Macrophage Cytokine Release

[felixthemaster1]

lol fail T HELPER CELLS release cyto kines

macrophages help that specific T helper cell to multiply

[Thoggy78]

@felixthemaster1 lots of cells including T helper cells AND macrophages release cytokines, which is a large molecule family. Wikipedia is your friend (or your biology teacher could have been also ^^)...

[felixthemaster1]

@Thoggy78 really? maybe we just didnt learn that part yet!

[octavoch]

Ok i get that cytokines are produced but can anyone explain WHY and HOW the cell is able to do this? im somewhat confused. im trying to look it up see what i find lol

[PowerfulFellow]

NOMNOMNOM

[PinkSkiiTtLeZzYoanNa]

god must have created this world. it's too complex to be the experiment of some evolved alien civilisation

[Mahaveez]

@PinkSkiiTtLeZzYoanNa Ever heard of Shermer's Last Law?

[drjory91]

sob7an allah

[nuraini250]

cam nne nak download ek

[SWIFTzTrigger]

Why isnt there some sort of annotation, other than just "Macrophages" or "cytokines" a step to step would be ver helpful, not a big fan of narration though.

[datzfast]

@SWIFT Trigger its easy, the monocytes or macrophages if you will eat bacteria. then release soluble messengers in response to determinants on or in the bacteria. the release of these cytokines cause the migration of more macrophages against a concentration gradient to the site of cytokine release. further release by additional macrophages is referred to as a cytokine storm. sourse: DATZFAST

[SWIFTzTrigger]

@datzfast Thanks alot, not sure what determinants you mean though, since I would assume any bacterial infection would always stimulate the same response. btw I lolled at the "sourse: DATZFAST"

[LucasHolanda91]

WEIRD SONG...AH! WEIRD SONG...AH! WEIRD SONG...AH! WTF?

[xblueblaze]

@LucasHolanda91

I KNOW! :P

[tzeqin]

if these were learning tools back then, fewer would have dropped out of premed. But now that they have these tech, I suppose the standards will get even higher. Future Easy-level Question: "Assemble an animated 3D model to demonstrate the protocol that enables the ability of the macrophage to bind and internalize and trigger bacterial phagocytosis. You have 15 minutes for this segment." Swweeeet.

[saintsdancenrome]

I do not like the music in animated videos, they need more speakers identifying what the cells are doing, music detracts from proper info.

[jw2327]

@saintsdancenrome I agree 100%. This Video is almost BS without narration.

[Cizza225]

that thing looks creepy!

[judgeman21]

that's one big popcorn.

[JonThm]

Growing bacteria gice off nuclear radiation

[bubbles202]

OMG DID YOU GUYS SEE THAT!!! SO COOOOOLLLL!! I JUST WET MYSELF!!! THIS IS GOING ON MY FACEBOOK PAGE!!!! SWWWWWWEEEEEEETTTT!!

[rezaeijavan]

THAT WAS COOOOOOOOOOOOOOOOL !!!!!

[VikingStreaker]

Likely within the next ten years.

[nefertiti815]

wow that macrophage sent a whole army of white blood cells on the little germs

[bourbonstmc]

Damn these people do good animation. Why don't they just go the extra step and get writers and a narrator to produce complete films?

[MsLi7777]

yeah! it looks like a dendritic cell...

[gulchen123]

Isnt that a dendritic cell?

[vikingodc]

nope, it's a macrophage with its receptors catching antigens. after that he "eats" them and then he spreads cytokines to start the immune response which will activate diverse processes. One of those is to bring the Leukocytes to the infection site.

[JonThm]

@Username232011 IL-2 and IL-4 clear cancers in all times!

[JonThm]

IL-2 abd IL-4 will cure cancer adn heart disease

[magictree666]

crazy shit, theres a world goin on inside of us, so would that means we are a world inside sum other thing, DEEEP!!!

[vortechporsche]

praise Jesus christ? how about praising your immune system and evolution!

[ChickenWingChampion]

Do all macrophage work this way? This looks like dust cell. or is it in the blood?

[ChristTheKing2010]

this is soo cool. How our body works is amazing! Praise Jesus Christ!

[imahtuag]

no more thinking to admit this video is very good

[reydwarfpablo]

damn marvelous

citoquines are PROTEINS which are released to call another inmune cells like T or B lynfocites

[eastleidh]

anybody know the background music?

[JonThm]

A drip of IL-2 and IL-4 will start an immune action against cancer and heart disease.

[LBJohn15]

lmao like using your own ammo against you lol nice picture that going on every min like danm thats cool

[Kiryu1234]

Is it bad or good for you? xD

[PaxMasterTaskForce]

It's good. They eat bad/dead stuff. There's more, but I'm not sure.

[FnordPerfect]

Usually it's good, otherwise we wouldn't have it. If there is too much of the cytokines though they can also have negative effects - shock reactions etc.

[ALVAREZZ3000]

maya particles

[SuperGLaDOS]

I don't know much about the immune system, but this totally blows me away. To know this is probably going on inside me every minute of the day is so cool, when I am in the car, when I am sick, when I am sleeping. Just so totally amazing. It's so wonderful.

[datzfast]

@SuperGLaDOS My first textbook was mouse immunology. because human studies had not started. im retired now, but it donesnt mean im through learning.

[Twizler1000]

this is asome.even now i know alout about microbes

[delgadolaury]

ESTE ES

[U91H3D]

no its not a exploding penis ya sap

[GeeksGetGirls]

i didn't know that macrophages could release cytokines,i thought it was helper T that does it.

[Julianbts]

yup TNF alpha, IL-1 etc maaan!

[pookyboy85]

t cells and b cells recognize antigens in very different ways. b cells use thier surface bound antibodies as their receptor for antigen. b cells recognize specific shapes or epitopes that are present on intact antigen

[nauticapnoy12]

its the t cell that doesnt secrete antibody. T cell produce cytokines that originates from thymus.. Unfortunately thymus shink after puberty...

[Rahulioo]

sweetie Plasma cells are large B cells.

[Rahulioo]

1)APCS engulf an antigen.

2) MHC I and II goes on the surface of macrophages

3) T cells makes contact with APCs through CD28-b7, IL2 with IL2 receptor, and one more? lol

4) CTLS, Tc1 and Tc2 realese different cytotoxins. Tumor necrosis factor and, IFN-2 and 4 targets virus infected cells, tumor cells and self altered cells.

basic point APCs and cytotoxic t cells interchange info. through 3 ways. and all three ways important to kill the cell.

[U91H3D]

IL-22 & IL-4 Dont remove foregin substances they are a type of cytokine

[Spoksy]

bacteria get owned

[JonThm]

IL-2 and IL-4 will remove foreign stuctures from the body!

[wiiTneSs]

wow amazing and this is in our body!

[theotzaridis]

True.

[theotzaridis]

then again B-cells are rather unlikely, because i) they don't change their form that quickly and ii) we should be able to see some antibodies on their surface.

[zbjordan23]

umm...b-cells dont phagocytose...that cell in the animation clearly were phagocytosing some foreign antigen/microbe

[superderek]

B-cells do phagocytose.

they bind IgG and internalise it for Antigen presentation in the secondary immune response.

but this is obviously a macrophage

[welovesexxx]

B cells DO PHAGOCYTE!!!! and they present through CPH class 2 to LT

[Rahulioo]

B cells differentiate into Antibodies producing cells when exposed to an Ag. B cells already have millions of receptors (pre programmed) on there surface but once triggered by an Ag, goes thru slicing and Changes the whole Epitopes on B cells surface.

[theotzaridis]

Yeah, but macrophages also have millions of receptors on their surface and it is possible -in form of an allergy for example- that plasma-cells have antibodies on their surface and are triggered by a second exposure to the antigen-allergen. However in that case you are right, they wouldn't be b-cells,but plasma-cells.

[Rahulioo]

um i think all hypersensitivities are triggered by antibodies. Like IgE which triggers type 1.

1)Allergen to B cell

2) Th2 with B cell.(Cd4,IL4) Both need to stimulate B cell to make IgE secreting Plasma cell 3) Memory cell+Plasma cell 5) Allergen Specific IgE, Fc receptor for IgE 6) Binding of IgE to mast cell and sensitizing mast cell 7) Degranulation of mast cell 8) vasoactive amines triggering smooth muscle,eosinophill,mucous glands ( thus a lot of mucous) small blood vessel (swelling)

[Rahulioo]

I just thought about this right now while typing that aids patients can not have type1 hypersensitivity due to lacking Th cells?

[theotzaridis]

1) CD4 is on the Th2 cell and IL-4 plus IL-10 are released by it.

2) Between 5 and 6 there is also the crosslink of the IgEs, which are bound on the mastcells. It is the presupposition for the degranulation of mastcells and release of vasoactive substances, esp histamin.

[henzenr]

what is fake here?? you dumb idiot!! it's an animation about our body!!

[mualfa123]

That last statement is true. There are other cells which will release "down regulators" once the threat has been contained.

[jffryfnt]

Is it a macrophage or a dendritic cell. Hmm?

[theotzaridis]

Good point. It might even be a B-cell.Who knows?

[jffryfnt]

Could be!

[pr1216]

cytokines promote phagocytosis too

[dtrullo]

Cytokine is a chemical communicator among cells. It acts in small range or neighboring cells. An example of Cytokine are interferons they alert other cells that something is not right. Maybe you can think of then as an small scale hormone.

[bashibazouks77]

what does a cytokine do?

[zbjordan23]

there are lots of different kinds with lots of different functions...

[McTavishBear]

That's really smoothly done, a great video.

[c134567]

loving the presentation

[rdsa6]

omg amazing beautiful wish i can grow one macrophae in my fish tank

[cdyeager]

It's hard to believe something that seems like science fiction actually exists inside our human bodies. This biology 3D animation showing Macrophages releasing Cytokine is amazing! Good Work!

[CodeEphyon]

wow nice animation, Bonita animacion :D

[U91H3D]

this is what happens when the immune system is in overdrive.

cytokine is a good thing for us but the immune system releases a massive cytokine storm againt H5N1 that the levels of cytokine in our system can cause acute respiratory distress with can kill.

[1researcherdotcom]

Very very nice!!!

[Suki40330]

What an awesome video! I love it.

[jfurkdies]

EXCELLENT!!

[ariellette]

Dynamic !!!! Great work...excellent 3D medical animation..

[mcollin14]

Awesome biology animation

[hpiantek]

This 3D medical animation is a great way to show medical illustration in motion. It's much easier to understand this way.

Fantastic work Nucleus!

[ACEgenetics]

Excellent medical and scientific 3D animation showing macrophage cytokine release Nucleus Medical Art!

[WigglySquid]

Fantastic biology animation!

[rochelimit55555]

i see......

[Gexicon]

спасибо, я никогда этого не видел