Coley developed the theory that it was the infections which had helped patients in the past to recover from their cancer.
So he began to treat patients by injecting a brew of Streptococcus pyogenes directly into inoperable tumors.
The treatment was most effective when it provoked a fever and a full-blown infection.
According to Stephen Hoption Cann of the University of British Columbia, "He had successes you simply couldn't hope for today, curing even extensive metastatic disease."
Dr. Cassian Yee, Drs. Zihai Li and Bei Liu,, William Coley, Victor Ambros, Gary Ruvkun, and David Baulcombe
Researchers have uncovered a way to potentially use human stem cells as a kind of vaccine against colon cancer.
This discovery, led by experts in immunology, Drs. Zihai Li and Bei Liu, builds upon a century old theory that immunizing with embryonic materials may generate an anti-tumor response by "fooling" the immune system into believing that cancer cells are present.
Immune cells in some cancer patient recognize, attack, and kill cancer cells, leading to full patient recovery.
Recently Steven Rosenberg at the National Cancer Institute isolated these cancer kiling T cells (tumor-infiltrating lymphocytes) in a patient who had successfully beaten melanoma.
He then introduced genetic information from them via a harmless retrovirus into the T cells of patients suffering from active cases of potentially deadly melanoma.
"By using a probe to shine a light on the tumour, the antibodies at the right place in the body can be brought to life.
Any antibodies in the rest of the body will remain dormant, meaning side effects can be minimised.
The activated antibodies then cause immune cells in the blood called T-cells to attack the cancer."
"Just a few minutes of the light therapy directed at the region of the tumour would activate the T-cells causing her body's own immune cells to attack the tumour."
Dr. Engleman, I'm wondering if an antibody can be created specific against PSA. All cases of prostate cancer have tremendously high PSA. This antibody will 'disrupt' this PSA producing cancer cells somehow. I think the PSA in all of these cases are the same and it doesn't have to involve making antibody to PSA for each specific patient. Just wondering if anti-PSA antibody has been created or induced.
This vaccine has been invented by a Brazilian. He's actually patented it and did it as a "public patent". So anyone can use it without having to pay royalties.
Search for A Barbuto on Google and you'll see his documents online.
It's not an American thing. Stop taking credibility for everything good in the world. That is so not true.
I know Dr. Cesar Milstein is from Argentina; then went to the U.K. He won the Nobel Prize (with some other scientists) for his work on this field of monoclonal antibodies. Talent is everywhere really. The U.S. just happens to be the 'rich boy' on the block who can attract a lot of talents, the funding, and the free environment to let the mind wander. This monoclonal antibody was produced from hybrid cell (hybridoma) - cancerous myeloma cells and plasma cells.
The FDA and Pharma are in bed together. Polyclonal antibodies would be much more efficient therapeutically. They know very well that the body is too complex too respond to single agent drugs and drug targets. Its their narrow-minded (possibly deliberate) stubborness that is stifling progress in cancer therapy. They WANT to keep chemo as standard therapy. Why? Because using chemo makes this industry a $200 billion per year industry. The drugs required to manage side effects are several, & pricey
Thanks for the great lecture. As he said, there's a lot that needs to told regarding governmental policies and the economics of healthcare. The one thing that's true for all branches of science is that scientists are the ones who do all the hard word and come up with brilliant solutions, but in the end, the average person cannot benefit from all this because money-minded investors who know shit about science just can't forsake the least opportunity to make more profit. The bastards.
If this vaccien or these vaccines were shown to be effective, it would be a world first for a vaccine to actually prevent a disease. The chances of this being the case would be astronomical. I recommend we don't hold our breath.
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Coley developed the theory that it was the infections which had helped patients in the past to recover from their cancer.
So he began to treat patients by injecting a brew of Streptococcus pyogenes directly into inoperable tumors.
The treatment was most effective when it provoked a fever and a full-blown infection.
According to Stephen Hoption Cann of the University of British Columbia, "He had successes you simply couldn't hope for today, curing even extensive metastatic disease."
sn1pe352 1 week ago
NOTE :
Dr. Cassian Yee, Drs. Zihai Li and Bei Liu,, William Coley, Victor Ambros, Gary Ruvkun, and David Baulcombe
Researchers have uncovered a way to potentially use human stem cells as a kind of vaccine against colon cancer.
This discovery, led by experts in immunology, Drs. Zihai Li and Bei Liu, builds upon a century old theory that immunizing with embryonic materials may generate an anti-tumor response by "fooling" the immune system into believing that cancer cells are present.
sn1pe352 1 week ago
This has been flagged as spam show
Immune cells in some cancer patient recognize, attack, and kill cancer cells, leading to full patient recovery.
Recently Steven Rosenberg at the National Cancer Institute isolated these cancer kiling T cells (tumor-infiltrating lymphocytes) in a patient who had successfully beaten melanoma.
He then introduced genetic information from them via a harmless retrovirus into the T cells of patients suffering from active cases of potentially deadly melanoma.
sn1pe352 1 week ago
This has been flagged as spam show
"By using a probe to shine a light on the tumour, the antibodies at the right place in the body can be brought to life.
Any antibodies in the rest of the body will remain dormant, meaning side effects can be minimised.
The activated antibodies then cause immune cells in the blood called T-cells to attack the cancer."
"Just a few minutes of the light therapy directed at the region of the tumour would activate the T-cells causing her body's own immune cells to attack the tumour."
sn1pe352 1 week ago
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very informative video! thanks for sharing this video.
adelle0001 2 months ago
Props to Stanford for making a documentary.
grunder20 2 months ago
This is a great breakthrough. It will give hope to many people.
agapitoflores001 2 months ago
good
ILMEDICINE 3 months ago
Dr. Engleman, I'm wondering if an antibody can be created specific against PSA. All cases of prostate cancer have tremendously high PSA. This antibody will 'disrupt' this PSA producing cancer cells somehow. I think the PSA in all of these cases are the same and it doesn't have to involve making antibody to PSA for each specific patient. Just wondering if anti-PSA antibody has been created or induced.
MannyHMo 3 months ago
Comment removed
LavaShark44 4 months ago
This vaccine has been invented by a Brazilian. He's actually patented it and did it as a "public patent". So anyone can use it without having to pay royalties.
Search for A Barbuto on Google and you'll see his documents online.
It's not an American thing. Stop taking credibility for everything good in the world. That is so not true.
vitormangraviti 6 months ago
@vitormangraviti
I know Dr. Cesar Milstein is from Argentina; then went to the U.K. He won the Nobel Prize (with some other scientists) for his work on this field of monoclonal antibodies. Talent is everywhere really. The U.S. just happens to be the 'rich boy' on the block who can attract a lot of talents, the funding, and the free environment to let the mind wander. This monoclonal antibody was produced from hybrid cell (hybridoma) - cancerous myeloma cells and plasma cells.
MannyHMo 3 months ago
well done lecture !
tortaros 1 year ago
@tortaros
Very clear and thought provoking indeed !
MannyHMo 3 months ago
The FDA and Pharma are in bed together. Polyclonal antibodies would be much more efficient therapeutically. They know very well that the body is too complex too respond to single agent drugs and drug targets. Its their narrow-minded (possibly deliberate) stubborness that is stifling progress in cancer therapy. They WANT to keep chemo as standard therapy. Why? Because using chemo makes this industry a $200 billion per year industry. The drugs required to manage side effects are several, & pricey
vitaminboss 1 year ago
Thanks for the great lecture. As he said, there's a lot that needs to told regarding governmental policies and the economics of healthcare. The one thing that's true for all branches of science is that scientists are the ones who do all the hard word and come up with brilliant solutions, but in the end, the average person cannot benefit from all this because money-minded investors who know shit about science just can't forsake the least opportunity to make more profit. The bastards.
Prearius 2 years ago
56 minutes!!!!!!!!!!!!!!!!!!!!???????
bigfastfood 2 years ago
If this vaccien or these vaccines were shown to be effective, it would be a world first for a vaccine to actually prevent a disease. The chances of this being the case would be astronomical. I recommend we don't hold our breath.
vaccineshurtbabies 3 years ago
Can dendritic cells also be used to creat a vaccine for HIV?
DirzoRasec 3 years ago
Excellent lecture!!
starboy31 3 years ago
Sharp guy.
MrFrankBullitt 3 years ago