Lorenzo's Oil [Part 3]

[ExplosPlankton]

The crying on the steps is way over the top...and Nick Nolte's forced accent is awful

[TheBermudaMan]

@ExplosPlankton I feel it's a difficult scene to judge. When you're completely mad with grief, there's no way to predict how you'll behave. Sometimes people shed one tear and move on, other times they go berserk. I don't find the father's reaction here unbelievable in the slightest, but that's only my own take on it.

[xoxlithium]

@TheBermudaMan I completely agree with you

[heathirving]

@TheBermudaMan

exactly,not only for the fact that he will lose his only son,but also the terrible,terrible way he will die,a very accurate scene imho.

[kobedabestxx]

ohhhhhhhhhhhhh

[Davrainbow]

That actor is so amazing how he puts all of his emotions into the acting... :,)

[peglegmegg16]

The beginning is scary :O

[ChaffyGlitz]

''It's the cruelest kind of genetic lottery'' sad

[RCSPokemon]

Does anyone else think that the child who played Lorenzo did an absolutely fabulous job?

[fernandatralala]

@RCSPokemon I do!

[Disconn3ction]

FUCKING DON'T PUT SPOILERS IN THE COMMENT.

[PrettyTiaF]

The music in this movie is really annoying. Whats really funny is that my psych teacher had stopped the movie because of a fire drill or something and then when we resumed the video it was paused on Nolte's face with his mouth open--it was HILARIOUS! so random that he just fell down the stairs like that. Im suprised mostly everyone's got my humor:)

[dnurbina]

This is a great movie to apply the cientific method for all people are not a cientific... congratulation for all family to want his son.

[SonikkuForever]

Yes, the real Lorenzo lived into adulthood, and his condition wasn't even what killed him. He contracted aspirational pneumonia after inhaling some food.

[heavymtal94]

I laughed when he was crying and fell down the stairs

[DanTelebi]

@heavymtal94 i had to watch this movie in 8th grade and i think everyone in the class laughed at that part lol

[xoxlithium]

@heavymtal94 thats fucked up, asshole

[Jujuman2003]

I love Nick Nolte pretending to know what the hell the Italians were talking about in that scene.

[GodsGirl8844]

Im crying cause im thinking about if i was older and had a kid that had that i would have done the samething that the dad thing..i would have just burst into tears :'( and it is AMAZING that the real lorenzo lived till 30 <3

[kbonilla100]

So lorenzo really died wow !!!!!!!!

[metalsnake27]

@kbonilla100

Trollolololololol

[daniel1982]

I have ALD. Experienting ẃith a diet of gin, coffee and tobacco.

[ClickForOutkast]

@daniel1982 For real?

[daniel1982]

I have ALD. Experienting ẃith a diet of gin, coffee and tobacco.

[little80skidfunk]

@maverickX54 Not Funny.

[SonaShegoIdAniSuAur]

@little80skidfunk it is really funny did you see how the retard fell down the stairs while crying. Also the paper clips nightmare what the hell was that shit!

[Elipito5]

If his parents ever read this, I admire you for going through this and being strong. May God be with both of you and I hope you live beautiful lives. Your son's memory will live through all of us forever.

[MiyahSummer]

I always gets me when I see him looking at the symptoms..

[Kellox17]

diseases are so weird, the woman are safe they can just carry it but men are effect and tcould die before the age of 10

[ExplorerDS6789]

How do you pronounce Peter Ustinov's last name? Is it "You-stinov", "Oo-stinav"? 

[SonOfDragonflyz]

@ExplorerDS6789

the last one.. U like oo in zoo.. oostinof if you would like to type it ^^

[Kogerii]

Wait, if it's carried on the X chromosome wouldn't the father still have half a chance to carry it? It doesn't make sense to say it's carried on the X chromosome but a man can't have it. I guess the boys with it would die before reproducing.

[Flipitiflop]

@Kogerii The way sex linked diseases work, is that if the woman is a carrier, she carries it on one X chromosome. However, she has another 'normal' X chromosome to cancel out any effects ie, she would need the defect on BOTH X's to actually have the disease. So she has a 50/50 % chance of passing the gene on. A male, because he is XY, if he inherits the defective X chromosome, he has no other X to dominate/cancel the defect. And so all males with the defective X would actually have the disease

[Flipitiflop]

@Flipitiflop It's the same with colour blindness. The only way a woman can be colour blind is if her father is colour blind and her mother is a carrier and she inherited the X chromosome from her mother that carries the gene. That is why the majority of people who are colour blind are male. Also, in this case, because ALD kills suffers before they are old enough to have kids, it means you technically can't get girls with the same disease.

[Kogerii]

@Flipitiflop

I knew that but the mistake I was making in thinking was even dumber. Lorenzo didn't get an X chromosone from his Dad, duh. 

[incartato]

it is a comic scene!

[zgrillo2004]

Very sad movie. I feel so sorry for mr. and mrs odone for their son's death. I give my regards to them

[NikiiixLHS]

We watched this movie in science in 9th grade. It's truly the best movie that I have ever seen.

That boy's lucky that he has parents like them.

[SonaShegoIdAniSuAur]

@NikiiixLHS mrs siglers class

[NikiiixLHS]

@SonaShegoIdAniSuAur hahah. uhhhh. no.

[xSnapeSoulmatex]

....LOL oh my god the beginning

[thenolansrocktonight]

aww

[juliabohemian]

Very powerful and realistic. People lose it when they find out their child has a terminal, demylenating disease.

[xxcupcake113xx]

dose anyone else find the beginning kinda disturbing?

[xxcupcake113xx]

and unnecessary

[xSnapeSoulmatex]

@xxcupcake113xx XD yes

[ciccicasillas]

@xxcupcake113xx

i don't, that's real life, splatter films are disturbing, and totally useless, This is just a film on extreme real parental love

[thedrmat]

What's so funny about it?? Maybe I am so dumb I don't understand, and you could illuminate me and the rest of all "dimwits" who have been moved to tears by that scene.

[Squishyxo]

this is a fairly disturbing movie but truly a mircle. <3

[doc105]

watched it in biology  soo sad

[xDaRkBeAsTxx]

i know i watched it today this shit is sad

[noagori]

no they're dead, they're blogging from beyond the grave! ;p

[fuxmesidewaylol]

good movie

[Krastev23]

They had to give Augusto the Nobel prize....

[ExplorerDS6789]

@Krastev23 Well, if they HAD to.

[LadyFringe]

Unfortunately girls have something similar to this called Metachromatic Leukodystrophy (MLD). I know this because my best friends granddaughter who is only 8 years old was just diagnosed with this disease.

[Longhorn959]

Yes, I have to use Lorenzo's Oil every day. And yes I live a nearly normal life, I still play sports and go to school just like many others.

[liszt80]

Nolte's italian is very bad... :)

[redskinsfreak614]

Agreed

[GIROBOTII]

@liszt80 Ohh, is he supposed to be Italian? Are  you Italian?

[MrsNemonina]

@GIROBOTII well, Nolte tries his best ;) If I would try to speak italien, it would sound worse. So, go for it, Noltione!

[JustmeKasie]

nvm lols

[JustmeKasie]

why does this disease only happen to boys?

[ratlover35]

it's some kinda gene thing that guys have but girls don't...i feel good about periods after seeing this XD

[JustmeKasie]

haha yea :) phew!

[Floralin]

LOL like periods are the worst thing that could happen to women . I actually feel good everytime i see them , cos it shows m somehow healthy .

Men have to shave everyday .Ain't that a bitch ?

[rorabokele]

it only happens to boys because ALD is X-linked and boys unlike girls have only one X chromosomes (XY) while girls have two XX.

So if something goes wrong with one gene on the x chromosome of a boy like in ALD (something is wrong with Xq28) he expresses the disease unlike a female who has a normal second gene on the other x chromosome that can be expressed you might ask what if both are bad on a female well i have no answer to that and i think such embryo may not even live to reach feotal stage

[noagori]

in extremely rare cases females get it

[aroogooy123]

This disease is only passed on from mother to son, because since females have two X chromosomes, and ALD is a recessive gene that effects X chromosomes, females do not inherit the disease. Since males have both an X and a Y chromosome, the recessive disease is apparent.

[ferrdz74100]

The father is the one who looks like having a seizure!! haha

[donnie2164]

there is a movie called (First Do No Harm) its based on true events, Very good

[Egyptfanatic]

Oh god...imagine the pain that woman feels, seeing her beloved son go through such pain then finding out she's to blame?

[Floralin]

well she also gave him life , didn't she ?

[ciccicasillas]

@Egyptfanatic

no one is to blame, did you ever choose your own genes??

[faceofjesusinmysoup]

Spinach has saturated fat? I don't think so!

[lluvia189]

are u a doctor or a nutritionist to belive that?

[zuulam123]

I LOVE THIS MOVIE!!! SO SAD, omg a tragic to have this type of rare disease back in the 1980's :(

[makenna88]

is that phillip seymour hoffman?

[lauracollegegirl05]

I am in the early childhood program in college. We were learning about mylein. That is something that the doctor talks about in the movie when he describes what they know ALD. Someone in my class said that this movie was a good movie so I watched it on TV and it was really good and I felt like I could cry.

[cenalover386]

i watch this movie every time it comes on tv and i never knew that the real lorenzo odone died at age 30

[faceofjesusinmysoup]

amazing he lived that long!

[swaggercheco]

@cenalover386 THANKS FOR RUINING THE MOVIE DIPSHIT!!!!!!!!!!!!

[cenalover386]

@swaggercheco i did a project on Adrenoleukodystrophy and found out about him IT WAS NEVER MENTIONED IN THE MOVIE ASSHOLE!!

[swaggercheco]

@cenalover386 eat a dick dum shit

[cenalover386]

@swaggercheco suck on one bitch!

[iii7joseph7iii]

i never have seen this movie until th 4th of feb 2009

belive me i cryed silently

to come a cross this journey is undiscribable by me all of you not even by the cst of the movie

only those who lived thourgh that can !!

that movie show me how a humen could be so week nd in the same time so brave .

This move is so inlightning to all of us

[grizby2]

whats the song during the first few seconds of this video? i really want to know :O

[aartie]

It's called "Adagio for Strings" by Samuel Barber.

[JaegersQueen]

such a sad movie i watched this in biology and anatomy and physiology, this made me cry

[tinkabella211]

i watched it in my biology class it made me cry too