Complement Cascade LOL

[naseerahvj]

LMAO!!!! That is the best discription ever! I'm a Medicaal lab student and when I first got my clinical books I went from, "this is soo cool" to "OMG I have 2 years to memorize all this before my cirtification exam!"

[tishwalter]

I lolled at the description. So glad I only need to know the vague way this works.

[CitaL0v3]

We had a similar video in microbiology... same thing happened... nervous laughter, obnoxious laughter, nervous laughter and silence. lol too funny

[ShogunPJ]

We were shown this in our lectures to, same response from the UK hah

[sautjansurarrusinur]

Hahaha!

[cat1edinburgh]

Ooh I just saw this in a lecture today :) Need something to help..!

[BlitzHeavyMetal]

It's been a year since Immunology and I still love the complement cascade.. And then they teach it again as a seminar for us medtech seniors. And i forgot everything again..

[avista100]

OMG at first i thought you were from my class, but you r from the us and I'm from the UK..... THIS VIDEO WAS PLAYED TO OUR YEAR GROUP ASWELL.... AND WE DID THE EXACT SAME THING... EXCEPT ALL ~300 OF US STARTED LAUGHING DURING THE VIDEO WHEN IT STARTED SOUNDING RIDICULOUS ... lol the lecturer laughed and then told us to pay attention and played it again. LOL

[chungmaster2332]

This was my favorite video from Immunology class. When I first saw it, I was baffled by it. But now everything makes sense.

[fury17deco]

I am taking an Immunology and Serology exam on complement this morning as part of an MLT program. For some reason, I haven't had as much trouble understanding complement as my fellow students. This was a good graphical representation of the classic pathway. Do you also have video of the alternate and manose binding lectic pathways?

[robertspringthorpe]

Thank you, thank you, thank you for this! Definitely the best vid I've seen which describes what I consider to be one of the hardest concepts to grasp in medical science.

Anyone know where the original video can be found??

[markzanewick]

thanks for uploading this, this is by far the best video on youtube about complement pathway even though its a video of a video lol.

[DJS6969]

We had this is our parasitology lecture... and the same reaction; silence, laughter, louder laughter, silence... I still have no idea what the hell its on about, if you still have this video could you plz E-Mail it to me or link me 2 a d/load site? cheers

[doctorsartorius]

thanks for the upload!

[Cindyrelisha]

not bad

[EmmVeePeePBN]

Haha, we had a similar video in my immunology class, with the exact same reaction.

PennState with Dr. Mastro by any chance?

[CitrusCat]

I'm afraid not, this was at the University of Colorado in Boulder with Dr. Fleshner. But I think that the videos in that Immunobiology text have a sort of universal effect on college students nationwide. :)

Did you take immunology recently? I took it last spring semester and watching this now, it's amazing how much of that class never made it past my hippocampus. Good thing I kept the book + CD to review before I apply to any grad schools.

[KulaAShaker]

This is very important. Each C1 molecule needs two of its globular heads to be bound (an antibody each) for it to be actiivated. If there is only one C1q molecule (therefore one globular head) how can the C1 molecule be activated and thus continue the cascade?

[CitrusCat]

Sorry to inform you that I am by no means an expert in immunology, merely an undergrad that was amused by the "intensity" of this video. I'm sure that if you spotted a mistake it could very well be there, but panicking on my comments won't get you anywhere. :P Try talking to a professor instead.

[KulaAShaker]

am doing immunology now..we did not even have a video..just a warning that this may be complicated lol...anyway im right, according to my textbook anyway, the video is wrong.

[KulaAShaker]

The beginning of the video may be wrong.

In my textbook (written by Peter Wood), it says the C1 molecule consists of 6 molecules of C1q. The video says there is only one. Its quite clear from the image itself that there are six. Count those heads at the bottom (their proper name is: globular heads) of the C1 molecule. There are six; each head belonging to one C1q molecule.

[pecatum1]

2 cbo1412

In former classification, C2a and C4b components generate C3 convertase. Nowadays, we call all components that attach to the membrane with "b" letter, and "a"-components acts as anaphylotoxins (mostly C3a and C5a).

[AlphaSierra5]

So, for the record, classical C3 convertase C4b2b

[viki28mb]

cool video man.. Its makes me easier 2 understand.....

[JediFalco]

HAHAHHAAHAHAHAHAAAAAAAAAAAAAAA­AAAAAAAAAAAAAAAAAAAAAAAHHAHAHA­HAHHAHAHAHAHHHAHAHAAAAAA OCTOPUS! I hate immunology. And complement. And C3. THe C stands for CUNT.

[sumo7274]

i find it hard to understanding immunology :(

[EvelcyclopS]

c4b and c2a form the c3 convertase c4b2a...

[cbo1412]

I had this Immunology class today and as I was reading the textbook and watching this video, I think that the video may have a mistake: the C3 convertase isn't actually the grouping of C4b and C2b? Because the woman in the video says that it is from C4b and C2a... And also, the C2a is actually the anafilatoxin that is relised from the activation of C2... Either is that or the Robbins' Pathology is wrong...

[ppbto90]

you r totally right buddy, but this video still very cool.