Stem Cell Therapy for Critical Limb Ischemia

[mensionwillrule]

cxcr4 antagonist, but i thort CXCR4 IS to let stem cell home?

[cellmedicine]

I LOVE YOUR QUESTION!! YOU are dead-on...CXCR4 binds SDF-1 which is made by bone marrow stromal cells constituteively ...my understanding is that the forces that hold the stem cells on the bone marrow stroma always need to be there otherwise mobilization happens...so the CXCR4 antagonist blocks the "pulling" of the BM stroma on the stem cells and releases them into circulation...but like you said, maybe they will not home to the ischemic tissue since their CXCR-4 is blocked from sensing the SDF

[SeanGizzle]

good

[floricabatu]

The use of stem cells therapeutically holds much promise, especially in conditions associated with lack of oxygen due to constricted blood flow such as critical limb ischemia. Great job Cellmedicine !! I am glad your posting about treatments you offer

[skatergirl333]

I am going to try to respond to this video with a video i found about keith march at indiana doing a similar procedure here in the US.

[stemcellscientist]

Great paper cellmedicine. Did you guys see the work from indiana? they talk about using stem cells for the same critical limb ischemia that your talking about.

[troopermission]

Great Job !!!!! Stem Cells are very important but even more impiortnnt is for peopel to understand that stem cell therapeutics is actually used today. Stem Cells are not a thing of the future but a medical reality.