Video 2. Spreading depression and migraine

[rkraig]

Interesting perspective and thought! I think you idea fits the functional changes that occur with increased excitability and spreading depression though deciphering a functional utility for the "adaptive" resposne requires some thoguht. As a first conclusion, I'd have to say it seems like it would be a "maladaptive" response.

[radionlibrarian]

Could spreading depression be understood as an adaptive response to counteract the escalating electrical activity that immediately precedes it? i.e., is it a sort of built-in fail-safe?