B Lymphocytes (B cells)

[10000wingsformarie]

what is the next video in the sequence?

[qais84able]

First thank you for this wonderful illustration. I have some questions.

1. Where does these processes take place? I mean do all of them happen in the bone marrow? plasma or lymphoid organs?

2. U mentioned that B-cells can recognize an antigen, but can they activate themselves spontaneously?? or they need helper t-cells as well??

3. what's about the role of b cell receptors (BCR) in recognizing antigen?

4. How does hypermutation play a role in B-cell activation?

Thank you for your time & help

[milayaledi]

I'm the freshman of medical college student and currently learning about this.

And you're far better than any lecturer and any books that i've read in explaining these stuff.

You really help a lot!

Thank you :)

[mariposaespanola]

Thank you!!!!!!!

[dindanio1]

3 people wished they had watched this video before the exams lol.

[medfreak1990]

I love it, was once so confused about all these innate, humoral immunity, all sorted in my head now!!!! FANTASTIC!!!

[soumyasayujya]

m in 12th.....and all this s really helping me understand and appreciate my body more than ever.......!!!!!..........i shd hav started being a visual learner much be4...cos this let me a lot more in leeeeessss time!!! :)

[shreyakothari1991]

great video!



[Mjhond]

I am very happy to see the vidoe after you give this Overview of B cells (B lymphocytes) and how they are activated and produce antibodies

[Ondelendo]

I Love The Video It Can Increase My Knowledge Overview of B cells (B lymphocytes) and how they are activated and produce antibodies

[anakmudajaman]

Steady I Really Like This Video Overview of B cells (B lymphocytes) and how they are activated and produce antibodies

[bebeheuy]

Good, I like that you share this video, I wish success always Overview of B cells (B lymphocytes) and how they are activated and produce antibodies

[imegatrone]

Nice Video That You Share , So Very Nice Thanks You Overview of B cells (B lymphocytes) and how they are activated and produce antibodies

[bundawartini]

Your Video Is Very Useful Sharing Overview of B cells (B lymphocytes) and how they are activated and produc

[3abr7man]

3 engineers watched this video :D

[Grkgermn333]

@3abr7man Why do engineers hate Biology? :o

[Arjun072]

thanks a million sir this video helped me a lot

[chiragrising]

Im a medical student and you teach physiology much better than my dumbfuck oversmart teachers who complicate things just to show their SMART.. thnku so much and i wish we had more teachers like u specially in the medical field ...keep rocking :D

[flogurl9]

I don't know why professors have to be so sneaky by omitting info and assuming that we'll somehow figure it out with the hundreds of notes that we have to study. You sound more passionate about what you're teaching than any professor I've known in medicine. Thank you.

[swtkissez40]

be my boyfriend!

[postmortemarg]

this is so fcking gooooood!

[LittleE6]

Wow! this helps alot!

[LittleE6]

The DNA is shuffling!

[tennis1412]

learned better than in my microbio class thanks!

[m00035]

thank yoou SO muchhhhhhhhhhhhhhhhhhhhhhh

[OriginalxS]

In french please ? lool .. :(

[zackboomer]

@10:10 B cell and arrow face

[Grobian90]

if we produce so much aantibodies for every pathogen wont we get full? O.o do we have space for everything?

[TheNeverborn]

@Grobian90 Once the pathogen goes away, the effector cells (aka plasma cells) stop producing antibodies and die. So we're usually only actively producing antibodies towards current infections.

[just0jackable]

hahaha thumbs up if u see a guy wearing glasses at 10:08

[cbwickstrom]

I love you.

[petroc93]

Good video, but there are actually about 100,000 antigen receptors on the surface of a mature B lymphocyte, not 10,000

[Wayneritsema]

Didn't know God makes youtube videos.

[themarchiones]

you are a wonderful teacher, thank you!! I just was not understanding adaptive immunity until now!

[MrsMeeks05]

I swear you are a life saver!! My anatomy grade is up because of you!!!!!!!

[socratousd]

THANKS MEN HEEPPING TEACHING US I WISH TO BE MY PROFESSOR

[figuresk8erbabe]

Thank you SO much. I wish you were teaching my class. You're like "Bob Ross meets Biology." .... happy little cell....

[lublin54]

world need more teaches like you.Thank you.

[kimjoannah]

you are AMAZING.

[Giesinger07]

@aloutfy720 Thank you so much, that clears it up a lot. How many AAs are usually in an antigen if there are only 6-8 in an epitope?

[Giesinger07]

what is the difference between an antigen and an epitope?

[aloutfy720]

@Giesinger07 an epitope is a small part of the antigen that binds to the antigen binding site. It is about 6-8 amino acids in length.

[shellymclaughlin]

Thank you so much =)

[GuppyPal]

I'm taking immunology and my professor is boring as all hell. Thank you for explaining things even though I'm sure this was WAY outside your field of study.

[MoeWoW0]

How do you simplify things so well?

[tsf2ba]

amazing teacher...all medical school teachers should take training from u.

[nikitapinja]

its amazing!!!

[kittyshh]

i just love ur all videos...i m having immunology this semester..n u r angel 4 me to help me out wid these videos..really ossom..great job...

[m33taphor]

i now have one teacher for all my classes. that teacher is you!

[ThugRandles]

SO GOOD! Don't ever stop making these videos man, you rock! Thanks :D

[crackowacko87]

A page-turner, but in this case, a video-clicker

[missmercy05]

thank yu thank yu thank yu!!!! my teacher is a BORE and these videos actually keep me up when I'm studying at 12:30 in the morning...PLEASE KEEP THEM COMING!!!

[MsSreyDa]

You are the best. Much better in illitrating and explaning this than both of my college professors. :)

[mrscambuster1001]

Reasonable good job to explain generation of diversity while sidestepping recombinase, VDJC regions, and class switch...saving that material for another video perhaps?

It would be a good place to provide the ABCs of immunogenetics and immunochemistry to present a more comprehensive overview, but it might amount to overload to first time learners...

[JustBeganViolin]

hahah i think he loves playing with that cool writing thingy he is using.. i dont know what it is called :p

[Agus1912E]

What is really really REALLY interesting !! hahaha he's so passionate about this.

[lolipopcupcake]

Amazing!

[MegaJet23]

everyday im shuffling ...yours truly b-cell DNA

[nessie760]

Hahaha, @2:04 - @2:08 . REALLY really really really :P

[FocusWLN]

thankyou so much! I recognize your voice from somewhere? Better lesson through squiggly lines and a voice than i've had in a long time!

[meallme1]

legend, greatest explanation

[Basmor]

@atph120890 When you're infected by a virus your immune system produce tons of memory cells (in fact, it is the exact B cell which is copying itself) There is a fixed number of clones. They then just do nothing. Your immune system fights the infection and you're safe but the clones are still waiting. As he says, maybe 10 years later you'll be infected by the same virus. Then, the phenomenon will repeat for EACH memory cells! (that gives us a lot of antibodies, it is btw how vaccination works :))

[hotteen1000]

what is the app or program he using? I want to use it in the university, plugging the laptop with data show.

[atph120890]

ahm... do memory cell multiply as well?

and after multiplying produce Antibodies??

[karimshaheda]

Love the accent, makes Biology all the more exciting!

Thanks, helped me loads.

[earlgraymistress]

Thank You so much! I enjoyed this. You make it so much easier to understand.

[igopking]

@noclassatall Idiot, everything I said is right

[hansemand]

Extremely helpfull for my nurse exam. Among the best educational videos i found on YT.

[studentfitness]

So helpful! Thank you very much England

[sejungcecilia]

this is very helpful

[happyhaunter2]

Thank you! Helped having a video to go along with my studying..makes it that much more memorable! Im glad Im not the only one that stutters at times at the names!

[thehobbity]

the best explanation, thank you,keep the vids coming.

[dancinga1one]

I skipped all the class of immunology this semester.. because I dont wanna read the boring textbook. But after I have watched your inspiring videos, i get back my interest in it.

IM GONNA GET AN A IN THE UPSOMING EXAM :)

Thank you so much!

[ukprincess100]

how can someone possibly know everything about everything!!! you are amazing

[igopking]

@noclassatall Yes, antibodies in your blood stream suggests that it is working, and fighting an infection. With HIV, the virus mutates so fast that your body keeps trying to produce the right antibody, but by the time the antibody is made in sufficient quantities, its "outdated" so to speak, because the HIV has mutated its epitope (antibody connection site). This will result in a lot of antibodies in the blood stream that can't help you because the HIV is mutating so fast.

[Pangjunmin]

I love that he's using a black background, he knows most of us are staying up late at night and the white background would burn our eyes O_O

[PacificSurgeNJ]

these are great vids, but i wish he would use textbook terms like clonal deletion instead of "self" responding combination

[review424]

I'm studying immune system for the MCAT, and I thought I'd make a notesheet for quick review.

tinyurl

.com

/review424-2

Sorry for the messy url. I don't think Khan likes them!

[deyulalu]

THANK YOU !!!! veerrryyy helpful :D

[jvlrjhalex]

This is such a great video! i missed 3 days of school (and in a level studies, that's a hell of a lot of work) and this is great to understand the basics that i have missed. thankyou

[cpfcfan124]

Well hopefully this time ill get more marks than just the one i got for my name :)

[1MauCha]

good bro.

[yuliyalovesali]

Bless your soul. I love your videos. I feel so much better about immunity. Thank you so much!!!

[Medicalmarcl]

good intentions but too few information..

..i don't find it useful..

[jessieleighwinokur]

Ahhh oh my god thank you for this Immunology lesson. You make this so interesting and easy to understand. I'm so happy to find things like this on YouTube that make doing a B.Sc so much easier.

[sharedivinelove]

U teach very interestingly.. Thanks

[ratboyds]

Fantastic way to learn!

[iasi2011]

You are doing grt8 job. Thanks a lots :)

[07837225519]

Amazing!!! better than my lecturer's. You have an amazing way of making the information sink in! Better than any book! I love your videos please keep them coming! They help me with my degree revision!!

[hummer4700]

as far as i'm concerned i think that viruses can't be fagocytosed, because they're too small. this process happens only with bacteries.

[koliber231]

oh god 2000 antibodies a second thats amazing! ^.^

[abodxox]

thank you =D

[rigil1]

thank you....

[127miles]

is this what you learn in biology or medical school

[MWarren221994]

@127miles I'm in the grade eleven biology and we are currently learning this.

[MrAloha1991]

Very veeery nice video. Thank you for the opload, it helped a lot. : )

[mikey0892]

how does he know everything! D:

[olutunu4]

@mikey0892 i know riiite! well, thank God he does bcos he does very well at teaching :)

[cbouhlel]

This is amazing. THANK YOU!

[davidh2011]

very clear and concise! Thanks a bunch.

[enelijit]

great videos,i wish u put numbers on your videos it might make it easier to know which one is next

[missmelis45]

Great vids! I thought that lymphocytes are from lymphatic tissue versus bone marrow (which are myeloid stem cells vs lymphoid stem cells)?

[missmelis45]

Great vids! I thought that lymphocytes from lymphatic tissue versus bone marrow (which are myeloid stem cells vs lymphoid stem cells)?

[04Genji]

superb.....

[tomsterst]

After every lesson with my teacher I watch one of your videos on the particular topic and learn twice as much. XD thank you.

[invisibletheif]

medical students of the uk salute you

[judyshin1220]

Thanks so much, this helped a lot with studying for my pathophys. test tomorrow!

[jinaje]

Thanks alot, this was really helpful!

[nireshnr]

thank u so much for the video

[junglepunk13]

that's capital mate!

[vivienne135]

my gooodness this is like the best video in regards to explaining humoral mediated response....:)

[gowjo18]

great lectures. You remind me of jeff goldblum a little XD

[soninikul]

Thank you.. this lesson are very much informative

[JJboy1992]

These Bio videos have saved my HSC! Thankyou!

[wusteffi]

should the antibodies and the membrane-bound "antibody" or receptor (BCR?) be the same color, since they're coming from the same original B cell that was activated by the same antigen? Thanks.

[geminiflux0]

Thank you for this wonderful presentation.

i am wondering about the recognition receptor proteins on the B-cells and helper T-cells.

lessons on immune system often begin with a B-cell receptor proteins recognizing the antigen/foreign particle. But how did that receptor protein get there? You mentioned there are 10^10 possible combinations. So is it just by chance that there will be a receptor protein on some of your B-cells to recognize every kind of antigen out there?

[noh4241]

my Med school should hire you...

[adthomas218]

Thank you thank you thank you! I was getting really annoyed with not thoroughly understanding the entire concept by reading my text book....you make it interesting!! :) Thanks again!

[MrMsAttitude]

You are so good Professor - thankyou so much !

[chocolat0428]

I love this raw lecture style. Too beautiful narrating makes me sleepy.

[MayaCreatesChaos]

these videos make studying so much less of an effort.

lovee

[mightbleed]

Aren't memory cells T cells?

[Lassie6432]

no...t-cells stimulate b-lymphocyte...

[1006Will]

@mightbleed no, there are effector and memory cells. Both B and T cells will later develop into either. So..

[mightbleed]

@1006Will Thanks bra. :)

[jsin101]

I haven't watched a single video of urz that didn't help me. You give lots of information without making it impossible for the simpletons to understand. Thanks a lot.

[d1u9k8e7]

thnx really good job! it helps really a lot!! :)

[bhuri02]

you are really good, i love your voice,

[IslamAndPashtu]

Salamu aly kum brother Salman khan mashallah you are doing a great job. May Allah reward you and your small little cute family. And yea brother dont give examples of your self getting infected with virus. God forbid if you get infected then who is going to teach us lolz. And a small suggestion brother if you can mention the next recommended topic in every video that would be great. JazakAllah khairan you have a great heart.

[gigawatt01]

best b cell video on the net, thank you i have an exam in 2 hours, you made it clear!

[seeschocolate123]

does anyone know the next video

[BestLuJe]

thanks :)

[benjanibenjani]

superb! succinct, concise, informative, these lectures are fantastic. you are saving my skin!!!

[kevigard]

I really enjoy how you present and explain your information, I wish you were my bio teacher

[ifyc576]

Thank you. You present the material quite nicely. You make it much more exciting than my textbook. Please keep the biology videos coming!

[markytproctor]

very true!

[AngeliaChanel]

@ifyc576 I completely agree!!!!

[hupper12345]

Thankss :) wish you were my bio teacher!!

[amiebelle]

That was so helpful!

[tigertail24]

Great Video, Thanks!

[Jerromme]

dude you are the best

[Sameer3292]

Thats not a virus !!! Thats a cyclohexane !!! :] LOL .

[danifilth3]

@Sameer3292 a virus always has the shape of a cyclohexane ;)