MDAI - Chemistry Behind the Headlines 3

[emsagro12]

Personally I doubt that there will ever be such a problem with occasional use of MDAI, but purity is another concern. In the absence of regulations, I would not be surprised if manufacturers have no clue what they are doing, and online dealers cut the substances with whatever they have in store.

[HonorEtFides]

Excellent and informative video.

Note: If you are going to use music from an independent band that publishes under its own record label, then please give them the appropriate credit in your opening comment as you did in some of your other videos.

[TroutMaskReplicaa]

It's odd that, in a supposed civilised and intellectual society, anything deemed a drug is immediately demonised and pounced upon. The government use it as an excuse to peddle more of their scaremongering tactics... indoctrinating a dissatisfied public with fear. It isn't odd that the whole mephedrone debacle happened around an election shifting public opinion off unemployment, recession and toward a 'scary, scary drug that will kill you if you even touch it'. Drugs aren't intrinsically harmful.

[SolutionDevil]

cool laptop bro



[sjingelling]

you are great!! acurate info , thx for sharing your knowledge ^^ i just love it

[nadskofhqwak]

i binged hardcore on this shit for 3 days. tried to commit suicide afterwards.. the comedown is just as horrible as e's comedown

[SethJosephThompson]

Makes me sad that fen phen was banned was an amazing treatment for autism spectrum disorders.

[poztpwned]

Awesome video my man. Awesome information about the 5-HT(2b) receptor activity, brought some important info to my attention that should be brought to others' attention as well (unless they want to risk their own heart).

[djparnate]

LOL PHEN PHEN THATS OLDSKOOL PHENTERMINE

[MrLovefile]

i have used it,it was a replacment for mephdrone then nrg1 that band,now mdai,so ALOT of pepole using this as meph replacement,very weak but id still be warey

[macanix]

FFS.... Can't you talk without waving your hands around like a beatnik on speed???? You look like you've just been on a "cheap & nasty" public speaking course...

[apick34]

gd videos. helpful shit

[whiskey01]

MBDB is serenity !

[1giblesp]

If MDAI is banned, the manufacturers will release something else as a 'legal high.'

The government policy of criminalizing drugs is a waste of money and in effect, leads to people trying other potentially more dangerous drugs marketed as legal.

Ecstasy taking is a part of mainstream culture. It would be far safer for young people to take something that was regulated, with clear warnings, rather than take an unknown pill form a street drug dealer.

[mayhemtv]

@1giblesp so true...

[whydoesthismattr]

@1giblesp for real and the gov ernemnt could make so much money off of it with millions of people taking mdma eacj and every weeeksnd. much higher revenue then how many people get busted from it. Lol

[bloddyjoka]

@1giblesp  free the weed

[Alfourthousand]

I think they use this in "Blu-e"

[Meatlock]

Do one about ketamine!

[cigarboxblues]

How can this report possibly be accurate when you are using Nicholl's research on 3,4-Methylenedioxyamphetamine (MDA) CAS number 4764-17-4 not 5,6-Methylenedioxy-2-aminoinda­ne (MDAI)CAS number 132741-81-2. These are two completely different chemicals and your misinformation could do more harm than good!

[ProfessorDaveatYork]

@cigarboxblues

The paper I used which carries out the cardiotoxicity study does discuss and focus on MDAI (although other potential drugs are also considered in it too) - I am well aware of the difference between MDA and MDAI and was careful in navigating the scientific literature to avoid this confusion.

[adamowen30]

@cigarboxblues

it dont matter mate its a lot more accurate than any other info made public

top job keep it up

[FractalRaver]

@cigarboxblues

So this guy is talking about MDA, instead of MDAI? Huge difference (dopamine release). MDA is even more dopaminergic than MDMA.

[Rumbleman99]

i like these vids mate, they're very good, showin the facts about these drugs, no bias just science.

[taar1]

thanks for the video. it was extremely interesting. please continue to cover other substances such as DOI, DOB as well as DMT.

[candydixon]

thats great would never understand those tables on my own thankyou

[u20pricec]

Very interesting, wish my uni lecturers explained things so clearly and concisely. Seems that the next big 'research chemical' is going to be 6 - APB or 'Benzo Fury' this is worrying as i there seems to be even less existing research into the health risks and side effects of this drug. Would be very interesting to see in theory what the side effects could be given the structure of this molecule.

[tru7hhimself]

good video that explains it well to anyone not capable of reading the original papers .

i'd still like to add a point: mdma is a (more of less) potent agonist at 5-HT2B, but doesn't cause widespread cardiac valve fibrosis like fenflouramine, because it's used occasionally as opposed to daily which was the case with prescribed fenf.

so i'd expect daily mdai use to be problematic (because of probable 5-HT2B agonism and 5-HT release), but recreational use ok. of course further research is required.

[ProfessorDaveatYork]

@tru7hhimself This is a fair comment. Interestingly, a paper in International Journal of Obesity (1999, 23, 926-928) indicated that the risk of cardiotoxicity of fenfluramine was dose dependent. Patients who take >60 mg/day were at higher risk than those taking <40 mg/day. Of course MDAI and fenfluramine are completely different drugs - but the typical dose of MDAI is significantly higher at 100-200 mg. The cardiotoxicity risk would then depend on how regular the recreational use is.

[tru7hhimself]

@ProfessorDaveatYork

of course it would depend on how regular recreational use is. i had usage patterns similar to with mdma (i.e. once a month) in mind.

[marmotsrulepwned]

5-HT2B agonism by MDAI is not too probable. Since 5-HT2A agonism is eliminated by the conformational binding of MDA's alpha carbon to yield MDAI (you noted MDAI does not generalize to hallucinogens), and 5-HT2A agonism tends to be a positive function of 5-HT2B agonism, one would expect MDAI's 5-HT2B agonism to be substantially diminished, if not completely eliminated. And, even if it were an agonist, it would probably be less so than MD(M)A, which themselves cause few problems used occasionally.

[shaneholdin]

your videos are great



[MrWitchking1]

I love professor Dave's video's they're so educational! Keep up the good work mate.

[yeyethebois]

It's a catch 44 situation, if u wait 4 conclusive data to be available on a legal high, then by that time it will probs be banned. Anyway I want to say top notch video, I'm very intrigued by this drug as it appears to be alot safer than Mephedrone which I took 1g when it was legal and it randomly gave me a panic attack 3 days later out of nowhere. In my experience, meow causes bad vasoconstriction, bad circulation, overstimulates the heart, but mentally I didn't notice any negative side effects.

[davidsmail1987]

great vid again - very informative. hopefully (like me) it has helped people make more informed decision about these new RCs. keep up the good work!

[TheNutmegman]

Are you aware of Erowid? I never know if any of the chemistry/biology on there is reliable at all......

[lilmissglentoran]

Excellent vid as always Dave and like tourself, I never knew of MDAI and I think as it is mentioned in the NEJM and in the rather splendid open access frontiers in neuroscience series of journals that now is the time for mouse models not to be used in the 21st century as like you said, the toxicity is unknown and this is a area where the animal and human models can be the major factors.

I am glued to these videos and thank you - I am amazed there are all these legal highs on the prowl