a bit blanketed. The paradigm has shifted from the Arg16Arg homozygous phenotype being the GOOD one in the 90s, to showing it being the BAD 1 in more current literature. The controversy is far from resolved, and no real clinical extrapolation may be made from any of the clinical or in vitro data yet. Even so, looking at 1 SNP is inappropriate to even looking at all the SNPs in 1 gene versus an entire system of genes encoding for many proteins/receptors/enzymes in just the ASM relaxation pathway.
a bit blanketed. The paradigm has shifted from the Arg16Arg homozygous phenotype being the GOOD one in the 90s, to showing it being the BAD 1 in more current literature. The controversy is far from resolved, and no real clinical extrapolation may be made from any of the clinical or in vitro data yet. Even so, looking at 1 SNP is inappropriate to even looking at all the SNPs in 1 gene versus an entire system of genes encoding for many proteins/receptors/enzymes in just the ASM relaxation pathway.
piceras 4 years ago
great
perfectcyclenet 4 years ago