.

[mrindia1]

C3a cusses at C4 which then brings C5a, to ride on C3a's ass, the C5j rides on top of C8p, C9poop shits on C65386? Thus kills the bacterial cells! What...the...Fudge!

[tikok25]

this video saved me today:)

[NermenBastawy]

I like it !!!

[GuppyPal]

Immunology is one of the worst and most useless classes I've ever taken.

[sameric13]

@GuppyPal You, my friend, are an IDIOT.

How the hell is the way ur body defends itself "useless"???

[GuppyPal]

@sameric13 Maybe our experiences have been different. 1) I'm not going into the medical field. 2) We've been coming at things heavily from a molecular biology and biochemical perspective. Knowing the gene sequences of MHC molecules and the various biochemical pathways (intermediates and enzymes) of the various complement pathways is completely irrelevent to what I plan on studying. Knowing the biology of and physiological roles of NKC, lymphoid tissue, cytokines, etc, is useful, however.

[DJS6969]

For those who don't need to go into too much detail, the important parts are at 0:00-0:30, 1:43-2:13, 3:03-3:22.

[kaitpearful]

wtf? 

[drJOORI]

helpful video =)

[muugiilovett]

thanks for upload

[molecularmadness]

Say hello to my little C5bC6C7C8C9 complex bitches...

[greensky01]

This video is actually from the makers of microbiology textbook.

[BlueLittleBook]

Excellent explanation!!! So much better than the immunology text book. Thanks a lot!!!

[Boshkenobi]

C3-convertase nomenclature depend on country.

European = C4bC2b and American = C4bC2a if I am not mistaken



[Jawnfawn]

@Boshkenobi C4bC2a is the nomenclature they use here in Sweden, but they do teach in English so I'm not sure. It would be easier to memorize if its C4bC2b though.

[fosterj3435]

@Jawnfawn it's because the Cb complement was originally named "Ca"... most textbooks have switched the names of Ca and Cb to adhere to the nomenclature ( the "b" complements "bind" the membrane while the "a" complements go "away" from the membrane). I hope this helps.

[fosterj3435]

@Jawnfawn and in case you were wondering the "a" actually stands for anaphylatoxin (which is what they are)... the "away" abbreviation is just a mnemonic ;) 

[jacthemuss]

i love these videos thanks for creation/upload

[xqube]

THIS SHIT BE BLOWIN MY MIND

[TaintedxHalo]

@xqube lmaoooo

[coolhoney234]

there is a mistake. C4bC2b is the C3-convertase and not C4bC2a! The a-subunits act in most cases as cytokins. Am I right?

[dcute0989]

@coolhoney234 The a-subunits act in most cases as cytokines EXCEPT for C2a.. C2a is the larger moeity and it's one that binds to the membrane :)

[MrMckn]

AAAWESSSOOOOMEE



[aipippin]

thk god for this video

clear!

[nouraSa1]

may god bless who ever made this video .. thank you

[Plrosill]

Amazing video, clear explanations

[ceruleansky11]

beautiful :') thanks

[aamit10]

gr8..........

[thezohan2112]

LOL "c" this "c" that....im in trouble :P :S

[amel683]

this turns me on

[amnayousafnawaz]

soooo helpful. many thanks! :)

[thetruthistheonlyway]

omg

[katdaddimd]

Oh thank God for this! I don't have CD-rom drive (no money to buy one either)

[TheAlexacaius]

I know have a headache...

[drugbaron2007]

dude this is still confusing

[HopelessBrit]

What the fuck did I just watch???

[Archzenom]

@HopelessBrit This is the Complement System in Immunology.

[bots2moe]

You're the best man! thanks for sharing this with us! this is where youtube is actually helpful, rather than listening to the mommy and daddy in bed song! BRAVO!!! JUST SUPERB! THANKS!!!!

[erezsarel]

excellent video- good job!!

[erezsarel]

excellent video- good job!

[Wolff0Jakotey]

the classic pathway, excellent video!! regards from Mexico

[aviatik]

Excellent video. What is the strict definition of an anaphylotoxin?

[Vavzryn]

This video helped me understand this material much easier. Thanks for uploading it! I wish I could find videos like this for every topic I'm studying.

[Lewa500]

After seeing more and more of these types of videos, I am that more bewildered by the structure of the human system. It is amazing what nature can achieve, even in thousands of years ahead, I can only dare but dream for mankind to recreate even 1/100th of what nature has done.

[MedusaMrigesh]

After watching this 4 times in a row, the complement pathway finally makes sense to me :-)

[DanWilsonEngland]

Can someone please explain what the molecules such as C3a go of to do?

[joh02259]

@DanWilsonEngland

It becomes a chemotactic fragment and works as an anaphylatoxin that aids in the binding of mast cells to induce degranulation.

[DanWilsonEngland]

@joh02259

Ah right. thanks :)

[spatch8806]

thank god for youtube, i'd fail out of med school without it

[ironnica]

Sweet video. biology is horrendous lol. Thank you

[kawaietbelle]

thanku , very helpful, but complement system also uses the "Mannose binding lectin pathway" which is not mentioned , is there another video which explains the MBl pathway????

[suzanqusay7]

really thank you u made it easy for me

[metaltugo]

I have a question. what would be the join between classic and alternative path ways?? c5a??

[ThinKFasT03]

Yeah MAC you fuck that BACTERIUM UP!

[animeprincess21]

you lost me at bacteria

[dannyboy15]

Why don't you leave the labels up once you show them?!!! i keep having to pause to really take them in.

Look at khanacademy's videos- this makes it much easier!

thanks

[ironnica]

@dannyboy15 you should stick with them if you find that easier. this is brilliant for me

[Thekillerkat1990]

Great video... it really helped to clear my confusion.

[radhaharendra]

This is very nice and explain the all important points in a simple word......great video.

[dcurzake]

Great video. Made sense of a bunch of letters and numbers on my professor's powerpoint

[pakiboy1988]

watching this video made me hate immunology less

[ekaclem]

difficult to understand

[thesweetmolasses]

Holy Fuck my eyes just crossed =(

[Super240987]

wow this is so complicated im a new med student i dont understand it :(

[FliegenKlappen]

Is this for the classical pathway only?

[MeritCullen]

@FliegenKlappen yes, it seems so

[IMBLUESTREAK23]

My professor played this to the class as his intro to complement. Needless to say, there was much laughter. FML :(

[Canigoripelushtappo]

Can you repost this video with english subtitles? I'm an italian student of medicine; i understand english, but only written one. With the spoken english i have some difficulties. (excuse for my terrible writing :( )

However, good video!

[andreeabara]

Hy!

I am student in a small country from Europe. Firstly, I want to thank you for the quality of your work. My question is if I can make subtitles of your video in my language (roumanian) and re-post them on you-tube, specifing the source. Or, if you agree, I can send you the subtitles so you can attach them on your you-tube channel.

I wait for an answer from you at the comments.

Thank you!

Respectfully,

Andreea Bara

[Abraley42]

Just had an hour lecture with a professor with a bad accent trying to explain this, 3 minutes on youtube, crystal clear...

[Ercel09]

im glad im in mathematics holy ... this is confusing

[pdxmomazon]

blarg...

[abeness88]

love this!

[Stepes]

How the hell am I supposed to remember all this ****?

[AB7522]

THUMBS UP IF YOU THINK MED SCHOOL WAS A MISTAKE...



[Tyrael02]

@AB7522 give up your spot for those of us who want it, then.

[sicksingh]

immunobiology is hella gay

[rockernepali]

cant get anything but ur doing good job

[xforestberryx]

this is the classical pathway?

[Acetaminophem]

It has an effect like suddenly ligthing a torch in a middle of a dark cave...

Thanks for posting :)

[sifisto]

simply outstanding, I understand now the nightmare I was trying sort out. You made sense of it,and more so made it fun to understand.

[big1buddy]

Where was I when not watching this video 2 weeks ago?

[Hatsworth101]

I thought you were gonna talk apout complementing PEOPLE!

[martinoestergaard88]

@Hatsworth101 HAHA lol

[jahrleriksen]

Simple and clear, thanks!

[buurbarkade2009]

Conclusion: activation of complement system results when the C1  components of the complement system binds to the Fc region of one IgM antibody molecule.

[hertsplays1]

UH pharm ___>

[Oxygaunt]

I 11pm now and I need to learn this for 9am tomorrow morning.. yeah.. I'm fucked -_-

[OldgoatInABlackcoat]

same here :P

[dennischan88]

This video save my day!

[ralaverdec]

thx!!

great video XD!!

[prashanth1405]

thank you! great revision for my exam. our prof actually played it in our lecture hall!

[TheOriginalEmmalemma]

@prashanth1405

same here! Our lecturer ONLY uses Janeway's Immunobiology although he's still only using the 6th ed lol

[Serkant75]

this is faster learning than just to read it over an hour from a text book

[hani99ms]

thanx, i have an immunology exam tomorrow, and it really helped

[archery75689]

very cool, great video

[crazymann]

mmm its just the classic pathway, there´s a video with the lectin or the alternative pathway around there???

[gulz11]

this video is so helpful, i actually understand complement now :)

[StarsKMandamaz]

yes this is the classical way :)

[ionsmobile]

Thank you this is very clear now.

[constipatedart]

Thank you. It's so much more intuitive to think of complex processes like this and clotting with animations instead of flow charts.

[jigrajattida]

this is the classical pathway right?

[BlueDevilBAMF]

Yes, it's the classical pathway... the Lectin pathway starts with MBL and MASP1/MASP2, whereas the alternative pathway signals through the serine proteases Factor B (analogous to C2 in the classical pathway) and Factor D. All converge on C3 and then C5

[StarsKMandamaz]

You know where i can find a video of the Lectin pathway? i found the Properdin Way, it was clear, like this video.

[imsangfroid]

Very good video and excellent explanation.

But it would have been nice if the names (c3, c4 etc ) were written on the molecules instead of just disappearing in a flash.

Excellent video nevertheless.

[whiteglovedoc]

very detailed...

[mirfarhangf]

you have made it very difficult.

[herannatomy]

this would be of great help for my microbiology test tom ;) thanks!

[afhdfh]

Nice vid! It makes me once more realize how uncreative we Biologists are with names though. :D

[laila1058]

The video is good for easy understanding but ,

IT HAS A MISTAKE:

1:10/3:21 the small peptide released after c2 proenzime is cleaved by c1s, is c2a (not c2b). c2b attach to c4b to form c4bc2b or c3 convertase.

[garlandscience]

laila1058,

The nomenclature in this video is the original designation of the components and is the most widely used.

The nomenclature that you suggest was used by previous editions of the text that this video is from, Janeway's Immunobiology, but we have changed it for current and future editions to be more in line with the mainstream of complement literature.

Thank you for your comment.

Best,

Garland Science

[ESsmich]

I also tripped up on the C4bC2 (a/b) term.

In my book (Grundwissen Immunologie (German Edition)) is also the tern C4bC2b used.

I was convinced that smaler komplements are termed "a" , so C4bC2b would be correct.

Why is it changed now in the mainstream of complement literature?

[andympeers1]

@garlandscience i've heard both pathways are acceptable, great video all the same

[efollet5]

@laila1058 : im afraid u r wrong..c3 convertase is c4b2a and not c4c2b.

the smaller peptide in c2 is c2b and not c2z. this is an exception .

[Domjuan626]

@laila1058 - Exactly, it is c2a that stays with the complex...there were some nomenclature issues awhile ago, and the science world generally stick with the original name of something, even if it doesn't exactly make sense, or is not consistent.

[Sn0wb0ard123]

@laila1058 1:10 is actually correct ... whats left is C4B2a.

[russe050]

@laila1058 The video is correct. c2a is actually what binds to c4b to form c3 convertase, not c2b.

[dapukejuice]

@laila1058 Depends on who you talk to... the nomenclature has switched back and forth for the C2a and C2b.

[First011]

how cool!

[brunostafe]

excelent explanation, thank you very much

[gabrielzaum87]

Well done... ^^

[karafacia68]

very good video. explains in detail.

[gtobr]

This is the best video and also the best class I saw in youtube.....

Very good!!!!

[Alcidesnt]

OMG!!!!! Amazing!!!! =D

Congratulations Garland Science ... The best scientific channel of the Internet!