Prozac: Selective Serotonin Reuptake Inhibitor (SSRI)

[zibimark]

Credibility "serotonin theory of depression," asks a serious blow to the effectiveness of antidepressant called Stablon that works by reducing the concentration of serotonin in the brain.

[newwoman1124]

Also try adding some changes to diet. Tofu, Most Soy products, Black-eyed Peas, Black and English Walnuts, Almonds, Sesame Seeds, Roasted Pumpkin Seeds, and Gluten flour. My son has ADHD and I felt very uncomfortable with him being on that medication-it's a narcotic. So I tried changing our diet around and I after 2 months I saw a big difference. And he's no longer on the meds. =) That's our experience- ALWAYS CONSULT THE DR. FIRST.

[andrewcubbie]

Prozac is known for things like that.

[tetraheli]

Do not take any pharmaceutical unless absolutely necessary!!  These drugs were created purely out of greed and selfish gain. Do you really think a multibillion dollar corporation cares about your well being?

[emotobot]

Taking SSRIs for 1 week gave me PERMANENT sexual dysfunction. Ironically the loss of my sexuality has made me much more depressed than I was when I first took the medication. I would not recommend these drugs to anyone. The risk is too great.

[asdzxcp1]

Trippy

[WaitAndBleed999]

New research suggests that the miracles promised by prozac may be largely due to the placebo effect....

[xen0nflash]

Protracted/prolonged withdrawal effects from Benzos, SSRIs, etc do in fact resolve in time but it can take months and even years. People who withdrew from benzodiazepines recovered, and benzo withdrawal is 10x worse than SSRI withdrawal. Don't be too discouraged to soon.

[mserenaful]

its true that you have to be really careful and do your research when taking anti's, but in some cases it has saved peoples lives. its naive to say that depression can be fixed with diet and exercise, it takes the pills to help the sufferer to be able to take care of themselves in order to diet and exercise.

[1Nyro]

prozac fucks you up

[marinabroom]

I don't think any of you knows what your talking about. The mind is affected by physical as well as psychological stimuli. If you've ever had depression, that cannot be put down to an event etc you will never have experienced anything like it. Ive had cancer and depression and I would rather have cancer any day.

[eBiology]

@marinabroom You couldn't have said it any better.

[SovereignBeing]

depression can be solved with nutrition... these drugs are lethal and have serious long term complication .. 2 handfuls of cashews contains the same effects as a does of prozac... try B vits especially B3 (niacin) B6, B12.. learn which foods to eat and exercise and try spiritual therapies and energy medicine.. anything natural is better than this artificial prozac rubbish...

[thestackinbills]

@SovereignBeing idiot... nuts will not help depression

[SovereignBeing]

@thestackinbills - health starts with nutrition, put shit in your body and you will feel like shit!! its not rocket science kiddo..!. but if you want to learn the hard way run along to your doctor and get prozac or whatever he;s selling..

Then see what happens ten years after taking them... give me the natural way any day.!

[TomiBT87]

@SovereignBeing heyy can u take omega 3 fish oil b6 and gabba in same time??

[SovereignBeing]

@TomiBT87 - dont know what gabba is...

[TomiBT87]

@SovereignBeing GABBA=Gamma aminobutyric acid

[SovereignBeing]

@TomiBT87 - well i would think so..fish oil and B6 are natural.. u may want to look at a complete B complex for long term use as prolonged use of B6 can put other things out of balance.. and krill is much better than fish these days - no mercury.. see doctor mercola's website.. lots of good info.. exercise is very good for depression also and u can try nightly affirmations.. hope this helps.

[kselzler]

depression is an illness-- just look in the DSM-IV-TR!

[buckheadhobo]

Everything is an illness in the DSM-IV!

Even being stoned is a mental illness. Not jacking off enough is an illness too. Being gay used to be an illness as well.

Seriously, the DSM-IV is for insurance purposes. A psych HAS to diagnose you with something from it every time for insurance purposes. That's why EVERYTHING is a disease in that book.

To understand how Serotonin works, look up the pharmacology of LSD.

[CrispyGreyMatter]

The same could be said for any physical illness.  What's your point?

[stupidtreehugger]

Thank you. Its so good to know human beings still exist, even after millenia of the elite murdering us and farming in their brainwashing.

[SecretSkyArchitectur]

No idea?

Then stfu.

[Energyium]

marijuana is much safer

so are mushrooms

is long as they are used within limits

[priscillab89]

depression is not an illness!!!!

[rickolasnice]

umm.. yes it is.

[jaymongrel]

actually, it's not. There's no test for it; the biochemical imbalance theory was a scam pushed by the pharmaceutical industry. Depression is caused by unhelpful coping mechanisms to psychological stress, usually from childhood trauma.

[cashfan123]

depression is an illness of the mind

[telewebservices]

Depression is a state of mind.

[cashfan123]

haha thats better depression is a state of the mind and no1 but ourselves can heal our own mind i was badly badly down at one point in my life for a long time and the thing that helpd me was a mad book called the secret peace and love to u all

[nanubani]

I agree it seems more a state of mind, calling it an illness only underestimates the power of the mind.

[pantsboy121]

i know prozac is a primary example of an indirect agonist. does it work by blocking transporters or inducing transmitter release? both types of indirect agonists seem to work by inhibiting transmitter reuptake. so what's the difference? i'm confused.

[iamthejake2000]

prozac FUCKED ME UP, stay far, far away from this drug and all other antidepressants.

[cymbalicnumbers]

Did you get permanent damage? I have been screwed by this drug after only 2 pills, 6 months out my mind is aggro and violently racing. Does it end?

[sleestack808]

How are you doing? Did prozac really do this to you? The mind is so delicate it seems

[beautifulbookdork]

@cymbalicnumbers It can't be this drug. This drug takes weeks to have an effect.

[heartattackstroke]

@cymbalicnumbers I am still affected from SSRIs and I haven't touched them in 8 years. I get zaps the same as I did the day I stopped them. Tha manufacturers state the '...the mechanism of SSRIs is unknown, but it is believed that......[unknown?... Believed?]' I do not understand how those guys can get away with that. Scandelous worldwide swindle, almost makes me think there is some sort of a drugnation thought control conspiracy....... ging on around us. PUT YOUR ARMBAND BACK ON!!!!!

[reallysecretusername]

@cymbalicnumbers two pills? that is not enough time to affect anything

[reallysecretusername]

@iamthejake2000 just because it fucked you up doesnt mean that it didnt help others

[Doomguard123456]

i just got out of the shower and im still naked xD h

[running877]

It may be a really bad idea to change your brain chemistry with these drugs in hopes you will feel better. you may feel worse or lose control.

There is a tolerance,burnout and withdrawal with these drugs just like any other.

[dionstrezlecki]

ahahahaha mike tonan-lol nice1

[miketonon]

well sara tonon is a distant relative of mine. i find this absurd that they think shes a brain chemical. completely outrageous.

[mellowmushgrapetripp]

wahts the point in that why not just straight up take serotonin with dopamine and melatonin lol people r so fuckn stupid

[DodgyDeals]

Lol, well serotonin won't cross the blood-brain barrier alone so that would be fairly ineffective - also, high serotonin blood levels can lead to heart failure and valve disease which occurs in some African tribes who eat lots of fruit with high serotonin content...

[DodgyDeals]

And I'm not advocating SSRI's, all I'm saying is that they only increase serotonin within the brain so there is no effect on blood serotonin levels which would also stimulate 5-HT2B receptors in the right side of the heart possibly leading to cardiac fibrosis.

[DodgyDeals]

It's true that serotonin itself , unlike LSD and Psilocin, does not cross the blood--brain barrier. However, its precursor amino acids, 5-HTP and tryptophan do, so taking them might acheieve something (which is why these are used as antidepressants).

[DodgyDeals]

I agree with the main point you're making though, I myself was prescribed fluoxetine/prozac for obessive-compulsive disorder and anxiety, but I've found psilocybe mushrooms in particular to be of greater benefit and have far less interactions with other drugs such as alcohol/caffiene, than prozac does.

[mellowmushgrapetripp]

4-phosphoryloxy-N,N-dimethyltr­yptamine and 4-hydroxy-N,N-dimethyltryptami­ne contain ---R & ----NH2 so i guess it is an amino acid, crossed my mind really good debate on this sort of thing, also i wanna ask you something my buddy who also studying this said an enzyme inhibitor L-Amino Acid Decarboxylase (different than an MAOI)This enzyme inhibitor would allow the Serotonin to cross the blood-brain barrier unaffected? if not what inhibitor would? anyways thanks 4 the clear keep up the good work

[moe4roar]

to mellowmushgrapetripp:

your obviously a smart person, but have you ever heard of sentences and full stops? It's hard to follow your arguement when you have a massive paragraph as just one long string of text.

[peacemtn]

Good job save the depressed people!!

[floydianworld]

What you're saying makes a fair degree of sense... And hey, there's nothing wrong with a hypothesis... People should always be open to consider new explanations and solutions, especially since the current treatment of depression with SSRIs is problematic to say the least.

[bosino1983]

Please please, pleeease!

[fun69stein]

depression is a brain tortured by excessive masturbation.

Unloved children seek warmth and love in own endorphines and become depressed adults.

That'a the whole truth.

It's very hard to get rid of that addiction and it's very hard to recover from depression.

since medical business says that masturbation is ok depression is becoming a social disaster.

[3DMarkSeries]

=D =D =D

[xav13r8710]

how do you figure that? all i have to say is wtf but if you have a better explination then please inform me...

[fun69stein]

you may exprience that truth.

It takes 6 weeks for the brain to regenerate and recover from depression.

No drugs needed - just no sex of any kind.

Depression as a social disaster is a result of promoting masturbation as healthy.

Drug companies make 250bln$ a year on masturbation - so it's healhy for them.

[retortme]

Get your hand off it mate!!!!

[blessluna]

whe i was teen prozac made me feel dissconnected from the world/emotions so i started cuting myself to see if i could still feel i didnt ever feel suicidal but homacidel

tord the people who put me on the shit singled me out i was different goth melancholy an artist creative wore all black they tryed to strip my identity and make me a stranger to myself i was content an at peace b4 the meds not depressed. indifferent maybe or callious even i valued nature & beauty more then people

[3DMarkSeries]

I have no idé what I am suppuse to say about this... =/

I´m on SSRI "Cipralex"

[enishicz28]

umm for all those people saying psychiatry is fake and SSRIs correct a chemical imbalance, it's simply not true, SSRIs increase seratonin, but that's not what fixes depressioin, the result of increased seratonin causes epigenetic changes which upregulates BDNF (Brain derived neurotropic factors) and promotes growth in certain areas of the hippocampus that provide feedback inhibition to the HPA axis, which is responsible for the feeling of depression and anxiety.

[molyneux1000]

Just as a matter of interest, what test results did they give you or your brother that showed he had a chemical imbalance.

[hajarc]

The chemical imbalance is a myth.

Many psychs admit that noone knows what the "right" balance is.

Psychiatry is fraud and pharmas do whatever to make money.

[3DMarkSeries]

No, you have it all wrong...

[ivanago]

explain

[3DMarkSeries]

Zoloft sucks...

[bkelaries]

I think that if one is taking medication for any kind of mental issue then some sort of therapy has to go in tandem with it-otherwise its like putting a plaster on a gaping wound,its not solving the whole problem.People have very different reactions to meds,what works for one person won't work for someone else. I've been on Lithium and Prozac for a couple years and I've had no side effects except a bit of nausea and some tiredness. I'm also in therapy and the combination is really working.

[oxidenitric]

hello guys, everything that is said here is very interesting, but please what are the names of the 2nd generation SSRI's?

thanks, a quick hello from france.

[baypelham]

how about the weight gain on lexapro paxil and prozac

[dopplerdog2000]

Chemical balances do exist, but there is more than one way to manipulate a synapse. There is research in getting more serotonin in they body through pre-synaptic agonization rather than reuptake inhibition.

[deptsd]

Depression is horrible but these drugs are fucking dangerous! They aren't a cure, people are just stoned. Research it and find out the truth about the side effects.

[aeronuk1]

I took a course of them and felt brilliant, I didn't have any side affects at all, nor did I feel stoned, but the second time I took them they had no affect at all.

[deptsd]

you felt brilliant because you were stoned dude. drugs are drugs. these psychotropic drugs come from the same family as speed and cocaine.ever heard of dex amphetamine? amphetamines are speed, right! ever wondered why they cqall it kiddie cocaine? the kids are so stoned they just seem to chill out. then they freak out and go psycho.

[aeronuk1]

No, your wrong! Iv'e been stoned and I know the differance! The feeling I got from prozac was brilliant, but it felt totally natural. Not like being stoned at all, just like feeling really happy, but for no reason at all

[mdma4life]

No, doctors = total frauds

If you actually contact your countries occupational health board they will provide you with a list of all the Psychiatrists in your area AS WELL AS A DESCRIPTION OF THEIR ANNUAL PERFORMANCE REVIEWS. Aka, if a psychiatrist is a fraus, you'll know it, pick one of the good ones.

[emilydonegan3]

Prozac has been working for me...OMG I can't believe I just posted this!

[originpax]

That's good to hear Emily. Good luck.

[mdma4life]

Nothing to be ashamed of, depression is a disease just like any other, and those that say it isn't ... don't suffer from it, thus they cannot know :)

I'm very glad you are having success, it can be a challenge to find the right treatment.

I would suggest, if you get the oppurtunity, to look into second generation SSRI's, Prozac is pretty bad for you, and i'm not even sure why its still being prescribed. Good Luck

[DefeatADDnow]

it may be working for you now but it will eventually deplete you of serotonin and cause other problems.tryptophan makes more serotonin naturally.

[mdma4life]

SSRIs do have a very valuable place in medical treatment, but only to those that actually suffer a condition of depleted serotonin, its bad rep comes primarily from stupid doctors who think they are psychiatrists and throw it out there like its candy. SSRIs are only to be used by those that suffer from a disease that has been diagnosed by a psychiatrist.

[originpax]

Yes and no. A lot of people would be too scared to go to a psychiatrist because of the societal stigma.

[mdma4life]

Anyone that suffers from true clinical uni/bipolar depression is already having serious troubles integrating themselves into society. If someone truly suffers from depression they'll know exactly what I mean (for the rest of you, depression cannot be described by words alone, unless you've suffered it, you've no clue what it is). For those people, if they really want to get better they need to see a Psychiatrist, fuck society and its labels.

[originpax]

I didn't say societal stigmas weren't idiotic, but they exist man.

[sleestack808]

so true. They see it as week minded or crazy. Its kinda sad.

[mdma4life]

Perhaps, but the 2nd generation SSRIs ARE much safer. I'm not saying they are the SAFEST, or that they should be taken by everyone who feels they are sad, i'm just saying prozac is widely known to be one of the harshest SSRIs out there. In fact I don't even know why its still prescribed. I'm sorry you've had bad experience with it, its not right.

[MowSow]

OK .. the yellow molecules are serotonin floating at the synapses and the red things blinking on the synapse surface are the receptors (5HT) being triggered by serotonin .. the big molecule in the second part is Prozac, it comes and blocks the channel where the serotonin is being reuptaken by the cell, which causes the level of serotonin to stay elevated.

[nikko801]

Can someone explain what is happening in simple words for who doesn't know too much of biology and biochemistry? why serotonine should be stay high and what prozac really do?

[originpax]

Nikko801, serotonin is a neurotransmitter, that is, it sends messages between braincells. It is thought that serotonin plays a role in regulating mood.

Low levels of serotonin are associated with depression and anxiety, SSRI's cause the body's own serotonin to work harder.

[KnightFitzpatrick]

Thanks, good for med professionals though

[delgamx2]

Good animation

[boredperson81]

i could not understand anything

[lairdpowell]

I bet you say that a lot LMAO

[pizful]

good animation. tnx for posting.

---

be careful. it helps some people, does nothing for others, and damage and kill the rest.

research.

[psychpatient101]

SSRI's Affect countless brain functions and processes other than serotonin. The drugs are not to selective in reality. If you read the list of side effects you will see how true this statement is. The brain is so complex, it irresponsable to be giving people mind altering drugs.

[mdma4life]

No publication i've ever read has shown SSRIs to bind to nothing but serotonin reuptake complexes, or transient serotonin reuptake scaffolds ... you should read some science publications

[psychpatient101]

Yeah your right forget the (PROZAC INDUCED MANIA) These drugs just make you feel happy :)

Just forget the (INSOMINA) no big deal if you can't sleep :) Forget the (WEIGHTGAIN) great for the self esteem :) Your right I just need to read some science publications and ignore these trivial things. PEACE AND LOVE :)

[mdma4life]

All these side affects are directly related to serotonin regulation, so yeah .. what was the point of you're post? SSRIs only bind serotonin receptors, you just proved it .. thanks

[psychpatient101]

YW :) MY point-  For future victims of Prozac :) Hate for someone to take prozac, then get fooled into believeing they are bipolar.

[mdma4life]

prozac is also a first generation SSRI, the other ones that have come out are much safer, even the drug companies have admitted it :)

[psychpatient101]

Hmm.... maybe they say that because they want to sell there new drugs that have a patent? :)

[originpax]

It is possible for SSRI's to trigger or exacerbate mania, but it's very rare. Like every drug, they can have side effects.

I would suggest that manic reactions occur in people with existing bi-polar disorder, most people only tell their doctors about being depressed, and don't recognize manic episodes for what they are.

[DefeatADDnow]

finally,someone who understands how corrupt the drug companies are

[DefeatADDnow]

psychiatry is complete bullshit.Innate chemical imbalances do not exist.However,chemical imbalances with causes do exist.Some causes are hypthyroidism,adrenal exhaustion,tryptophan/vitamin d deficiency,candida,and heavy metal toxicity.F

[DefeatADDnow]

iron,Nadh,vitamin D,BH4 make more dopamine through tyrosine hydroxylase.Their are a million mechanisms like this that can be addressed to cure the chemical imbalance.The drug companies know this.

[twoallbeefpatties]

You will never know until you actually have to deal with a problem that you can't correct yourself and you need medication.

[pacskin]

true that

[DefeatADDnow]

Umm sorry you're wrong.I dont doubt that drugs bring short term relief for some but they will make the chemical imbalance worse in the long run.

[RustyDK]

isnt the whole point of anti-depressant drugs merely to help the person get to the level they were at prior to having depression. I used to be on anti-depressants and was told that simply taking the drugs on their own would do basically nothing...I had to make a conscious effort to make sure i was making changes in my life.

again i guess it would depend on how one's depression is brought about...situational/acute...

[DefeatADDnow]

It's not that you can't cure it,it's that you have never come across a competent integrative physician who knows how to cure it.Btw I speak from experience.

[pose716]

cool this could help my project.thanks!