What are Chaperones and How do They Work? Pande Group

[Njzavitz]

@ilhsfm Did you realize that you used an unnecessary description infront of the word "gospel?" Durrr Hurr

[Designmimetics]

He was giving accurate information and sounding intelligent until the 41-46 sec point. Blind Nature can't make machinery inside the cell. Only Intelligence can do that.

[IloveYOUviruses]

@Designmimetics No, nature-did-it, I'll explain your mistake: in order to solve the missfolding problem, nature evolved chaperones from cells that suffered the missfolding problem, you can't deny that, it's evident.

[ilhsfm]

@Designmimetics leave your religious gospel for church, not for a biology video.

[shoemoodoshaloo]

PS2 IS WEAK NOW!

[roller237]

Thanks for this. Did me well for my biology class

[giglisawblade]

wow nature sure is smart

[planetinvader]

Could you make another video with an advance lecture and disregarding the basics?

[Soulnik]

A variety of age-related diseases, such as neurodegenerative conditions are associated with aggregation of proteins due to improper folding.

Conformational diseases associated with improperly folded proteins include cancer, cystic fibrosis, emphysema, liver disease, and even chronic pain (opioid receptors misfolded in the endoplasmic reticulum). Protein aggregation may also cause cataracts.

[Soulnik]

A variety of age-related diseases, such as neurodegenerative conditions are associated with aggregation of proteins due to improper folding.

Conformational diseases associated with improperly

folded proteins include cancer, cystic fibrosis, emphysema, liver disease, and even chronic pain.

[Soulnik]

An important class of natural chemical chaperones that help stabilize the proper folding conformation of proteins are the osmolytes. These include betaine, inositol, taurine, glycerophosphocholine, choline, and creatine. I have been taking a cocktail of osmolytes to help maintain my proteins in a properly folded state. The quality control of protein folding is very important to health and longevity.

[Soulnik]

An important class of natural chemical chaperones that help stabilize the proper folding conformation of proteins are the osmolytes. These include betaine, inositol, taurine, glycerophosphocholine, choline, and creatine. I have been taking a cocktail of osmolytes to help maintain my proteins in a properly folded state. The quality control of protein folding is very important to health and longevity.

[varfunc]

does anybody know where the caps come from and how they know to "close the lid" on these heat shock chaperones and flex/coordinate with the chaperone to accomodate the refold attempt?

[lucifervilleq8]

i got a project on extracellular chaperones!!!!

[sweetjoesus]

Del, you're both scientist and genius! You do me proud, old friend!

[CoolPhotos]

GEEKS for a CURE Team ID #84451 Join Us GEEKS!

[CastleBomb44]

Interesting, Nice ps2 shirt I wonder where you got that shirt. Too bad I have been using my ps3 to do my folding@home.

[dsfgdsfg324]

What's with the playstation 2 shirt?

Hope you're getting some results out of the projejt, have all my computers running F@H.

[nitro734]

Found this interesting, you guys should make more of these videos!