Super Coiling of DNA

[Armondahad]

which song is this?? i looked through the soundtracks and couldn't find it... nice vid btw

[LSDelusions]

If only they showed this at school and university... Every kid and I mean EVERY kid, would wanna end up being a biologist (and cry afterwords but this another aspect :P)

[dm57777]

@LSDelusions Professor Bermingham at UVM just played this today in class, it received an ovation. She pumped up the music too!

[SuperLLL]

very cool video...but isn't this just the regular coiling of the double helix around the histones?Isn't supercoiling involving DNA gyrase or topoisomerase II?

[zenithar6666]

just another result of our beloved random mutations and natural selction, give me afucking break

[SteU4IA]

AND THAT! Ladies and gentlemen...is how our cells can pack in 1m of dna

[ScienceFan1859]

@SteU4IA if you're talking human cells, it's 2 m...even more amazing!

[SteU4IA]

@ScienceFan1859 that's right 2m for diploids and 1m for haploid cells.

[alliieexoxo7]

So cool

[V0dkaLove]

The ending - so good.  Music was perfect!

[AZNKC]

this is just.... so awesome

[75trink]

cool video

[cheyofeeba]

SO MELODRAMATIC!!!!!!!!!!!!!!!!!!­!!

[sport3290]

chuck norris was the one doing the coiling.

[MegaOmik]

I believe that after coiling within the supercoil comes one more stage, when it starts supercoiling witin chromosome, and then this supercoil within chromosome forms the chromosome.

[traceytang2391]

thu music is awful

[irisrthr]

It's simply just awesome~I hope the resolution could be better~

[AdmiralPancake]

This is so awesome.. Really helped me understanding it as well!

[LynciLuv]

I loved that......Nice

[artwelve22]

amazing.

[admarshall617]

that is beautiful

[IDdoc3]

This is not DNA supercoiling (defined in the process of creating coils in DNA under tension during replication). This is the packaging of DNA with histones and non-histone DNA-packaging proteins into chromatin

[roddyjojo]

To answer the question of how many levels of coiling there are:

it can be determined mathematically.

A very generic equation is L = T +Wr, where L is the linking number (the number of crosses one strand makes over the other) T is the 'twist' (number of twists of the double-helix) and Wr is writhe (the number of coils). This is approximate for B-DNA.

Check Wikipedia for examples. Writhe is numberically definitive for supercoiling.

Software can be used for more accurate determinations

[yuvayuvaraj]

g88888888888888888888888888888­888888888888888888888888888888­88888



[joycebaby76]

What is the song?

[picardposer]

@joycebaby76 the music is from Kill Bill when bill stumbles into the yard

[anonnemus]

@picardposer haha after the five point palm heart exploding technique

[permatroll]

@picardposer can you PLEASE tell me the source of this animation? It's pretty awesome! :D

[timrob62]

Wow. Coils of coils of coils. How many coil levels are there?

[mushroomsftw]

Whoa

[brotdher]

How did you do this?

[jazz0900]

FML this is amazing

[leesway]

Gangster. I like it. Thumbs up.

[goblue10nis]

this is the most epic video i have ever seen in my life

[picardposer]

you made be blush:most...epic...ever. Hi praise and sincere thanks back at you!

[Robbybox333]

So, are the "rubber band" twists that emerge at the end supposed to be looped domains?

What can you tell me about the reference material used for this animation?

[roconnor6391]

Luv, Luv the video. No, voice over to complicate the visual.

[Nogard229]

Ah, a chromosome.

[watifimnot]

i love the dramatization with the song, especially towards the end. it made the chromosome feel like a giant cactus. idk im weird.

[munchkin0518]

Just wondering, where do histones come in? Were they the little balls that came around 0:21?

[picardposer]

The spheres are the histones. Think of a spool with DNA as thread. Although recent research indicates the histones may play role(s) in gene regulation.

[zorinho07]

the beadlike structures are a chromatin which is a complex of DNA and histones.

[garydus]

Well done

[nashertheatheist]

Cut an elastic band so it is just one long piece of elastic, then twist it and twist it and these shapes appear.

[tamsi93]

Nice!

[smil3yn]

awes0me!!! great vid n help me a l0t!! n_n

[hzh27]

This is more properly described as DNA packaging where supercoiling allows DNA to be greatly compacted. Supercoiling of DNA may occur in many circumstances at all stages of the cell cycle.

[metalhead633]

GREAT! :D

[Subspace4d]

Thank you for this video. I had also one video of this coiling but yours is also great. 5 Stars

[IluvJesus610]

thank you, I wish there was an explanation along with the vid

[picardposer]

I added explanation to description.  Hope it clarifies things.