cAMP Signaling

[kovich2011]

Great video...learning the ABC's in barely two minutes is indeed timesaving!!

[venov92]

regulatory and catalytic subunit = PKA.

[BrockGN]

1. Ligand binds to receptor causing conformational change

2. Alpha subunit of G-Protein (coupled to receptor) releases GDP and binds GTP

3. GTP bound alpha subunit releases from receptor and activates Adenylate* Cyclase

4. Activated adenylate cyclase converts ATP --> cAMP

5. cAMP binds to regulatory subunit of PKA

6. Catalytic subunit of PKA releases and becomes activated

7. Activated catalytic subunits now phosphorylate target proteins

... this is not the human bio i wanted to learn

[jonseyboy91]

I love Biology

[lindybindyify]

Why does she have to talk soo fast!!!

[Quadraticfunction]

IF YOU THINK THAT ALL BIOLOGY PROFESSORS DO NOT KNOW HOW TO TEACH, THUMBS UP!!!

[Puma297]

@Quadraticfunction Shut up Meg.

[shradxc1]

good one! i think i understood something :P

[DrZB345T]

I'm in HS and I understand this.... I looked up a video simply because I take AP Biology as an independent course and my teacher hates me :D

[UltimaNinjaK]

.................... am i really this bored?

[linghowwashere]

i dont get whats so hard? u guys are obviously in high school or something if u dont get it

[31reggiemiller1]

shit a brick im fucked

[Splinter479]

cyclic-adenosine-mono-phosphat­e-dependent-proteine-kinase ....

W T F !?

[kye222]

lol, easy as fuck. whats there not to understand.

[crazy0christoph]

the funny thing is that this is greatly simplified.

[djgrekos]

imma phosphorylate CRAP

[madeline149789]

TOO FAST

[markytproctor]

Great explanation simple yet precise! Many thanks friend!

[markytproctor]

Great explanation simple yet precise! Many thanks friend!

[mekmedful]

great animation thanks

[Altruism1990]

uft.

[helixzzz]

DAMN NATURE, YOU SCARY!

[Elliebean1314]

@helixzzz haha yes it is

[mexicanfish21]

didn't mention Epac....

[codnono]

Is there any video with c-myc and p53->p21 activation? this was good, but not what i was looking for.. should be the same signaling or maybe it was Wnt...

[SamanthaBland17]

your videos are incredibly helpful and well done. thank you so much for making them available to us! my only suggestion would be to speak a little slower; although your voice is clear, i think the information would sink in more if you spoke slower or made slight pauses in your narration. :) thanks again!

[pirozhok88]

This vid is a life saver... I've been reading books for hours and none really entered my brain..lol

[ChainAlgorithm0]

oh god thank you so much... makes sense now.

have my babies

[MrDrunkenTiger]

nice video looks like i got this since i understand every step

[1uPmExIcAn]

if you cant understand this, then medicine is not for you my friends.. ~

this is VERY basic... pages and pages of research can come out of this single process heheh

GREAT VIDEO! just surfin around hahah

[WellConditionedChimp]

how do you go beyond memorizing this? how do you use this information practically?

[TimmysMummy]

@WellConditionedChimp I can give you one example, in the intestines, cholera can produce a toxin which blocks the alpha g protein subunit, so it remains active without the need for hormonal stimulation of the receprtor. Because the alpha subunit (the green bit in this video) is always active and cant be switched off, adenylyl cyclase is constantly making cAMP which is responsible for the loss of electrolytes and water into the intestinal lumen (produces watery diarrhea).

[WellConditionedChimp]

@TimmysMummy thanks

[wudgee]

superb thank you

[janitarjanitar]

awesome

[maulingzebraz]

... w ... t ... f ...

[gexman31]

@maulingzebraz lololol

[G7Alex]

looks like i am gona fail tomorow in the exam...

[TimmysMummy]

@G7Alex how did the exam go then?

[G7Alex]

@TimmysMummy could have gone better..lol

[Doug6446]

Vai me ajudar na prova de BCM!srsrsrsrsrsrsr Fantástico!

It's going to save in the Molecular Biology Test!

[sofmak]

very very helpfull thank you ;)

[azngracefulgirl]

i have this book, but ... i cant find my CD

midterm is tomorrow

[samiaaaaa1]

yes true saves time from reading and still you can not undertund it

[mollyharrism]

Thanks , that saved me at least a hour or two of reading.

[somebodycalledsaba]

Thank you so much for posting this video. We're learning about this and g-protein coupled receptor signaling in neuropharmacology right now and I was so confused! This helped a lot. :)

[locodream]

Tks

[kleenexz]

thank you so much. god bless. this really helped me

[cherrymartinii]

this video gave me an A in signal transduction :)

[danieldfm31]

!que bien¡ pero no tienes un video para las demas funciones de la proteinaG, como la de la relación con la glucogenolisis o la lípolis. de todas formas felicitaciones por el video

[Andrew25367]

this is really complicated