Lady Gaga performs Yoü & I as Jo Calderone with Brian May during the MTV VMAs!

[MrFuropi]

The best guitarrist Brian I love you. THE RED SPECIAL, YEAH

[gseixas97]

Brian is the BEST GUITARRIST

[royraaijmakers]

I was never a Gaga fan, but this one is far more than awsome!

[OhLittleRamona]

I was never jealous of gaga until this⋯⋯

[jueriyock]

Gaga and Brian are the great artists!

[Angeee017]

I don´t know if i have the right to miss the old (young) Brian May, because i was born in 1993, but i do.

[TheAshwathiPillai]

@Angeee017 We all do :) But time changes everything. All we can have is those nostalgic memories! :)

[heathercferris]

Love the confused and slightly horrified looks in the audience. Tap into your inner minority hormone sometime peeps! Men and women both have testosterone AND estrogen. Try letting the other side out for a spin. You might just feel liberated and a little less afraid. : ) The greatest artists don't keep you in your comfort zone! Way to kick it up a notch Gaga!

[ShamanicRocker]

@heathercferris So,so,so true.

[maurawolf99]

When I told my mom about this, she finally figured out that Brian May is not dead.

[lisatunner]

SHIT. Wtf brian had in head to play for this creature came from hell???????????????

[keefization]

brian may wants lady gaga to sing for queen i hope she does it i think she would be good

[caussin1]

@keefization Sorry, but Queen has said in a recent interview that Gaga with Queen will never happen. They were emphatic.

[SteweeGriffin86]

brian may is the best.....great performance

[nicofeder]

@SteweeGriffin86 right i dont like lady gaga but on her music taste its nothing wrong rate whence gaga come from