Radiation not lymphopenia causing graft verus host disease and tumor rejection

[stemcellpatents]

another interesting video. We will likely post this on our website.

see this Prog Clin Biol Res. 1988;272:351-9.Links

Observations on the role of endotoxin in graft-versus-host disease.Lampert IA, Moore RH, Huby R, Cohen J.

Dept of Pathology, Hammersmith Hospital, Royal Postgraduate Medical School, London.

[stemcellpatents]

We have used a conventional murine model of bone marrow transplantation (BMT) to make a detailed study of the histological features of graft-versus-host disease (GvHD), and to study the effects of oral antibiotic decontamination of the gut flora. Comparison of the histological appearances of the small and large bowel indicated that the features of the GvHD were more severe in the large bowel. Bowel sterilisation caused a striking reduction in the severity of GvHD, both in the gut and at a

[stemcellpatents]

distant site (the skin of the ear). The different effects of GvHD in the large as compared to the small bowel suggested that a factor was operative locally, and the effect of sterilisation linked this to the bacteria in the bowel. The fact that sites remote from the bowel were also affected suggested that a diffusible factor from the bowel produced by the bacteria of the gut was responsible. Studies elsewhere have suggested that the factor involved is likely to be endotoxin.

[stemcellpatents]

In these experiments however it was evident that systemic administration of endotoxin did not aggravate the disease process and that in some instances the reverse was obtained. If therefore endotoxin is important the dose and its mode of its administration are likely to be critical.

[taniawatts]

this is an interesting paper that supports what the video is saying from the perspective that microflora is important. However this abstract states that endotoxin is not the culprit. Maybe there was a different dosing regimen that was used? in any case clinically i know that there is some degree of prophylactic antibiotic that is used before bone marrow or cord blood transplants. The question would be whether the regimen can be improved upon.

[floricabatu]

wow this is very deep science

if cells are put into a person who has an immune system already then why do you need to take aobut strage explanations when really what is going on since what is happening is that the cells introduced are more than likely cleared by the person recieving them.

when you put the cells into patients that already dont have a immune system they cause this disease since the administered cells have a chance to multiple and get activated

has nothing to do with

[cellmedicine]

the mice in the study did not have an immune system but yet the radiation therapy made the immune system much more active, as evidenced by regression of established tumor AND induction of vitiligo.

Since the mice had no immune system but still had an immune activation after the radiotherapy, it seems that the radiotherapy is associated with this hyper stimulation.

if you go on pubmed and search the words "homeostatic expansion" you may see a lot more info

thanks for the comments!!

[skatergirl333]

very interesting immunology description. Many years ago William Coley used backteria to induce anticancer immune responses. maybe those bacteria were causing a similar effect as the one that you are describing here that is caused by permeabilization of the colon as a response to radiation

maybe people should eat yogurt before transplantation so that the colon will not have so much toxin and therefore they may not have this hyperactivation

but maybe this hyperactivation is needed ?