Pathogen Recognition in a Macrophage Cell

[mssamoora1]

like



[TamiJane]

I like the music.

[JayInk11]

what im wondring is what will occor after the prosses

[coldfyre18]

Science porn?

[deefromott]

these animations are really pointless. "This is a ball" "This is also a ball"

[Nostyc]

@deefromott - these animations are showing processes that you obviously don't understand and have no need for ... how you ended up commenting on something that does matter with a comment that truly doesn't is quite interesting ...

[MeatfortoeatALT]

@deefromott You are clearly WAY in over your head.

[JuglarEuskaldun]

New bizarre 3D hentai.

[TwinkleLT]

what happens afterwards? -_-

[LonelyaLavonaj830]

l0l_ãNÿ_gÜYs_wÅÑt_tô_chÅt_wÏth­_mé

[YouDuck2345]

@LonelyaLavonaj830 Ñô.

[castrofredy]

what's the name of the song

[Skrib]

my wife thought i was watching soft porn ..cmon ..

[sumayash]

can u show us in more details? and 4 the size o virus it doesnt make sense???????

[mtorres004]

Turn off music & get commentator

[quiquey]

esta mal este video los macrofagos no tienen receptores especificos para patogenos sin previa opsonizacion mediante ig o complemento para poder reconocerlos

[rodriguezo12345]

cell porn

[manlykblaze]

whats the name of the tuuuune need it badly

[notafraidtouseit]

hate the music everything else is great

[rotateaxis]

this music comes when you REALLY feel wierd.....

[seanmPWH]

It's so weird how those macrophages make that ambient techno music .

[medicappharmacy]

Quite interestingly presented.

[Kirstyloo2]

Columbia - The receptors on the macrophage can't be IgG because the affinity of IgG (an antibody) aren't high enough to bind individual antibodies. Antibodies bind the pathogen first. After that the antibodies Fc regions are bound by Fc receptors on the macrophage. I do agree. I couldn't tell what type of receptor is mediating this event.

[Zeanu]

Macrophages kick ass!

[PhenomenalConspiracy]

Glad i dont have AIDS and thank god for macrophages :D

[ColumbiaPH]

Cool animation but it's not correct. Antigens don't bind in the middle of the "Y" region between the two heavy chains of the antibody. There are actually 2 binding sites at the end of each each tip of the "Y" between the variable regions of the light and heavy chains. If you are studying immunology, don't take this video as correct if you are trying to understand how it really binds.

[sonyaNBA]

@ColumbiaPH but these aren't antibodies... theres no tcr or antibody on macrophages

[ColumbiaPH]

@sonyaNBA I stand corrected after finishing immuno - I think they could be TLR's or PRRs (Toll-like receptors and Pattern recognition receptors) on the macrophage binding to PAMP's (Pathogen-Associated Molecular Patterns) on the Pathogen. What do you think?

[sonyaNBA]

@ColumbiaPH yeah, that's what I'm assuming... because macrophages have PRR's (TLR) and they have class 2 and maybe class 1 MHC so they can act as antigen presenting cells... Then once the pathogen binds, they can upregulate their class 2 expression so T helper cells can recognize etc...

hope thats right because i have my final tomorrow morning lol

[ColumbiaPH]

@sonyaNBA could possibly be MHC class II, because they are on APC's, but they usually are associated with presenting the antigen after they are engulfed and processed. before phagocytosis direct recognition is most likely with the TLR's. good luck on the exam - 2nd term SOM?

[almacocoa98]

Everytime I get sick I'll remember this rolf

[janitarjanitar]

that must be a HUGE pathogen

[ironnica]

wheres the engulfing :/

[smartypantz69]

@ironnica thats he whole point probs of the video to show wat happens wen ur body loses for a bit lol

[ironnica]

@smartypantz69 lol, it aint losing. i cant see any sense in that comment haha.

brill video, but needed the other stages

[DarkHero187]

shit like this shouldnt exist in nature at all all viruses and cureable by yoru own immune system. if u want the truth behind the gov go to infowarsDOTcom

[Porganised]

That was a promising video that delivered poorly

[SuperNick311]

what is the cell doing

[iSkyttens]

Haha I can imagine this music playing when my immunitysystem is fighting off pathogens in my body in this exact moment! rofl

[bourbonstmc]

Great animation. Somebody pay these people for it, and then hire some writers and a narrator. :)

[imanarutoaddict49]

this is the pathogen.. he is being played by bob today

[middimar]

i bet it was the oportunistic S. aureus in dermis lol

[cerm90]

do the macrophages have those kinds of receptors as in video or maybe different form?

[alioshja]

different form, take a look to TLRs on the web or at the PDB (protein data base)

[juanpablofx]

hey hey hey! I don't want my macrophages to be making friends with generic pathogens. Yes, I'm racist against generic pathogens and I'm not afraid to say it.

[achillesian]

@juanpablofx microbiology troll oh no! lol

[nabilix]

@juanpablofx what did they do to make you say such a thing. the struggle to survive just how humans do ... they do no more harm to nature than we do. sometimes they deserve more respect and rights

will humans colonise this planet entirly untill our race sucks the last drop of life there is on this planet?

fight for pathogene's rights ! humans should devolve !!!

[Twizler1000]

stop bad commplements this is asome

[chinkahbell]

They should make one where it gets endocytosed and degraded in the phagolysosome! That would be awesome....

[theXdude69]

Lol u seem as if u know what ur doin so here's a thing

i need to know what happens when Pathogens enter the body? in chronological order pls :D

[B00113560]

oooooooooooo can any1 help me with immunology or medical micro?

[26002664]

Sure, what do you want to know?

[B00113560]

lol its kool i did my exam fingers crossed, if any1 can help me understand proteins in depth that would be excellent!

[U91H3D]

u can call us science freaks all u want but if u had no macrophages u would be dead

[tasaraha2009]

the aliens hav elanded, cool vid

[Btelgeuse]

Nice!

[hypergod2000]

WTF? UR ALL SCIENCE CREEPS!

[waverider]

ya, us all science creeps are saving lives - including yours.

[kagomegirl128]

So thats the HIV viurs hey?

[Kirstyloo2]

@kagomegirl128 - No. This is most likely bacteria of fungi.

[The4one4you4slept4on]

is hiv man made? if not then where did it come from

[farahfar]

HIV is not man made, Simply put HIV prob originated from primates, their immune system can handle HIV, at some point in time that HIV virus infected a human, since it can be inur system for several months without symptoms it can be easily passed from one person to another. The problem is that human immune systems can't get rid of the virus.

[kastelruther]

not exactly true... in some african primates like chimps there is a common virus called Simian immunodeficiency virus (SIV). It does not kill the animal. But sometimes humans hunt other primates for bushmeat and some of them infected themselves with SIV. Furthermore the virus mutated( it's easy for viruses to mutate and become a new virus) and adopted to the human environment and is now known as HIV

[Generic1987]

i love how it magically lines up seemingly of its own volition

[westerj]

As if it had free will.. I know... these things are very tiny things and they have intent. Am as much of a scientist as anyone, but how does such a thing have -intent-?

[pizzintea]

It does not, it is a series of chemical reactions. So maybe you could say the same about us.

[Masteroiece]

I have a question, If immune system has no problem making antibodies for microbial pathogen but cannot make antibodies for viral infections where is the problem???

[farahfar]

To answer you question, microbial infection happen on the outside of cell, The immune responce to this is producing neuralizing antibodies that can stop the the pathogen from causing damage. VIRAL infection happen INSIDE the cell. therefore an antibody immune responce is uneffective. The correct immune responce to this type of infection is to produce more cells, specifally Cyotoxic T cells, which kills infected cells. Antibodies cant enter cells and do work.

[Masteroiece]

very interesting... can anti-bodies also bind viruses circulating in the blood?

[heresthadude1080]

Exactly

[gavincurtis]

Virus has to enter a cell and alter internal machinery at which the affected cell sends out a "distress call".

T cells then seek out the infected cells and destroy them.

We are made up of nanomachines waging war and also looking out for each other!

[bvns1234]

i dont know much about medicine but i loved your videos and the music on video Pathogen Recognition is great!!! does it have a name?

[theotzaridis]

The antigens have certain epitops, which can be specifically recognised by macrophages.

[medobll]

what is the name of the receptors on the surface of the cells, ... arn't they called Antigens ??????

[VHAF001]

they have many names... wich bring together all of it is Patogen Asociated Molecular Pattern Receptors (PAMPR) wich includes Manose receptors, C-type Lectines receptors, unmetilated DNA, also is so important make mention of the Tolll- like receptors.. at least 10 types, which can recognize the PAMPs.... for the common patogen... each molecule sharing by the uorganism has a specific receptor molecule in the innate responce cells

[polarbearnolan]

nice music!!!!!!!!!!!!!!!!

[Bhivizy]

ok, somebody please correct me if im wrong, but after what happens in the vid,

the macrophage will release oxidants and bleach to kill and eat the pathogen, which than it will present a piece of the pathogen on an MHC Class-2 mollecule to a T-helper (CD-4) cell... The T-cell will than release specific cytokines (IL-2, and IL-5 i think) to activate more macrophages and also B-cell maturation and proliferation for antibody production.

[jffryfnt]

The macrophage recognizes the pathogen through it's toll-like receptors. Then, the macrophage will endocytose the bacteria into it's phagosome, fuse with the lysosome, and kill the pathogen through nitric oxide production. However, macrophages are not professional antigen presentation cells like dendritic cells. If the pathogen can't be cleared with an innate response, an adaptive response is necessary where MHC class II and bacterial peptides are presented to T helper cells.

[jffryfnt]

The dendritic cell, in an attempt to initiate an adaptive response, will upregulate MHC class II, release cytokines like IL2, IL12, possibly IL23, IL27, etc. (intracellular pathogens or Th1 responses). Th2 responses involve IL5, IL7, IL13, etc. (extracellular). It's a very complex mix. Depending on the T-cell polarization will also dictate the T helper response to B-cells in creating antibodies.

[homeostasis4me]

yes, yes....immunology is cool, no?

[VHAF001]

good answer, but the oxidative burst occurs when the pathogen cannot be "eaten" by the macrophages... or D cells ... o B cells (minor)

[jffryfnt]

"but the oxidative burst occurs when the pathogen cannot be "eaten" by the macrophages... or D cells ... o B cells (minor)"

Say what? Are you saying the 'oxidative burst' occurs extracellularly? What is a 'D' cell? Or do you mean, T cell?

[firehawk369]

i like ur videos nucleusanimation.their interesting....im interested in da human body aswell.

[saysaygirl247]

so pathogens comes out when you sneeze and antibodies trys to destroy them?

and perfect animation view, really awesome.

[Bhivizy]

well... antibodies are more like bright red flags that stick to a specific pathogen... now, the cells that normally do all the killing, can easily track down the "flagged" pathogen and destroy it.

[Welssin]

excellent animations ...

[katiekat724]

fantastic!!!

[cdyeager]

This biology animation demonstrates pathogen recognition very well. I'm impressed by all your 3-D animations, Nucleus Medical Art.

[D4vy87]

So those cell surface receptors are TLR's? and the green ligands are the PAMP's? would've been useful 3 days ago, bugger! although a signalling pathway would've been cool aswell! get on it!

[WigglySquid]

The portrayal of the cell surface as a landscape really brings this 3D biological animation to life.

[smithadaniel]

its awesome

[mcollin14]

An awesome biology animation.

[ACEgenetics]

Excellent medical and scientific 3D animation of pathogen recognition Nucleus Medical Art!

[bean602]

This 3D animation is such an effective visual interpretation of pathogen recognition.

[PhillipsStudios]

I love the dynamic surface in this biological animation. It really makes this 3D animation effective.

[nscragg5]

LOVE IT!!!!