Cytotoxic T Cells

[MsRsclips]

i'm doing still fine with lung cancer :) sometimes pain in the chest and can't breath really great but :D

[MsRsclips]

Don't make jokes about cancer please think about how it would be like if you had it i'm having lung cancer right now and i am having the maximum pain you can get right now and i'm on youtube...

[7735jay]

@MsRsclips i am sorry you have lung cancer but i am quite sure Mr. Khan was not trying to minimize cancer he was trying to show us the students how a cell infected with cancer would show itself on the cell surface. Realize also that he is not showing his face, using a pointer etc. all he has is his voice so he has to do different intonations to make his point.

[ronzaarraf]

God bless u

[DonnaMoii]

04:38



[gurllovehim]

the 1 dislike is from the cancerous cell that is supposed to be kill by cytotoxic T cell...hahaha!

[jjclassjj]

very interesting thanks

[nathuwjohn]

Excellent videos! Thanks!

Now, could you come take my test for me?! ;)

[zuay9016]

so these are what i've been learning in my lectures all this while!!thank you! u make my revision more enjoyable :))

[Nirvana87]

How can someone possibly dislike this??

Awesome teacher!

[EvelynNLB]

your the best!!

[8th0monkey]

your video on immune subject makes me enjoyed to learn immunology...i have an immunology exam tomorrow and watching your video makes me want to learn more....thank you so much salman~~~ = D

[AznsrAwesome]

10 minutes before my test and I finally understand this material

[tiggs1792]

I love your lessons. I have been watching since my freshman year in college. Very helpful and I recommend them to all of my friends in my similar classes.

[Elnora4ka]

Thank you very much for your helpful lessons! God bless you!

[zeb120]

nuclei

not nucleuses

[ghost2me]

hey shady guy!!

love these videos so much!!

thanx a lot!! :D

[Giesinger07]

THANK YOU FOR ALL YOUR VIDEOS, I just aced my first immunology exam :)

[themexiranian]

i just like that you are drawing things out and explaining them, rather than pointing to an unmoving ppt presentation thats been molding around for years and years

[xTR1ZZY]

i've been infected, i am cancerous, i'm going nuts, YOU BETTER KILL ME!

[ghoshsurajit85]

This is an amazing video and exactly what i wanted to know regarding the T cells. so thanks a lot for the pleasent lecture.

[Donau005]

Thanks alot...This is great :) Although.. Neurons (Nerve cells) doesn't have MHC-I receptors on them. (?) Isn't that correct? But except for that one type of cells, all nucleated cells DO have MHC-I receptors..

[cherrycoke8464]

Thank you so much for these videos Sal, you made me just a little bit smarter today. And you didn't bore me in the process. Big ups for that!! :D

[bl3owns3all]

Seriously, good stuff. Now i have more hope for my finals. :)

[ochoamv]

I love this... so helpful and clear.. great study tool for finals

[2caasolb]

fantastic videos!

... dey took er juuurbs!!

[TheDeqaOmar]

u r the best. Mansha allah

[General0208]

Mhc 1 for cytotoxic. Cells

[mizmoe81]

I am SUCH a visual learner! Thank you thank you thank you!!!

[wlsgh50]

Thanks alot ^^

[jahu198]

Thank you so so so much! I didn't understand a word of what they talked about at uni and now I get it. Well, at least the basics, but that's more than I ever thought I'd understand. (Especially with a teacher with a strong accent). Thank you! You're awesome! :)

[aly7792]

Your the best teacher on youtube,like seriously..May Allah bless you

[cherrytehhladyy]

i'm so slow at understanding processes like this, thank you ! it was so easy for me to connect with this .

[MrPyrhana25]

Best life sciences videos on you tube. Great logic of sequence!

[Pangjunmin]

i can finally understand! my group spent so many hours trying to understand what the heck was going on, this simplifies it so much that i can teach it to them now :D

[review424]

I'm study for the mcat off of these videos. I thought I'd make a review sheet for myself and for others! Enjoy!

tinyurl

.com

/review424-4

Sorry for the messy url!

[1006Will]

Hey Buddy, thx for your vids..but you should really make some high level immunology vids just for professionals.

[supadave2103]

these videos are wonderful...everything is clear and organized...i understand everything through these videos...genius...thank you!!!

[mathamri]

" i am cancerous! i'm going nuts! kill me!"

hahaha!

[in2ennui]

Your teaching skills are AMAZING!! Very unlike my own professor... I seriously learn better from you than from sitting in class where a teacher reads slides! Step by Step drawings and words are an enormously effective technique!

[lean84]

@in2ennui "...sitting in class where a teacher reads slides! ..." sounds like one of my classes :p

[kareemapollo]

great job khan sahad

kindly expand u r area of teaching by including medical sciences

[in2ennui]

@kareemapollo I TOTALLY agree, could you expand into...say physiology...

And in your video you say that we can learn the rest from our immuno course...but could you possibly BE our immuno course;0 

[kareemapollo]

great job khan sahad

[sportzgyal01]

you always choose a dendritic cell to explain examples- like the fact it helps wake up the adaptive immunity by displaying the antigen. what about macrophages? how do they participate with the adaptive immunity?

p.s. love your vidoes!!

[mustafaib]

Thanks

[addycastro]

How does a B cell decide whether to display MHC I or MHC II with an antigen?

And if it does display an MHC I + antigen complex does it get destroyed by Cytotoxic T cells? Kinda confused..cause that would kinda be counterproductive.

[babyshamblez]

@addycastro @addycastro B cells display both MHC 1 and MHC 2. the antigens are presented on MHC 2 because the antibodies coating the membrane of the Bcell have attached to a foreign particle. this particle is then engulfed, lysed and some of the protein debris is presented on the MHC2 on the outside of the cell so the Helper T cells can come and help produce antibodies. MHC1 complexes only have antigens presented on them when a foreign body enters the cell without being engulfed...

[babyshamblez]

then this tells the Cytotoxic T cells that the cell itself is infected, not that it found something floating around in the body. 

[boonlorify]

Extreamly helpful!!!! I'm in med school and he explains it better than the book and/or the professors!!!!

[Arilaynne]

Your vids are truly great.

But i'd like to add that thrombocytes are also not nucleated

[Leon2101]

Hello Salman Khan!

I love ALL of your videos!!

May Allah grant you good health, so that you can continue educating the world.

Congrats with the 2 million dollar from Google.

[mmcindy33]

LOL!!! "kill me kill me!!! I am a virus making machine, you better kill me!!'!! omg i love this!!!! <3

[VenezuelanDude7]

I've been infected! I'm cancerous! you better kill me, i'm a virus-making machine! i'm going nuts, kill me already!

haha that's so funny. Great video

[weareborntodie]

hi can you do one to explain the difference between different types of vaccines? Thanks lots!

[LoserMcBeaver]

How do you know all this?

Seriously you know everything from maths to bio to chem!

What degree holder are you?

[belisima7]

thank you! I finally understand what my professor has been talking about for the past 2 weeks

[pokuneff]

You are a gifted and brilliant teacher. thank you so much!!

[trustjess]

You are the best thing that has ever happened to me! Maybe now I'll pas A+P II

[stardanny33]

I have a question...when you say the DNA gets shuffled around...do you refer to the post transcriptional modifications of pre-mRNA (exon splicing combination's)?

Because I don't think DNA can do that. THANKS

Great video btw!!

[Sameer3292]

@stardanny33 He is referring to alternative splicing. Different ways to splice out introns creating different sets of mature mRNA to be translated, thus giving off different proteins. Also, it gains more variance through post-translation modification, such as different forms of sorting and glycosylation at the golgi before being presented on the surface. Hope that helps.

[stardanny33]

@Sameer3292 Thanks, thats what I thought as well. 6 month later response lol

[Zturn]

You said "MHC I will appear on every nucleased cell".

Then for red blood cells that haven't nucleas were destroyed?

or because MHC I on RBC membrane wasn't destroyed when RBC' nucleas disappear, so RBC were survival?

please correct me, thank you very much.

[stardanny33]

@Zturn

RBCs don't have nuclei nor any organelles like ER or mitochondria. So they don't have an MHC I.

But they get degraded in the spleen every ~120 days

[qteshorty634]

sweet!!! this helped a lot for my microbiology class I wish all the teachers were like you !

[personalvenom]

your videos are absolutely wonderful! :)

i just read my physiology txt book on the lymphatic system for 2 straight days and your presentation just made everything click!!!

love it.

PS: you're awesome.

[XmejanX]

will you be my bio teacher.... PLEASE. mine doesn't teach. thanks for all your help :] wish me luck on the final!!!

[xforestberryx]

this is so brilliant! ty for the upload!

[Thevamily]

lol at 4:56 ..I'm infected... I'm going nuts..u better kill me

[TheButterStick1]

this is a great video i learned a lot. my bio teacher is giving extra credit if we watch these on any Biology subject we like and he thinks your lessons are great.

[ifyc576]

Thank you for the video.  You method of teaching makes a complex subject learnable.

[lotteboyhk]

thanks for all of your teaching

but it is hard to know which is which and their orders

it will be nice if u put numbers in so people knw which one to watch first

it's like in the video when u say, ' ok following from the last video' I do not know which one u mean by 'LAST'

thanks!

[ebonyamberjade]

Another excellent video. I learned a lot

[GoodTunesFtw]

I've never seen ads on his videos.

[Cjrawckstar]

I just wanted to say how much i dislike 40 second commercials before each video.....

[khanacademy]

YouTube just started doing that. It should be off now.

[2much2teach]

I never seen them, use Firefox with adblock plus

[superc]

everybody has got to pay the bills. If you want to eliminate commercials, donate to khan's efforts.

[AnotherBrownKid]

@Cjrawckstar big fucking deal you pussy

[superc]

hello sir, i don't think this is the appropriate clip to comment this to but may i ask if you are planning to have lessons on Grammar, Composition, and Creative Writing (like writing styles and diff. sentence structures)? Your approach is great. THanks very much!

[lloplop]

I second the grammar video!

I really really love these videos. they help me tremendously.