so basically someone with Klinefelters is no different than anyone else except they have an extra X. Because even people with XX or XY can have learning disabilities...
@Aleksei5055 Some geneticists call XXY a syndrome, but 'syndrome' means "a collection of symptoms indicative of disease." So those geneticists are mistaken. Chromosomes that are usual are not indicative of disease, and 1 of something cannot be called a 'collection.' Klinefelter's syndrome is a collection of symptoms, such as female pattern pubic hair, fat distribution, sparse facial & body hair, low testosterone. BTW All males when they start puberty have female pattern pubic hair, the clue.
@Aleksei5055 This the way it works, XXY CAN have none of or all of the conditions mentioned in this video. It depends on many other factors as to what their difficulties will be for each individual. The ONLY universal fact affecting all XXY's is that they are XXY. Looking at just 1 disease they can get, the disease they're all assumed to have, Klinefelter's syndrome, the ONLY universal characteristic is small firm testes. Osteoporosis only comes about in the UNTREATED KS men.
@Aleksei5055 The condition Klinefelter's syndrome isn't really as disease at all. It is the symptoms of a disease, and that disease is called Seminiferous Tubule Dysgenesis.The seminiferous tubules are the structures in the testes where sperm develop. As they are defectively formed, that's what 'dysgenesis' means, the testes are small and firm. If an XXY man does not have small firm testes he does not have Klinefelter's syndrome. KS and XXY are not synonymous. This video fails to note that fact.
I liked your video except for one thing. You should have interviewed someone with the diagnoses. I would have been more than happy to help you. As I do have it, I keep myself up to date on everything. And most things are true in your video. There are complications of this disease I could write a whole book about and the doctors who don't understand it. Those studies that ChromosomesXXY seen aren't all true. BTW my IQ is 128, which is probably lower than my Siblings.
@ajt1012 If time is of any relevance, I was diagnosed at 16.5 and treated since 17 for Klinefelter's syndrome. I have now been taking testosterone for 35 years. Zdunmar has described his circumstances. That they are not the same as mine can hardly be descried as unusual, after all he did go for 32 years without a diagnosis, whereas I went for half that time. He developed osteoporosis at a very young age because he was not treated. Testosterone is not designed to improve fertility. (next)
@ajt1012 Testosterone will in fact reduce fertility as sperms need to be saturated in testosterone to develop properly. Men with KS have defective testes to start with. Testes only get as big as they do in men without KS because of testosterone production.Men with KS have testes that can't expand from increased instructions to produce testosterone as their seminiferous tubules retard the growth of their leydig cells, the cells that produce testosterone. We take TRT to replace what we don't make.
@zdunmar I must check your channel out for updated information that you make available, or you make sure you're kept up to date, I make sure as many people as possible are kept up to date, and I'm ChromosomesXXY. The matters I report on from statistical analysis are all true, but if you can come up with anything that is untrue in my videos or text statements that are untrue, and you have the evidence to show they're untrue, I'll be more than happy to delete the videos and amend my statements.
I don't know how true those studies are. I have XXY KS and wasn't diagnosed until I was 32. Before taking Testosterone I had Osteoporosis (-2.5BMD) and no sperm. With TRT I have great ejaculations, yet no swimmers. My BMD has improved to -0.9 BMD in 6 years time which put me in at Osteopenia. I had no facial hair and a pear shaped physique, like a girl. The only body hair I had was above my genitals. I have secondary male characteristics. Improvements are good with TRT but remain sterile.
@zdunmar Of the fertility study I am referring to 50% of the XXY participants had some sperms in their ejaculate. Obviously then 50% had no sperms and I have never had any sperm production at all in my ejaculate. However, you must be aware of ICSI, when even immature sperms a can be extracted form XXY's testes and used in IVF? This is excellent news. When candidates are selected for ICSI they have to stop TRT as exogenous testosterone prevents the formation of sperm.
Recent studies indicate XXY boys in early puberty may be fertile. XXY men with KS have fathered their own children. All the medical ailments you mention can be prevented with testosterone. Other medications are used to treat learning problems that have nothing to do with KS and everything to do with the additional X or X's & Y's. Being XXY is not all doom and gloom. :)
@ajt1012 I used to own ChromosomesXXY but it got 2 red flags in quick succession and I closed it down. But anyway, as time has gone by I have learned a great deal more accurate information. The LD's we CAN get are associated wit the additional X material, not KS, which is in fact just a collection of symptoms of the disease seminiferous tubule dysgenesis. And we have no more complete X's active in our cells than any other person, just 1. Look up X inactivation for more information.
Ok, for your next project, the karyotypes known to bring about Klinefelter syndrome are XXY, XXYY, XXXY XXXXY & XY/XXY mosaic plus any number of other mosaic combinations. It's the most common sex chromosome abnormality, I doubt it's the most common sex disorder. The correct incidence rate statement of the chromosomal abnormality for XXY is "between 1:500 to 1:1000 live male births." How many men have Klinefelter's syndrome is unknown, most are never diagnosed. Infertility is not guaranteed.
great comments people
great information shared
well done to all the posters
peaceandparty 9 months ago
so basically someone with Klinefelters is no different than anyone else except they have an extra X. Because even people with XX or XY can have learning disabilities...
Aleksei5055 10 months ago
@Aleksei5055
Of course.
ajt1012 10 months ago
@ajt1012 then why the hell is it called a syndrome... why can't they just be someone with an extra x
Aleksei5055 10 months ago
@Aleksei5055
Because having an extra X may come with some extra.. complications, as mentioned in the video.
ajt1012 10 months ago
@ajt1012 point made... thanks for the video btw... i had no idea bout this until I came across it on YT
Aleksei5055 10 months ago
@Aleksei5055 No problem!
ajt1012 10 months ago
@Aleksei5055 Some geneticists call XXY a syndrome, but 'syndrome' means "a collection of symptoms indicative of disease." So those geneticists are mistaken. Chromosomes that are usual are not indicative of disease, and 1 of something cannot be called a 'collection.' Klinefelter's syndrome is a collection of symptoms, such as female pattern pubic hair, fat distribution, sparse facial & body hair, low testosterone. BTW All males when they start puberty have female pattern pubic hair, the clue.
XXYforLIFE 9 months ago
@Aleksei5055 This the way it works, XXY CAN have none of or all of the conditions mentioned in this video. It depends on many other factors as to what their difficulties will be for each individual. The ONLY universal fact affecting all XXY's is that they are XXY. Looking at just 1 disease they can get, the disease they're all assumed to have, Klinefelter's syndrome, the ONLY universal characteristic is small firm testes. Osteoporosis only comes about in the UNTREATED KS men.
XXYforLIFE 9 months ago
@Aleksei5055 The condition Klinefelter's syndrome isn't really as disease at all. It is the symptoms of a disease, and that disease is called Seminiferous Tubule Dysgenesis.The seminiferous tubules are the structures in the testes where sperm develop. As they are defectively formed, that's what 'dysgenesis' means, the testes are small and firm. If an XXY man does not have small firm testes he does not have Klinefelter's syndrome. KS and XXY are not synonymous. This video fails to note that fact.
XXYforLIFE 9 months ago
I liked your video except for one thing. You should have interviewed someone with the diagnoses. I would have been more than happy to help you. As I do have it, I keep myself up to date on everything. And most things are true in your video. There are complications of this disease I could write a whole book about and the doctors who don't understand it. Those studies that ChromosomesXXY seen aren't all true. BTW my IQ is 128, which is probably lower than my Siblings.
zdunmar 1 year ago
@zdunmar
Although I may not make another video, I would very much like to know more about Klinefelter's , if it doesn't take away too much time.
ajt1012 1 year ago
@ajt1012 If time is of any relevance, I was diagnosed at 16.5 and treated since 17 for Klinefelter's syndrome. I have now been taking testosterone for 35 years. Zdunmar has described his circumstances. That they are not the same as mine can hardly be descried as unusual, after all he did go for 32 years without a diagnosis, whereas I went for half that time. He developed osteoporosis at a very young age because he was not treated. Testosterone is not designed to improve fertility. (next)
XXYforLIFE 9 months ago
@ajt1012 Testosterone will in fact reduce fertility as sperms need to be saturated in testosterone to develop properly. Men with KS have defective testes to start with. Testes only get as big as they do in men without KS because of testosterone production.Men with KS have testes that can't expand from increased instructions to produce testosterone as their seminiferous tubules retard the growth of their leydig cells, the cells that produce testosterone. We take TRT to replace what we don't make.
XXYforLIFE 9 months ago
@zdunmar I must check your channel out for updated information that you make available, or you make sure you're kept up to date, I make sure as many people as possible are kept up to date, and I'm ChromosomesXXY. The matters I report on from statistical analysis are all true, but if you can come up with anything that is untrue in my videos or text statements that are untrue, and you have the evidence to show they're untrue, I'll be more than happy to delete the videos and amend my statements.
XXYforLIFE 9 months ago
I don't know how true those studies are. I have XXY KS and wasn't diagnosed until I was 32. Before taking Testosterone I had Osteoporosis (-2.5BMD) and no sperm. With TRT I have great ejaculations, yet no swimmers. My BMD has improved to -0.9 BMD in 6 years time which put me in at Osteopenia. I had no facial hair and a pear shaped physique, like a girl. The only body hair I had was above my genitals. I have secondary male characteristics. Improvements are good with TRT but remain sterile.
zdunmar 1 year ago
@zdunmar Of the fertility study I am referring to 50% of the XXY participants had some sperms in their ejaculate. Obviously then 50% had no sperms and I have never had any sperm production at all in my ejaculate. However, you must be aware of ICSI, when even immature sperms a can be extracted form XXY's testes and used in IVF? This is excellent news. When candidates are selected for ICSI they have to stop TRT as exogenous testosterone prevents the formation of sperm.
XXYforLIFE 9 months ago
Recent studies indicate XXY boys in early puberty may be fertile. XXY men with KS have fathered their own children. All the medical ailments you mention can be prevented with testosterone. Other medications are used to treat learning problems that have nothing to do with KS and everything to do with the additional X or X's & Y's. Being XXY is not all doom and gloom. :)
ChromosomesXXY 1 year ago
@ChromosomesXXY
Thank you for your input, as though I did make this video, I still know little about the syndrome. Thank you~
ajt1012 1 year ago
@ajt1012 I used to own ChromosomesXXY but it got 2 red flags in quick succession and I closed it down. But anyway, as time has gone by I have learned a great deal more accurate information. The LD's we CAN get are associated wit the additional X material, not KS, which is in fact just a collection of symptoms of the disease seminiferous tubule dysgenesis. And we have no more complete X's active in our cells than any other person, just 1. Look up X inactivation for more information.
XXYforLIFE 9 months ago
@XXYforLIFE
That's pretty interesting!
ajt1012 9 months ago
Ok, for your next project, the karyotypes known to bring about Klinefelter syndrome are XXY, XXYY, XXXY XXXXY & XY/XXY mosaic plus any number of other mosaic combinations. It's the most common sex chromosome abnormality, I doubt it's the most common sex disorder. The correct incidence rate statement of the chromosomal abnormality for XXY is "between 1:500 to 1:1000 live male births." How many men have Klinefelter's syndrome is unknown, most are never diagnosed. Infertility is not guaranteed.
ChromosomesXXY 1 year ago