mRNA Translation (Advanced)

[Unic0rnendrainb0wz]

This is the worst animation ever.....

[2219155]

what about initiation factors?

[mtmorgan90]

Advanced?! Psh. It did not explain elongation or initiation factors...

[texag713]

"Advanced" and nothing about Chaperonin eh?

[eliastop]

what is rRNA?

[Tomwenn]

@eliastop ribosomal RNA

[mtmorgan90]

@eliastop It is called ribosomal RNA and contains structures and enzymes necessary for the synthesis of proteins. I hope that helps a little :)

[TimwiTerby]

Aaaaarrrggh interlacing aaarrrgghh hatehatehate!

[deliciousfishtacos]

staring at all the t-RNA hurt my eyes

[TheKwest1455]

this youtube channel is gonna be useful...i hope

[hwelham18]

This is barely more advanced that A Level. Nice animation anyway

[wellplayednessy]

This is absolutely brilliant! Perfect for my AP Bio class! Thank you!

[MrCarlover1]

@wellplayednessy ha this is my regular bio class

[norman191000]

how do they know about this process in such a detail?

What is the methodology of gathering motion data of such a small units?

[DrStasso]

@norman191000 These are simulations, there has never been motion capture of something so small (not to my knowledge at least). By sequencing the various subunits and studying the crystal structures of the transitions states of the reactions we can imply the mechanisms and the chemistry behind them.

[sinachiniforoosh]

@DrStasso but I think it does happen after all, right?

[pawelpap9]

@DrStasso These are not simulations, these are animations, incorrect I may add. Both electron microscopy and X-ray crystallography allow one to see at least some of the events at a sufficient scale of details.

[theeHeisenberg]

it's called advanced because of the super hi def graphics

[hafizzainudin92]

i guess it is not advance enough for a biological diploma

[MrMrPyruvate]

its advanced because they use crystallography 3D models to explain it i guess

[spotlightman1234]

@LughGarrick The thing is that on such small scales like this we're talking about, molecules move relatively very fast. This animation being showed is slowed way down so you can see what is going on. In reality ribosomes can make hundreds of proteins a second.

[missmertueil]

@LughGarrick way

[9klam9]

I'm fucked.

[colinwar]

im impressed, This seems as real a animation that is possible at this point.

[RenaissanceTheClown]

2:30 - "The spent tRNA"? lol, molecular sex

[RyanGenX2]

cool animation but I wouldn't go as far as calling it "advanced" before it at least includes Initiating Factors and Elongating Factors.

[Wandelaarke]

they forgot to mention precursor RNA is made first... which then changes to functional RNA by cutting out the intrones (RNA-splicing)

anyway, this video is wicked :D

[anvoodoo]

does it "read" this mRNA fr 5' to 3" so the 5' in this video is on the left???

[ThomasWinkworth]

damn it's like a factory of robots

[Treckorz]

@ThomasWinkworth  Yeh science proovs that evolution is bullshit.

[Guardian9191]

@Treckorz Say what?

[nichtmuttersprachler]

@Treckorz To claim that "evolution is bullshit" is to reveal a profound level of ignorance and a deep misunderstanding of basic science (or the fact that you might be trolling). The theory of evolution is a well-substantiated scientific model that has survived rigorous scrutiny as it has remarkable explanatory and predictive power.

[Wandelaarke]

@Treckorz Ugh... go cry in a cave or something, who knows god will appear.

[JeremiasMezenga]

"No designer is needed..." rs

[delryn256]

I wanted to know about promoters, and the Shine-Delgarno sequence :(

[Vanna0111]

Maybe the "advanced" is for the graphics...

[IloveYOUviruses]

:s this aint advanced

[demise3601]

this aint advanced. its miss all the protien factors!

[NinjaNate]

This is awesome, quick brushup before a quiz.. Thanks :]

[skippy1222]

Do you have a more advanced video than this (maybe one that includes elongation factors and initiation factors?). I'm having trouble visualizing EF-Tu-GTP hydrolysis..

[Nikvaylo]

Actually its not a advanced. If it is named as "advanced" it should contain some informations about initiation factors...

[dnrongo]

@Nikvaylo And aminoacyl-synthase

[clbarlow89]

The RIBOSOME pulls itself ALONG the mRNA! The mRNA is not fed through the ribosome! And the A site is not the first in the chain (to be used), the Psite is!

[poweredbychi]

@cbernier that makes you sound like an arrogant tool

[cbernier3]

@poweredbychi I was being nice and encouraging, you sound like an asshole.

[IceTeaEdwin]

@cbernier3 LOL

[jesusfish305]

doesnt the ribosome move thru the mRNA, not vice versa s they mentioned here?

[hartistry1957]

What makes the base transfer molecule position itself so precisely as to put the amino acid building blocks in exact 3s inside the machine? FUCK! WOW!

[cbernier3]

@hartistry1957 Your science knowledge isn't advanced enough to answer this question, but if you study hard, you will learn the answer.

[hartistry1957]

@cbernier3 If you're going to be pompous asswipe arrogant cumstain; please do the courtesy of proving some measure of your pseudo intellect; abeit, fruitless.

[cbernier3]

@hartistry1957 Considering he doesn't use correct terms, considering this was surprising news to him, and considering he swore about it, I would have to estimate his biochemistry knowledge to be around high school level, which is typical of just about everyone. OK, if you want a simple answer, this video isn't accurate, and it doesn't properly show the small subunit. The small subunit is what helps keep the mRNA from slipping. An advanced answer requires graduate level chemistry and biochemisty.

[hartistry1957]

@cbernier3 Thanks for your verbose reply sir. I love science and how the world works; it is a passion/hobby of mine. You were pretty close in assuming ed level aside from non-grad college-level Chemistry. The only things in the physical world I question are the laws of attraction and repulsion; if weak forces and all of the other energy fields react by a set chemical formula or a kinetic one, that still doesn't explain the cause and effect purpose or intended (or random) result.

Your thoughts?

[DeMoNiOMx]

im working now with 5S rRNA the small RNA in the Large subunit in Leishmania major :) I used this video to show te ribosome to my friends. So they can got and idea about my work :D.

[Jopau18]

this is not advanced....

[cbernier3]

@Jopau18 It depends on who you are. This is pretty advanced for a high school student, but it is not advanced at all for a graduate student.

[mehrshadpiano]

that was very nice and useful . thank you very much .

[droznig]

If this is advanced, i would hate to see the basic.

[quitejaded]

@droznig THe basic is the same. I thought "If this is the basic, I'd hate to see the advanced!"