Chromatin, Histones & Cathepsin

[mattywake]

That video was so good I pretty much just jizzed in my pants

[stickmanup123]

why is there music :/

[microwave103]

Amazing vid, PROPS

[tatoua114]

excellente video ki m'a bcp aider a comprendre!

[jimsac2000]

thanks for posting!

[BaffledMath]

Very useful!

[claudiorivetti]

3D graphic is very powerful but please don't forget the basic roles: DNA is right-handed not left-handed!

[suryachawdhary]

this is super cool, it made so easy to understand! thanx

[kleopatrab]

great video

[YuRiPrem]

issit 2 turns around histone octomer or 1.75 turns? what i read was 1.75 turns = =

[Elliandr]

Epigenetics plays a bigger role than that. On the Galapagos islands, different species of finch were found to be genetically identical. It is Epigenetics, not random mutation, that adapted their beaks differently depending on the food source. While Evolution as random mutation can not be proven, Evolution as Epigenetics can be observed. If a specie changes in response to an environmental need, the gene expression changes are not random at all but the result of individual choice shaping nature.

[sickbay]

This video was paramount.

[MaiaDulce]

BUEN VIDEO :)

[wudgee]

Excellent. Love the music too - relaxing. This has cleared up a couple of things for me, thanks.

[mountom]

2 minutes video vs 30 minutes of reading & feeling retarded...

thx ^^

[Wyldeck]

explained very well with good animations

[LukeGeoDude]

and big thanks for the video, very interesting.

[LukeGeoDude]

are nucleosomes made from is it 146 base pairs or 166 base pairs? my book says 166, but book from a certain Canadian author says 146.

[thriler30]

@LukeGeoDude it's 146 pairs wrapped around histone octameres +60 more DNA pairs which are located between each of the following histones, so it's more like 146+60=206 pairs for each nucleosome

[thriler30]

@LukeGeoDude it's 146 pairs wrapped around histone octameres +60 more DNA pairs which are located between each of the following histones, so it's more like 146+60=206 pairs for each nucleosome

[karotaki001]

brilliant! thanks

[studywithvidz]

awesome! Best video on the compacting process!

[drvasquez69]

Is thhis college lvl bio?

[dildeanum786]

@drvasquez69 yes it is :)

[DrSpence1]

Ohhh so that's how all that DNA fits in that little nucleus



[Nosforit]

The music is inappropriate, triggering all my switches to stop listening to infomercials. Luckily the illustration more than makes up for it.

[lykfe]

damn i'm done studyin!! just by watchin this

nice music too!!!

[syidlive]

shit man this is awesome

[confucius2006]

I love this. This is wonderful!

[jazzmastaj]

man i love these sci-fi looking videos, if anyone knows of some good molecular biology ones similar to this one please let me know where to find them. This animation is really helpful :)

[wasbeermeneer]

Look up: "The inner life of a cell", by harvard biovisions.

There is a short video with nice music, and a long one with comments

[childofreletivity]

good goood good this is great for studieng

[dan314159]

oops posted on wrong video. sorry.

[dan314159]

This is NOT supercoiling! Just the highest order structure of a eukaryotic chromosome. Very pretty and enlightening but it threw me off track until I realised this!

[edmagueule]

nice but they have forgotten h1 histones

[hellofloyd]

H1 is involved in 30 nM chromatin - (One level higher than nucleosomes). Nucleosomes do not contain H1.

[vladvalentinov]

Wow, evolution is so awesomely clever to create such system...

Great visualization, thanks.

[thirdbar]

i agree, God was clever when he made that system

[thevenomous1]

@thirdbar

Well, if you mean God as the physical laws then yes =)

[hellofloyd]

That system was not "made" - it developed slowly to what it is today over millions of years of trial and error. If fact, that system is still not perfect today, and it is still finding ways to become better, by selecting only those individuals who have the BEST systems to procreate, so that future systems will be composed only of the genes from the biologically fittest individuals.

[allan3141]

@hellofloyd idiot

[davisx7]

thank you

[Shrubbs]

Wow, that was an informative and fantastic animation

[RockyBalboa211]

A tad confusing.. but has given me a new view on the material, thank you!

[HaRoS1989]

This video is really great!

[drmrna]

@ LeeDiddy990: Hyperacetylation of histones does not necessarily indicate "overexpression" of HAT and vice versa. Either a gene is inherited in hyperacetylated state or the activity of HAT's is increased by intra- and/or extracellular signals.

A remarkably good animation, thanks!

[arey051012]

Great visuals, thanks!

[kimichii]

super, thanks

[anthonypalladeno]

Thanks a lot, you helped me out a ton!!

[zooalkj]

awesome

[gijs14]

happygenetic :p

[brea87]

All this confuses the crap out of me. Why did I decide to be pre-med? oh why!!?

[LeeDiddy990]

so hyperacetylation is the the overexpression of HAT and hypoactylation is the underexpression of hat or overexpression of HDAC. Im still a little bit confused on that is my thinking correct.

[nitinrao49]

wait, scratch that....where is H1?

[kmcallenberg]

H1 and H5 are linker, not core, histone classes. maybe i dont understand the structure well enough, but it doesnt seem like they need to be included. at what point would you have included them?

[nitinrao49]

amazing video, accurate; appreciate it