If you are interested in the discovery of Cisplatin, look for the entry on Barnett Rosenberg at the Michigan State Sesquicentennial Oral History Project. In the mp3 audio of part 1/3, Rosenberg describes the discovery of Cisplatin around the 24 minute mark.
This how they control people and the world- (but they are not going to tell you that) - It's a secret agenda - I think they do this in this building "Western State Property Management" (Why I'm telling you that-bec I can't fight this MAFIA) to keep everybody behaving like nice quit "ZOMBIES" that walking and hypnotize like a puppies!!!!!!!! Under ground secret movements!!!!
To me this give me a headache and ringing in my ears- If this wt t'-wnt to achieve THEN T'-GOT IT!!!!!!
thats not how it works. Pt binds, mmr proteins attempt to repair the damage and when it proves impossible they trigger apoptosis. thats why it doesnt work on cancer cells that lack mmr machinery. there is no alkylation/kink creating step.
nice animation! However I have to agree with mforrest24 that the compuond that react with DNA is the diaqua compound. Also maybe you could improve the DNA-binding step. In the video the chlorine go away and then cisplatin react with the 2 Gs. Actually the reaction is more that the nitrogen on the G attacks the Pt atom displacing the OH2 groups. But again, is a very good job
defusion or diffusion?
maridejun 3 months ago
so does cisplatin bound to DNA of "good" cells and kill them too?
jasonchuu 3 months ago
@jasonchuu
Yes! Cisplatin is one of the chemotherapeutic drug with most severe side effects!
Michaelingolfhansen 2 months ago
If you are interested in the discovery of Cisplatin, look for the entry on Barnett Rosenberg at the Michigan State Sesquicentennial Oral History Project. In the mp3 audio of part 1/3, Rosenberg describes the discovery of Cisplatin around the 24 minute mark.
Similie 7 months ago
Cool this cleared up a few missing pieces of information for my chem study lol. But doesn't the cisplatin become hydrolysed upon entering the cell?
mattymuck 8 months ago
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This how they control people and the world- (but they are not going to tell you that) - It's a secret agenda - I think they do this in this building "Western State Property Management" (Why I'm telling you that-bec I can't fight this MAFIA) to keep everybody behaving like nice quit "ZOMBIES" that walking and hypnotize like a puppies!!!!!!!! Under ground secret movements!!!!
To me this give me a headache and ringing in my ears- If this wt t'-wnt to achieve THEN T'-GOT IT!!!!!!
src438 9 months ago
Actually cisplatin gets aquated which is where the charge on the Pt comes from, which is what enables it to bind to DNA
sa2uklost 9 months ago
"Wild Cat" is the most ridiculous song for this movie possible.
drewfer5 11 months ago 7
this is very creative animation
may i inquire about recent advances regarding nanoparticles of cisplatin
shahinazmshams 1 year ago
thats not how it works. Pt binds, mmr proteins attempt to repair the damage and when it proves impossible they trigger apoptosis. thats why it doesnt work on cancer cells that lack mmr machinery. there is no alkylation/kink creating step.
martyalex 1 year ago
nice animation! However I have to agree with mforrest24 that the compuond that react with DNA is the diaqua compound. Also maybe you could improve the DNA-binding step. In the video the chlorine go away and then cisplatin react with the 2 Gs. Actually the reaction is more that the nitrogen on the G attacks the Pt atom displacing the OH2 groups. But again, is a very good job
gangelo79 1 year ago
Comment removed
Bubblographer 1 year ago
What happens to the chlorine?
allmakescombined 1 year ago
You misspelled "diffusion" in the video.
AmokBR 2 years ago
What's up with the song? lol
AmokBR 2 years ago 6
@AmokBR Its a song by Ratatat. I believe the song is called wildcat
CarnalDiafragma 1 year ago
@CarnalDiafragma Thx a bunch
AmokBR 1 year ago
Great video; however, cisplatin hydrolyzes after entering the cell in the aqua and diaqua, which is the form that attacks the DNA.
mforrest24 2 years ago
oh wonderful , thx really . nice job .
mehrshadpiano 2 years ago
Very helpful!
xcgrl287 2 years ago
Really good video, really help me understand how it word.
ThatHairyGuy 2 years ago