Lec 6 | MIT 7.014 Introductory Biology, Spring 2005

[ForexReviewsCentral]

The explanation is simple but compact,.

[yamanutrition]

those NADH supplement is safe for oral consumption?

[MrSub4]

what happens is the athlete starts running like the wind.

[canuckythe]

can anyone give me a detailed explanation for pyruvate oxidation? How does NAD+ convert to NADH? where does the 2 H atoms come from. When the carboxyl group is removed as CO2, what happens to the Hydrogen? How is the 2 carbon compound after decarboxylation an acetate group. Why is that reaction a redox?

[Blackfiria]

its an introductory course...........what a stupid comment

[0879664946]

Thank you very much, very clear and concise :)

[hpy1008yin]

very clear!  Thanks for the lecture.

[Aqualle]

Thank you so much for the lectures!!

[abdurrauff]

catalysts work by providing a different reaction pathway which requires a lower activation energy,

it does not lower the activation energy it provides a different pathway

[psandbergnz]

Also which has higher energy: NAD+ or NADH? NAD+ looks more unstable to me (so higher energy?), but the NADH has a lot of electronic energy, which it releases on oxidation to produce ATP.

[Blackfiria]

its a bit late(studyn for my exams now only just found this vid) but would you still like an answer?

[psandbergnz]

Blackfiria, yes I would appreciate an answer.

[Blackfiria]

NADH is broken down to NAD+ through the Electron Transport Chain (ETC) and the NADH Dehydrogenase Complex ( the first proton pump in the ETC, it has a higher affinity for electrons and therefore strips the NADH of the 2 high energy electrons and the proton H+, this happens thru out the ETC (search for info on this, thr is alot on youtube) the mitochondria taps into the proton graident from the pumping of these protons and produces ATP from the energy.

[psandbergnz]

This is a wonderfully explained series of lectures - many thanks.

I have one question (at 30 mins): The conversion of glyceraldehyde-3-phosphate to 1,3-BPG releases much energy, and NADH is produced. But the product 1,3-BPG is high energy (since unstable with its two phosphates). So, WHERE is the energy coming from to drive the reaction? Is it the oxidation of the aldehyde to the carboxylate that releases the required energy, or does it come from reduction of NAD+ to NADH (or both)?