sacroplasmic reticulum

[JamieMac007]

Also check out another video i made on the heart function with an equally impresive song choice! (its in the video responses)

[OakIcedancer]

BEAUTIFUL - THANK YOU :)

[zosozox]

@OakIcedancer You're croat, right? hehehehehe... Yes I've heard - croatia is a horrible place with all kinds of discrimination be it racial, cultural, national, social, political, sexual, religious or any other.... I holidayed there last year and every where local people who could speak English didn't stop talking about how they can't wait till they're in the EU so they can get the hell out! Nice, a? hehehehe

[JamieMac007]

If you want sound with accurate annotations please look to the first video response

[ZerayaNF]

@JamieMac007 Hahaha xD can't stop laughing :D nice music :P

[Aleiraw]

Excelente el video--

[PunkinLPN]

I have no sound

[mumptyfish]

it needs sound

[irunmadn]

No sound. : -(

[ctank08]

God is awesome!

[Jatodude1]

Wow. This makes a lot of sense when you can visually understand it before learning all the things that make it work.

[MrLamchopxl71]

damn.. 41 seconds of this video just helped me understand 15 pages of text book.

[thirdbar]

sarcoplasmic reticulum surrounds the filaments, it is what is dispersing the calcium you see there., not really shown here.

[Mewmew1251]

Where is the ATP and ADP?

[grayar78]

I'm sure this video would be even better if it had sound...

[MrEeyan17]

i need to understand this stuff...ANA.PHY

[mrparke007]

The mechanism for how Ca++ moves the troponin-tropomyosin complex is wrong. It slides around actin to reveal the binding site. The position of the myosin heads is also wrong... especially with how they orient to attach to actin.

The video shows calcium raining down (from something...?) and makes it appear as if Ca is causing myosin to move, which it doesn't. It only reveals the binding site for myosin on actin.

The animation for the heart beat is COMPLETELY wrong. Atria first, then ventricles.

[deepintention]

@mrparke007

It does show the atria contracting first...

[Sn0wFreak]

This is stupid it make it look like the myosin heads have a mind of their own and like move around until they find a binding site......in actual fact only the bit on the end of the myosin cross bridge moves....the coil stays still

[ccviol]

Sarcoplasmic reticulum (SR) are "elongated sacs of modified smooth endoplasmic reticulum" (organelles)

SR contains Ca2+ (white dots in video) which is released into the cytoplasm of the cell, where it interacts with proteins on actin filaments. This allows for the process in this video to take place. The SR is not physically connected to the actin & myosin filaments, and is not seen in this video.

In cardiac muscle, the initial Ca2+ required for contraction is from the extracellular environment.

[55582rahul]

Its a bit weird, there's no sound. But its really good coz i could understand most of the stuff without the sound. But why is the title "Sarcoplasmic Reticulum"?? It should have been something like "why does our heart beat?"

[Lonely401]

it should've been, "muscle contaction" or "sliding filament theory"

[Fullmetal392]

@55582rahul because that doesnt explain why our heart beats, that shows muscle contraction with myosin heads pulling across actin to contract. That itself is in a sarcomere which can be any muscle in the body.

[maevey08]

Is there ment to be sound on this video? dere was non when I watched it??? Is it that the calcium comes from the sarcoplasmic reticulum?

[kevinpresley007]

yeah, that's where the Ca2+ comes from. idk this video, no sound or really any good explanation of what's going on. They're not good mention of the action potential that causes the release in the first place.

[cinderdork]

beautiful

[haden555]

My anatomy book sucks ass. This video taught me everything i need to know.

[draxes88]

lol

[jwilillou]

very impressive

[kagebun]

is anyone else ever flabbergasted by this amazing feat?

also, does it ever get people's blood boiling to find out what functions control this calcium snow and what inevitable controls this decision making ability?... kinda scary

[nyxrich]

where the fuck is sarcoplasmic reticulum???

[futrmd]

@nyxrich •The endoplasmic reticulum (makes protein), when it's very smooth its called the SARCOPLASMIC RETICULUM. It is found with in the muscle cell.

[Fullmetal392]

@nyxrich muscles in your body

[leftywefty]

@nyxrich

it is exclusively located in skeletal and cardiac muscle (caveolae is the equivalent in smooth muscle). It contains calcium ions that help power the contraction. The video actually shows the contraction of the sarcomere, doesn't really go into detail on the sarcoplasmic reticulum though.

[cobrabase]

@nyxrich

It's like the endoplasmic reticulum of a muscle cell... I know that there doesn't seem to be much room in those long muscle cells but think of them as tiny elongated sacs inside. So far I've never seen any anatomy textbooks that show them (yet) and it causes a lot of students problems.

[shaned123456]

@nyxrich its just off screen

[tnemelk1]

according to what i understand, the snow of calcium is sprinkled over troponin which opens the tropomyosin covering which allows the binding of myosin to actin. And with the help of ATP, myosin moves the actin towards the center, and in general will contract the entire muscle. thank you.

[egretb]

The title is spelled wrong. It's Sarcoplasmic Reticulum, not sacro.

[nauticapnoy12]

Ca+ binds randomly. The more Ca+ in SR the more chances you have to remove the troponin from the myosin binding site.

[Mheatherette]

yea this was awsome

[sabrine5]

merci

[shantibear]

great without sound, allows thought

[jinpoooo]

HAHA 'allows thought'

[xxsniperdudexx14]

wow i learned more from this 47 second video than i did in 2 hours of textbook time.

[nadaaa12]

thanks alot

this video helps me so much

[ladbohl]

I thought that one part of the cross bridge was an ATP binding site while the other is an actin binding site.

[mayisha22]

the myosine looks so cute b hardworkin too... :-)

[astro84my]

Thanks lot for a good vid. It helps me alot to get clear about text.

[naneko1001]

This is such an awesome vid

It helped me understand what the textbooks were trying to tell me step by step

[RealFan]

Helpful, also showed the function of the titin protein that acts as a spring to push the myosin filaments back after contraction to restart the whole cycle.

[puppychow89]

Oh my god lol even though there is no sound... I just understood this process.. finally!! THANK YOU

[callmesplit]

this was cool and helpful

[cr1stinaro]

I can't listen either.

[jcbrant]

umm, I got no sound...

(and yes, my amazing sound system is on)

[c1dra]

i'm sure you've realized by now that no sound exists :) the vid is still great tho

[erichau728]

LIFE SAVER!!!

Thankyou

[TheGap425]

excellent!

[christirega]

they are calcium ions that bind to the troponin which move the tropomyosin so the actin-myosin binding sites are exposed, which allow for contraction

[Boltterman37]

What are those tiny white things that can be seen at 0.28 leaving?

[CocolutoBeans]

I think it might be Calcium ions.

[naneko1001]

Ca2+ ions

[Brrrap22]

i needed to see this!!

[flyawayfeather]

Wow!

[LisaAAAH1942]

whoaa

[gepao]

nice!

[7Mvolt4]

this was useful, thanx dude!!!

[aeonswife]

Thanks! Really great video

[Kejlina]

i love it!

[Vegetto19]

Wow...

[sergeantpepper21]

Pretty cool!

[maliath]

its real looking! omg LOL!!1