intramembranous ossification

[superman13fu]

Jk!

[superman13fu]

Is this the bear from the Cleveland Show.

[kris1755]

thank you for the video, it is very helpful!

[Tadelra]

love it! fav + like + I'm sharing this with my family!

[Tinocanales]

Its 1:40 am  and trying to figure out this process by reading the material from my notes. This presentation made me understand the process. thanks a lot. !!!!

[lonly4uonly]

thanks for but may you please do another upload regarding the development of

osteoblast from mesenchymal cell showing various signalling molecules like bmp

wnt sclerostin and others ... it is a very tough topic to grasp ....

[Th3SweetP3as]

okay this totally just saved me for a test tomorrow, i totally get it now, thanks soo much!

[aimezmoi13]

Nicely done! Are you a Doctor?

[hpdutra]

@aimezmoi13 does phd count as doctor these days?

[missjoanbonzo]

thank you for posting this video!!! Makes alot of sense!

[enjoitheworld416]

Dude you sound exactly like Fozzy Bear.

[missjoanbonzo]

@enjoitheworld416 Omg like Yoga Bear huh!?! lol

[enjoitheworld416]

@missjoanbonzo No you have your bears mixed up. It's an honest mistake. Just type Fozzy bear into that search bar up there ^ you wont regret it :)

[hpdutra]

@enjoitheworld416 Actually, I look Fozzy Bear too. Is he Brazilian?

[skinnyguinea1234]

who knew seseme street monsters care about bone growth.

[bluealfie]

Very helpful, thank you.

[Nick153452]

You make me feel dumb :-/

[hpdutra]

@Nick153452 Don't feel that way. I did not learn that without much studying. So in that sense I am very dumb. I hard working dumb :)

[mycrickethighlights2]

thanks

[dentalstudent30]

Dear hpdutra,

A fantastic video. I learned so much and the list is brilliant with your drawings. Please keep posting. And like the previous poster, endochondral ossification would be very very useful. Thanks very much

[yarrahgoffincher]

Hi, I heard that intramembranous ossification also involved structures called 'spicules'. What are they and what do they look like?

[hpdutra]

@yarrahgoffincher I added an anotation at 4:23 that shows that the spicules are

[NaderMeloN]

Well, in the first part You have already answered my question, great that was what I was looking for. I mean unofficially we could refer to a process like intramembraneous in the endochondral process.

Great thanks much again... : )

[NaderMeloN]

Just one thing you might know: we say that the Endochondral bone formation also includes the Intramembranouse bone formation as one of its steps. is it in the begining or at the end of this process?

if you might happen to know. Really appreciate this.

[hpdutra]

@NaderMeloN Intramembranous ossification occurs when mesenchymal precursor cells differentiate directly into bone forming cells. In that sense you can say that at the formation of bone collar and immediately after the periosteal bud invasion there is some intramembranous ossification. However, I am not aware of any book that actually describes Intramembranous ossification as a step of endochondral ossification, as they form different bones in the body.

[hpdutra]

no not yet. Endo means within and chondral means cartilage. This process forms bone witin a cartilage mold. The perichondrium (arond the cartilage) has cells that can differentiate into bone forming cells (osteoblast) that make a bone collar. Osteoblasts need to get to the core of the mold to form bone from within. T

[hpdutra]

The only way to get to core is through blood vessels invasion, they call this invasion of the periosteal bud. This invasion creates the primary ossification center. In which cartilage gets calcified then replaced by bone. The same process repeats at the extremities becomiing the secondary ossification process. Beware that calcified cartilage is not the same as bone. Bone is formed by osteoblast only, so you cartilage need to be calcified, absorbed by osteoclasts before bone is formed. 

[NaderMeloN]

this was absolutely great, thanks much. but have you also got any video like this about "Endochondral" Bone formation as well...???

[hpdutra]

@NaderMeloN

no not yet. But I can answer any questions you may have

[hpdutra]

Let me know if you have any questions!