Levamisole is a potent anthelmintic drug, which is used to eradicate nematode infestations in a number of domestic animals. Application of Levamisole to wild type C. elegans causes muscle hypercontraction, paralysis, and ultimately death, although the exact cause of death is unknown. It is thought that since the animals do not store nutrition and are constantly passing nutrition and Oxygen fluids around themselves that the paralysis isolates them from respiration and the Nematode dies.
I don't see why the nematomes weren't killed with levamisole cos everytime I've treated with it they were all gone. You have to do 3 treatments on 3 weeks of 250mg/10 gallons each time and you have to vaccum and change ¾ of the water the third day of the treatment. ;-))
@Boupette Levamisole doesn't kill camallanus worms, or most worms for that matter. What it does is paralyze them and allow the fish to pass the worms. Thats why you have to change a lot of the water and clean the tank very good to get rid of them, because they are not actually dead yet. Repeat doses are to take care of any larval stages that reinfect the fish. Levamisole worked just like it was suppose to in this video.
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 41, Issue of October 8, pp. 42476–42483, 2004 © 2004 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A.
"The Caenorhabditis elegans unc-63 Gene Encodes a Levamisole- sensitive Nicotinic Acetylcholine Receptor alpha Subunit"
and several other studies on the developed resistance to Levamisole have been done to pinpoint the actual cause of death.
inkmaker01 2 months ago
Levamisole is a potent anthelmintic drug, which is used to eradicate nematode infestations in a number of domestic animals. Application of Levamisole to wild type C. elegans causes muscle hypercontraction, paralysis, and ultimately death, although the exact cause of death is unknown. It is thought that since the animals do not store nutrition and are constantly passing nutrition and Oxygen fluids around themselves that the paralysis isolates them from respiration and the Nematode dies.
inkmaker01 2 months ago
Very interesting video, thanks.
I don't see why the nematomes weren't killed with levamisole cos everytime I've treated with it they were all gone. You have to do 3 treatments on 3 weeks of 250mg/10 gallons each time and you have to vaccum and change ¾ of the water the third day of the treatment. ;-))
Boupette 2 months ago
@Boupette Levamisole doesn't kill camallanus worms, or most worms for that matter. What it does is paralyze them and allow the fish to pass the worms. Thats why you have to change a lot of the water and clean the tank very good to get rid of them, because they are not actually dead yet. Repeat doses are to take care of any larval stages that reinfect the fish. Levamisole worked just like it was suppose to in this video.
mikaila31 2 months ago
I was wondering if i should like this for the awesomeness of the footage, or dislike it for the distate for camallanus.
GroinStabbingPro 3 months ago