Doxycycline as an Agent for "Wound Chemotherapy"

[michalchik]

Somehow I doubt that all these mechanisms are withing reasonable physiological concentrations.

[DrGlassDPM]

@michalchik I believe a few of my cited references describe achieving physiologic activity, especially with topical application (ie wound streaming)

[michalchik]

@DrGlassDPM Thanks, youtube hides the under-bar by default i did not

notice the citations. I will take a look. When topically applied it seems more plausible.

One other point. You mentioned that MP's are necessary at low levels for normal healing. NO is not only a free radical bit also a very effective free radical scavanger for hydroxyl and I believe superoxide. It is also angiogenic, Both those properties would make it valuable in wound healing so long as it stayed within a certain range.

[DrGlassDPM]

@michalchik I couldn't agree more. There's a lot to be desired from future publications in terms of what is "normal" for healing vs non-healing wounds...