Cancer Immunotherapy - Virotherapy : Antibody HuLuc 63 - Immune response to cancer cells

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NOTE:

(Immunotherapy Research)

Dr. Cassian Yee, Drs. Zihai Li and Bei Liu,, Zheng Cui, Ph.D, William Coley, Victor Ambros, Gary Ruvkun, and David Baulcombee

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Video explaining the way in which the antibody, HuLuc 63, appears to induce anti-tumor effects by binding to a protein that is only expressed on the surface of myeloma cells.

This initiates antibody-dependent cellular cytotoxicity activity that kills myeloma cells and leaves healthy cells intact.

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Coley developed the theory that it was the infections which had helped patients in the past to recover from their cancer.

So he began to treat patients by injecting a brew of Streptococcus pyogenes directly into inoperable tumors.

The treatment was most effective when it provoked a fever and a full-blown infection.

According to Stephen Hoption Cann of the University of British Columbia, "He had successes you simply couldn't hope for today, curing even extensive metastatic disease."

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(RobertsReview, RI, USA) -- Immune cells in some cancer patient recognize, attack, and kill cancer cells, leading to full patient recovery.

Recently Steven Rosenberg at the National Cancer Institute isolated these cancer kiling T cells (tumor-infiltrating lymphocytes) in a patient who had successfully beaten melanoma.

He then introduced genetic information from them via a harmless retrovirus into the T cells of patients suffering from active cases of potentially deadly melanoma.

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Video explaining the way in which the antibody, HuLuc 63, appears to induce anti-tumor effects by binding to a protein that is only expressed on the surface of myeloma cells.

This initiates antibody-dependent cellular cytotoxicity activity that kills myeloma cells and leaves healthy cells intact

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Platelets and leukocytes carry a surplus of fixed electronegative surface charges.

Thus a spontaneously occurring positive polarity in injured tissue results in accumulation of platelets and then thrombosis of capillaries surrounding a site of injury.

his mechanism can also account for attraction of leukocytes to a site of positive electrical potential in injured or diseased tissue.

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"By using a probe to shine a light on the tumour, the antibodies at the right place in the body can be brought to life. Any antibodies in the rest of the body will remain dormant, meaning side effects can be minimised.

The activated antibodies then cause immune cells in the blood called T-cells to attack the cancer."

"Just a few minutes of the light therapy directed at the region of the tumour would activate the T-cells causing her body's own immune cells to attack the tumour."