bilirubin metabolism made simple

[nvk1001]

outstanding work. thanks

[Jefgg]

There must be a guy somewhere named Billy Rubin.

[praveenathescorpio]

awesome, thanks!

[trame0227]

Thanks

[mwartdt]

conjugated bilirubin is converted into urobilinogen by gut bacteria right? And none is reabsorbed without conversion? Does anyone know how much urobilinogen (%) is reabsorbed into blood and how much is excreted in feces? And from the blood, how much goes back into the liver for recycling and how much is excreted in the urine? Thanks! Can't find the answer anywhere

[nikhilakapatsy]

mdsc 3311 sucks

[alharthy86]

thank you !

[rapabhsi]

thank you this was very helpfuland like to also include: In the intestine, bacterial flora deconjugate and reduce bilirubin to compounds called stercobilinogens .

[bigdaddycuba]

Incredibly useful! Thank you.



[zookybeans]

Good one.

[Allibaby78]

In the liver, it is bound intracellularly to special Y and Z proteins.

UDP glucuronic acid reacts with bilirubin under the influence of the enzyme glucuronyl transferase to form:

mainly bilirubin diglucuronide

minimal bilirubin monoglucuronide, and

UDP

The glucuronide conjugated form of bilirubin is water soluble and hence more suitable for excretion into bile.

Disorders of bilirubin uptake or conjugation can lead to hepatic jaundice.

[Allibaby78]

Uptake by hepatocytes

At the sinusoidal surface of the hepatocyte, bilirubin

dissociates from albumin and is taken up by the hepatocyte

by facilitated diffusion that requires inorganic anions, such as

Cl. The protein(s) involved in sinusoidal bilirubin uptake .

have not been identified. A member of the organic anion transport protein family, termed OATP2 (also termed SLC21A6),

has been proposed as the sinusoidal bilirubin transporter.

[moooony92]

Thank you very much

[aprilish23]

thank you so much for this video :)

[coxsta08]

very very cool. saying that makes me not so cool.

[najatlovesmovies]

thanx

[xxthunderbird46xx]

Can't thank you enough!!

[MsMjjt]

Thank you for this video. It helped me a lot.

[medfinals]

This is brilliant, THANKYOU!

[petedigitaltube]

nice and simple: easy to understand. thanks! a great help to me

[teepot01]

awesome!! thanks alot for ur effort.. how was ur usmle tests? hope u it thru =]

[kungfufighting00]

thanks so much!

[VindictusDame]

oh my god. thank youuuu darling!

[kkaarrllaamd]

this is truly the best explanation I have ever seen. THANKS SO MUCH!

[k847]

very gud job....Bravo

[Muuip]

Thank you very much for posting! Does anyone Know how and why Bilirubin stores itslef in our fat and its effects on our nerves?

When stored under the skin it creates itchiness, why is that?

[KyleVarner]

Nice, this was very helpful!  Thanks!

[civver3]

Answers the question "Why poop is brown".

[hemo656]

thank you,,,

nice and simple explanation

[manzanero05]

Great ¡¡¡ from Spain

[otterboxiphone]

Nice!

[forgottendreams764]

This video helps alot, thank you =]

[415luke]

Very nice work. Thank you.

[annakatloveslife]

tnx! :)

[greeningwsu]

great job!! THank you!!!

[intansafuraa]

wow, thanks for that, but wish the video was clearer tho

[cobo4]

very nice summary

[dhukka123]

Good presentation.

[scvmani]

wow.. great explanation.. the never ending pages of Harrisons all condensed by this easy to understand video!!

[RammsteinAddict26]

oh my god...thank you

I am also reviewing for the USMLE

[wire4me]

@RammsteinAddict26 me too

[tashishiekh]

Good Effort

[tashishiekh]

good effort