Multiple Sclerosis T Cell Receptor Diversity

[hoogiechugie]

is he part of the mafia?

[kkkkkkatherine]

"cellmedicine" Thank you!! I feel Hopeful re: MS treatments finally!

Truly I will not presume to have the cognitive utilization of all the info you present here, but I sure DO appreciate your efforts...Please dismiss Negative Comments...I am certain the Majority are most appreciative ultimately! I certainly am.

[cellmedicine]

Dear Kkkkkkkatherine, thank you for much for your kind commments!!  This really means a lot !

all the best

[christineball33]

It would be interesting to use this immunoscope to see if mesenchymal stem cell therapy actually modifies the clonotypes during the progress of autoimmunity. The paper is saying that its not just about proliferative responses but about the specific clones that are responding, so we need to study clones not overall responsiveness. This kind of throws science into a completely different direction. It is similar to how the tumor stem cell theory threw away decades of research.

[taniawatts]

Epitope spreading is also something that needs to be understood. The root cause is propably multifactorial, however some of the innate immune activators such as bacteria/viral infections may not only serve as molecular mimicry but also stimulate epitope spreading so that cells which normally would react to foreign pathogens would start responding to self antigens such as myelin basic protein.

Great video

[ameeek]

Where are the stem cells in this?

[emirapper]

stem cells in the dendate gyrus, this is affected by ms?

[floricabatu]

I have heard about the great progress by the Canadian company you mentioned, however this is only in a some patients. Not everyone responds. It is irresponsible to talk about a cure when we are so far away.

Shame on you

[cellmedicine]

Did I mention a cure ANYWHERE in this video???

[jonlamarre]

Understanding the immunology of this disease is important since there are many types of autoimmune diseases that all work on the same priniciple of a T cell recognizing and attacking sometthing that it should not be attacking in the body. Rheumatoid arthritis, diabetes (type 1), and lupus are autoimmune.

What is also interesting is that stem cells may be able to effect the autoimmune processes. Remember Osiris, the company most advanced in US stem cells is treating autoimmnity

[troopermission]

BioMS uses intravenous tolerance, would be interesting to see if oral tolerance works. If I remember correctly there was one company that was trying autopeptides by oral tolerance.

[crazedromanian]

multiple sclerosis has been successfully treated by peptide therapeutics such as the myelin basic protein peptide being made by the endomonton company BioMS, next time you should discuss this Tom

[stemcellscientist]

look at the paper Du et al Chlamydia pneumoniae infection of the central nervous system worsens experimental allergic encephalitis. J Exp Med. 2002 Dec 16;196(12):1639-44.

It provides strong rationale the initiating events are bacterial in nature

[stemcellscientist]

I understant that T cells are involved in the maintanence of multiple sclerosis but the initiation has to come from something. There has been data published that bacterial infecitons actually stimulate multiple sclerosis clinically and that some animal models of multiple sclerosis are actually accelerated by co-infecton with bacteria. So I think that we should be studying more tha actual causes instead of interoggating sublte differences that will not necessarily produce any cures or benefits

[7mumfred7]

I completely agree. What is the point of talking about peculiar differences between this T-cell and that T-cell? It is BS to look at these diverse effects without looking at the root causes.

[cellmedicine]

And how my dear do you propose we do this? Here I am wasting my time putting up videos so that we may share ideas and learn and you guys make fun of it? why dont you responde with a video about root causes? Here i can tell you right now one...chlamidya pneumonia ...some have implicated this in MS...do a video on that

[angelafreedman21]

Not only an expert in stem cells, this guy is a great immunologist !! amazing work