Zoya Maslak, Yuri Rashkin - The G Protein Story

[rbcornell]

Sorry - this video is misleading in many aspects. The adenylate cyclase is a transmembrane protein so the synthesis of cAMP occurs on the membrane. The alpha subunit of the G protein is lipidated and diffuses along the inner leaflet of the membrane to contact AC. Lastly the dimensions of the receptor vs the G protein are off-base. The G protein complex is in fact larger than the receptor.

[sylviedroz]

holy shit. i finally understand!

[neenooo91]

if you were only my textbook...

thanks! this is great!

[BennyDeVries]

This is just awesome

[DodoYay]

thaaaaaaanx a lottttt

[ElCaciqueLoco]

Best GPCR video explanation on the net.

[benlichkeit]

not only is adenylate cyclase a transmembraneenzyme, but also does the GalphaGTPcomplex have a lipid anchor that keeps it locked into the plasmamembrane of the cell! Meaning that it DOESN´T float around in the cytoplasma

other then that its a very nice animation

[Sarifacharya]

thank you for this creative and very truly informative vedio.....

[MsNoor1991]

thaaaaaaaaaaaaaaaaaaaaaaaaaaaa­aaaaaaaaaaaaaaaaaaaaanks



[MsNoor1991]

thaaaaaaaaaaaaaaanks



[turnsmurder]

Very well done!

[pirateXhunterXzoro]

awesome video. thank you for posting it

[sweiscool]

Good video, it was very helpful, but I am under the impression that adenylate cyclase is membrane bound.

[tanyanurse04]

fantastic mindblowing animation

[mh2blade]

ruski?

[dennismen12]

ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ­ZZZZZZZZZZZZZZZ.

[kirbohydrate]

BEST VIDEO IVE SEEN

YAYAYAYAYYAYAYAYAYAYAYA....im very excited

[fulanaarvore]

congratulations and many many many thanks

[sunieme]

brilliant

[ranata99]

awesome video!

[wishup0na5tar]

woww i understood it so much better, thank you!

[bennhanny01]

Great animation and explanation too!!!

[elfie6979]

thanks guys!

[arahel]

Beautiful, you guys are great!

[spasmado]

thank u so much, really useful!

[mehrshadpiano]

very nice and understandable . really thanks ..

[meetdrmonica]

great work..awesome

[Gillyann]

thank you

[GameSoH]

nice work!!! :) thx for the heeeelp

[ColonelGeena]

excellent, best GDP animation I found

[stagginator]

It's all so peaceful

[Counterclarity]

Im pretty sure that the alpha subunit is anchored to the plasma membrane, in the same way as the gamma subunit of the heterodimer, so it cant diffuse off into the cytoplasm...

[fifi1314]

FANTASTIC VID!!!!!!!

[smunoz08]

why is the neurotransmisor released again after the process is finished? why does the protein return to the receptor?

[johnpaulgorman]

Well yes and no.....Why does the video show the release of the neuro transmitter (with no explanation), and with GDP rebinding, why does this not trigger the attachment to the receptor (cause it still has the neurotransmitter attached) that would recycle the transduction again ! ... Nice vid, but would be really good if you could fill in the gaps here.

[surfbum188]

yes, how is it that when the GDP rebinds to the receptor the cycle doesn't repeat seeing as the neurotransmitter is still attached, and can only one GTP be released per binding receptor or can multiple ones

[TheYuri]

Thanks!

[mdelcarmenvale]

great!!