Glycolysis

[don145arsenal]

if u dont do a medical related course at uni level, this will not make any sense

[DaNerdOfRS]

Totally need this for AP bio, thanks alot!

[leslietzy]

This is amazing, I feel incredible, yes yes yes yes I can win I feel great I can do this urgghhh

[islamiaarabia]

Wow, we all came here 'cause we have finals. :D

[VeraciousAmI]

I don't think I need to memorize this for my AP Bio test on cells, but it was very helpful. I actually copied down every single reaction/step. This should come in handy some day when I actually need to memorize it all. :)

[secondandtube]

thank you

your video is really helpful for my tomorrow biochem exam.

[elanajoy86]

I really hope this is MORE than I need to understand to pass my bio exam tomorrow!

[rockstarforevr]

wtf, im screwed...ughhhh how the hell am i supposed 2 memorize all this?:(

[Xploitzer]

I want this woman to go to my medicine exam and get 100% good answers

[wasianwigger]

great vid.

[GeneralShadow]

I still have no idea how energy comes from splitting molecules or putting them together. Where does the ATP come from?? o__o

[1Abdilatif1]

@GeneralShadow Split molecules up you get free energy in the form of electrons which NAD+ captures to become NADH and free energy in the form of phosphate groups which ADP captures to become ATP. Also ATP is floating around in the cell, so is inorganic phosphate groups and many other minerals/vitamins, and things like water, sodium, etc... ALL FLOAT IN CYTOSOL IN CELL. I am not a pro, just a student, take these results with a grain of salt and have a great day!

[hailthefsm]

@GeneralShadow ATP is made in ATPase, and its not that it makes ATP, it just converts it into a form which we can use to survive.

[starlette098]

@hailthefsm Also, why is alpha-D-fuctose-6-P shown? Should it not be beta since that is it's most stable conformation?

[HomerJ666]

@hailthefsm r u serious? ATP is split in ATPase (e.g. Na-K-ATPase for active transport, which uses ATP as energy source)

[SLCforLIFE]

It's tough to understand all you students out there! But you'll get it and it's shocking. Keep studying to expand your brain.

[bam8195]

Misleading video of horribly inaccurate reactions: eg. in step 1 that ATP molecule is NOT at physiological pH, it's protonated even though the pKas of the hydrogens are less than ~7.2. Also, in this same step, you portray a basic site of the enzyme removing the proton off a hydroxyl - but this would not occur because the site would not be basic enough, nor would the alcohol be acidic enough for this process to occur. The oxygen should have been displayed as the nuc then the base removes proton

[lyricaltesting]

@bam8195 It wasn't made to go into that kind of detail. This is a video more for First year University students, not someone working on their Doctorate!

[shadyDAitalian]

learing in 9th grade bio and have only 2 days to learn a bit outragoues if you ask me, but I guess I'll just have to really study, this sorta helped thanks!!

[whamilton1221]

Wow this even includes the mechanisms of the reactions - really amazing, thanks!

[hockong]

awesome!! =] thanks for sharing~

[Wii624]

This makes absolutely no sense. Seems too complicated to actually be happening in real life :P

[noshyfication]

Awesome video! So easy to follow

[marycontrary]

Great video! Thank You:)

[metaitachi]

Im learning this in the beginning of grade 12 bio...

[carlrod90]

i only get 6:53

[arunkiitm007]

awesome!!!!

[kamilchad]

This video saved my life!! But I probably got a little to hung up on the details lol.

[sonic42797]

University at Buffalo. Biochemistry 403



[ff2paladin]

@sonic42797 Yeah, I got this tomorrow too. Good luck

[katrina404]

this makes sense!

[dier69]

Absolutely amazing video! Thank you!

[BabyColor]

uh, did i see it wrong or there really 4 ATP at the 6:45?

[AHungryDino]

@BabyColor You did not see it wrong. There are 4 ATP molecules generated throughout glycolysis, but since there were two spent to make the four, there is a NET gain of 2 ATP and 2 NADH. As you progress through the Krebs and Oxidative Phosphorylation complexes, the NADH (and FADH2 from Kreb's) are used to drive the proton gradients required for the Electron Transport Chain (in Oxid. Phos.). This generates 34 ATP, and with the two from glycolysis, there is a gain of 36 ATP from 1 glucose molecule.

[BabyColor]

@AHungryDino Ah thats explain it, thanx a lot man

[MsKievStar]

Great job! Very helpful! Especially the transfer of electrons schematics. Made it really clear how reachtion happens.

[justin2793]

Well i think i'm screwed for my exam

[soccrfan101]

7 minutes of "wtf?"

[starlette098]

@soccrfan101 My thoughts exactly! :/

[thinkmanworld]

just wanna.. how the molecules know which steps n then.?

[gabymm1]

fuckin biochem....

[ejasw]

Perfect! Thanks a lot!



[phlqxz]

@wyvern175: none

[benildaramos]

how will i download this video?

[ryuuwyvern90]

Thankyou so much. This helped break it down. I was given 4 steps in my lecture.. This was much clearer!

[Aquolyte]

Thank you! This is one of the only videos I've seen that used the full names of all the intermediates and the enzymes!!

[caraannie14]

i think im the only school learning this in bio... not chem

[ryuuwyvern90]

@caraannie14

Learning it in First year Biology at University!

[policefreakz]

wtf?,,,, why have i left glycolysis till the last minute?- my exam's tomorrow and i have to somehow remember all of this off by heart !!!

[wyvern175]

Whats the difference between glycolysis in aerobic and anaerobic environment?

[BabyColor]

@wyvern175 i think there's no diference in glycolysis itself, instead it differ in what the piruvate acid do next

[dysvanlist]

Can somebody explain how other monosacharides are used? like fructose.

[fvboss429]

@dysvanlist fructose gets in when fructose 6-fosfate is formed (step 2)

galactose (i'm portuguese dont know if its called like this in english) enters when glucose 6-fosfate is formed (step1) ;)

[nosferato06]

This is the best explanation of glycolysis out there!! Along with the Krebs cycle and Electron transport chain videos Garland Science have made these processes much more palatable!! :D

Thanks for the hard work! ;)

[qrais]

omg this is so much more complex than the explanation in my book

[qrais]

lol this is so more cplex than what my chemistry book indicates

[sachinxylo]

awesome,

[biscuitfinger]

Another brilliant video from Garland Science!!



[Zlopras]

wonderful, expertly done, the best way to explain glycolysis. greeting from the Czech Republic!

[khhhaalid]

biochemistry sucks i hate it

[gbodkin1]

perfect explanation, and thanks for including the organic aspect. awesome job!

[beefhat1]

awesome video garlandscience, great explanation

[formula1nh]

good job I learnt about all the organic reactions such as elimination reactions, nucleophilic substitution and electrophilic addition reaction in the first year of my course, pheewww otherwise it woudnt be easy

[afshanz]

Thanks this really helped me in my bio 2 class!

[Randizzil]

huh?

[andycole1989]

I understand this is for an intro cell biology class, however, organic folks please be wary of these mechanisms for they have a few errors placed for what I assume is convenience. For example in step four they have a hydroxide leaving group which is impossible. They also leave out some important mechanistic elements. It is good for biologists however this should not be the only tool for biochemists who need to understand the details of all the mechanisms.

[dkishr]

Very helpful!!! Thanks!

[stasop]

i like everything but they dont put the name of the enzyme

[kereflkn]

This is the best glycolysis process breakdown video I've found. Thank you!!

[LasQoray15]

I bet shes reading from a paper and im meant to memorize this stuff :(

[tricky317]

I love science... BUT CHEMISTRY IS NOT SCIENCE IT'S MATH IN UNDER A FANCY NAME

[LazyMegalonychidae]

Great vid.

Simple animation, and straight to the point.

Very useful overview of the process in the end - Thanks alot!

[rodeo179]

great video if you understand organic chemistry. .. thank you!!!

[Adagio1723]

glycolysis? more like lame-colysis. this is pure torture son.

[HakimAsad]

If u don't mind can u put the lyrics so I can memorize the song :)

I really love it

[Sneery69]

Oh my, it's gonna be a hard two weeks until exams... But thanks very much for the vid, it really helps.

[SkinnyThiago]

procrastinationnnnnn ahhhhh.... im gonna memorize all of this -_-

[docnot1986]

while studying biochem any voice especially from a girl its sexy ...

hate biochem

[jaimefsy]

thank you it helps a lot thanks(100x)

love ur voice

[mgreer2]

@MindAndMarzipan 6:34-7:07 Two ATP molecules are used up in steps 1-3 while 4 are released steps 7-10

[MindAndMarzipan]

@mgreer2 TY :)

[MindAndMarzipan]

Don't you end up with 4 ATP? 2 for each glyceraldehyde-3-phosphate? Please take the time to answer as I am teaching myself.

[brmuss]

@MindAndMarzipan

at the beginning of glycolysis 2 ATP are used to phosphorylate the molecules.

Near the end four ATP are made ( two from each glyceraldehyde 3 pyruvate molecule) so there is a net gain of only 2 atp.

[murphcon79]

@MindAndMarzipan at the end of glycolysis you do end up with 4 ATP but... you gain a net gain of 2 ATP so basically 2 ATP go in 4 ATP come out

so 4 ATP (from the end of the process) - 2 ATP (to start the process ) = 2 ATP (net gain)

[MindAndMarzipan]

@murphcon79  I got it. Thanks.

[joeynap860]

probably the best glycolysis video on here.thumbs up for that!

[patriciaabellaa]

thank you. :D

[fineserbian]

This video is amazing!! Thank you so much for sharing.

[Bfffness]

awesome... finally found one with all the details.

[jasraj123ful]

it helpred alot alot n alot

[WaYneD91]

@jasraj123ful do u know the difference between the aerobic & atp energy system?

[joeynap860]

great vid

[jetbeing]

glycolysis

[morbidpancakes]

So much better than staring at my diagram in my course guide, thank you!

[Aregowa]

ehh.. I kind of understand... but when i hear a name i suddenly forget everything... why aren't the phosphoglycerates just called bob?!

[Chickensteak192]

i love how the ATP zooms out towards you

[TheMaralara]

The best video of glycolysis ever! :) Helped me a LOT! Very clean, easy to understand, nice soft voice.

[oneyay]

how did glyolisis come about if is an energy producing pathway but requires energy b4 it makes energy where did the 1st engery come from u fk tards :P:P

[ac14081408]

@oneyay this is the step that proves the hand of god must have done it.

[jesca215]

PERFECT Video!! thanks!

[MegaMinnieminnie]

Im glad I dont have to memorize this stuff for my exam, but this video makes the proccess so beautiful..........I wonder if i would say that if I had 2 memorize it all.:)

[ravuthpum]

Biochem students unite!

[bennhanny01]

that is just ....wow!! mechanisms and explanation are great!!! good job :)

[hurdlegurl521]

This video is awesome!! I need to memorize this whole thing by tomorrow =/

[Graaaady]

Nice.

[melbourneopera]

It is more like Nucleophile and Electrophile stuff

likeThan beta-elimination alpha-substitution.....Lol....­Love this video

[anwaro]

im watching this movie right before my test.. lol n I ACTUALLY LEARNED SOMETHING!!!

[swangle]

@anwaro How could you learn ANYTHING from this mess? More than 46 percent of the information is made up. Get a clue, please and thank you:)

[anwaro]

@swangle wtf is ur damage.. im not stupid like u, i can understand it.. i dont need ur fuken advice.. fuk of

[JNScott65]

Until watching your video, I had a very hard time with these steps. Thanks so much for a clear and fantastic tool!

[swangle]

Regarding 23 secods into the video: Pyruvate has consistently been shown NOT to be imported into the mitochondria. Rather, it is exported outside, via diffusion, recruiting lymph to assist with the glycolosis. Whomever put this video together has obviously never read Dr. Oldengards classic work, Glycolysis in the Modern Day.This video is a slap in the face to scientists around the world. SHAME!!!

[shuff18]

@swangle wow ur hard.

[purerocker7]

many thanks!

[oprahfan100]

thank you.....hu

[WarrenChristianXVIII]

nice :)

[tde1985]

wow... i cant believe i practically have to memorize all of this.. bad times :/ .. thanks for the video tho!

[StAnger561to770]

hahaha yeah I fell your pain! I have an exam on this stuff this week eh I need to know all the enzymes involved and then some plus some junk about gibbs free energy. Yawn! ah well this video was very detailed though.

[bodiebot]

At last a video on the subject that makes sense. Thank you.

[SirBigBrain]

OH MY GOD ITS GOT A GUN!

[toresauro]

You are a very usefull prof. :)

[Sillybean28]

This is very well explained! I need to know all these details, such as each of the enzymes involved and what changes occur during the breakdown of glucose. I thank you for posting this!

[mandaisme1]

Great Stuff!

[antonima1]

you've got to ask yourelf- if we have such great videos available to the public via youtube, what is the point of memorizing it??

[Knockturnnall]

thank you SO MUCH! -College student

[caifuge]

thank you! this is very detailed and the animation helped a lot!

[XpliciTTRecords]

nice nice i learned alot thanks thanks

[xhotshot12]

muy nice

[copesnuffs]

Best video on earth! (Biochem major here)

[TheMonicaadame]

Its like I'm hearing another language!

[williamLA7]

awesome

[ayaloloable]

bad explanation

[limeOjello]

AHHH! I love it!

[BojanKrkicone]

Can anyone explain phosphorylation? I find that concept hard to grasp..

[blilie]

Phosphorylation is when a phosphate group is added to another organic compound - not necessarily ADP...

[MsBigdave12]

Dont enzymes do the same thing?They bond to a phosphate and then they use it to make a reaction occur.

[ArtOfPhire]

Awesome video.

[cloudyiday]

i. love. this. video.

[087675039]

wow this is awesome

Thank you!!

[kandu813]

this is so awesome, i love animations

[joanestelar]

PERFECT. THANKS SO MUCH!

[pogon4life]

Gotta love her sexy voice...

[Tahmmo]

Indeeeeed, hehe

[micchram]

Thank you! This helped me so much for my BioChem class!

[nadrah911]

soooooooooo cool , this is amising

[sensation2ve]

SOOOOOOOOOOOOOO HELPFUL!!! thanks alot!