@brettis26 1) Abstinence (detox) or tapering off (alternate opioid maintenance, something natural and widely legal/available, as Kratom, or government controlled, as suboxone) 2) undiscovered epigenetic processes 3) rapid inverse signaling by co-administration of drug such as naloxone (non-detoxifying induced withdrawal) 4) NMDA antagonist drugs have been shown to lower tolerance (PCP, special K), 5) opioid peptides such as DAMGO seem to reverse sensitization (such as like an epigenetic process)
Finally an answer, though in our modern technical age I cannot believe we still do not have any answer for such a relatively simple problem to study. Its not like its cancer with an unpredictable occurance. You can in fact enable this effect on cue, shows our priorities. Were much more interested in developing hydrogen bombs and ICBMs than medical research.
Finally an answer, though in our modern technical age I cannot believe we still do not have any answer for such a relatively simple problem to study. Its not like its cancer with an unpredictable occurance. You can in fact enable this effect on cue.
So emotional! =) Although better voice recording and not such a cruel voice would be nice, overall the vedeo is very emotional, and because of it - easy to remember. ^.^
Nice and clear overview of opioid receptor down-regulation. I take opioids daily for severe chronic pain and have experienced tolerance. This video is a great way to help explain (well, potentially explain, since it is still not proven) tolerance to close family and friends who may have questions or concerns about opioids.
Thank you for this video. I'm using it to explain the similar process of benzodiazepine tolerance/GABA receptor down regulation to some folks.
lifelieswaiting 7 months ago
is there a way of lowering tolerance to opioids
brettis26 9 months ago
@brettis26 1) Abstinence (detox) or tapering off (alternate opioid maintenance, something natural and widely legal/available, as Kratom, or government controlled, as suboxone) 2) undiscovered epigenetic processes 3) rapid inverse signaling by co-administration of drug such as naloxone (non-detoxifying induced withdrawal) 4) NMDA antagonist drugs have been shown to lower tolerance (PCP, special K), 5) opioid peptides such as DAMGO seem to reverse sensitization (such as like an epigenetic process)
Raflegan 4 months ago
@brettis26 Stop taking them.
csincali 4 months ago
@brettis26 take a tiny bit less one day, then take the usual the next you will notice the difference
GOwFrEak360 3 months ago
@GOwFrEak360 thanks for your reply.
brettis26 3 months ago
LDN!!!
presouz 10 months ago
Finally an answer, though in our modern technical age I cannot believe we still do not have any answer for such a relatively simple problem to study. Its not like its cancer with an unpredictable occurance. You can in fact enable this effect on cue, shows our priorities. Were much more interested in developing hydrogen bombs and ICBMs than medical research.
sebastian869 10 months ago
Finally an answer, though in our modern technical age I cannot believe we still do not have any answer for such a relatively simple problem to study. Its not like its cancer with an unpredictable occurance. You can in fact enable this effect on cue.
sebastian869 10 months ago
So emotional! =) Although better voice recording and not such a cruel voice would be nice, overall the vedeo is very emotional, and because of it - easy to remember. ^.^
IBMua 11 months ago
Freaking fantastic explanation! Well done sir.
ItsNeuroscience 1 year ago
I tried watching the video but youtube is such a goddamn piece of shit
gooddeath 1 year ago
Nice and clear overview of opioid receptor down-regulation. I take opioids daily for severe chronic pain and have experienced tolerance. This video is a great way to help explain (well, potentially explain, since it is still not proven) tolerance to close family and friends who may have questions or concerns about opioids.
jerseyemt 1 year ago