Fluoroquinolones: Mechanisms of Action and Resistance

[ps07857]

Thank you, it makes studying so much easier....

[Xpozethcorupt]

 hope al you people who are "Medical" take a REAL GOOD LOOK at the HEINOUS effects of these drugs ! It's shocking ! If you get your rocks off in excitement at how it works TAKE A LONG LOOK at what it does to people. Its criminal CRIMINAL!!!!! And if you still go ahead using this stuff -- YOU"RE GUILTY and should take whatever the consequences are ! I guess this is exactly why the MAnufacturers don't care AND THEY KNOW and DID KNOW ALL THE TIME. ---EVIL

[GBelair]

Helps me understand a bit more how my life ended because of FQs... The side effects are not rare, rather they are rarely reported by practitioners who blindly disbelieve the fact without full knowledge of the process that occurs in the body.

[magusfire31]

Very nice video. Really helped me understand how Fluoroquinolones work. I am a second year pharmacy student and was referred to this video by my Pharmacotherapy professor during our Infectious Disease module.

[GBelair]

@magusfire31 Do me a favor though, if oen day someone comes to you and reports the life ending side effects of this drug, please listen to them and take them seriously and be sure to report it.

[tarfah21]

Great one!

i've spent hours on understanding the same mechanism through my lecture note, and this vid sums it all up in less than 10 minutes!!

[MrIshaq89]

FANTASTIC VIDEO

[vaibushi]

these videos are really helpful.........keep upoading such videos...thanx

[mehrshadpiano]

Best video ever . it was complete .

[19DNA89]

Thank you...I´m a biochemistry student and know I understood how the replication does occur in the bacterial cells.

[laex114]

Can anyone write what the guy says?... please.. i'm learning english and can't understand what he says... he speaks too fast for me... PLEASE

[MechanismsMedicine]

@laex114 Most of the narrative text is provided in the "Animation Description" section (click on "Show more" link under the video to expand)

[laex114]

@MechanismsMedicine oooh...thanks... haven't noticed

[blackjeffrey1]

@laex114 For bacteria to replicate, they need to duplicate their DNA. As this is helical, and the process separates strands, it gets super coils. These need to be relived by enzymes (DNA gyrase). As they are circular, it ends up as 2 linked rings, that get separated by something similar to DNA gyrase. These involve cutting the DNA and rejoining it. Fluroquinalones act by making the broken DNA-DNA gyrase complex stable, resulting in broken strands, killing the bacteria.

[justcallmegod2]

Wonderfully clarifying animations and explication, thank you :)

[habsyi3]

Got it... yeah.. thanx

[szigorubb]

great vid, keep up the good work!

[Floxiemoxie1]

I wish that were true Spudgun88. Unfortunately it's not. If only it were that simple.

[Spudgun88]

Great video, thank you.

[tinimo11]

i'm a medical student, and i just wanted to say - these are great!

[rahardin]

Thank you! I am currently synthesizing quinolones as a research project and this video has been very helpful in broadening my understanding of the mechanism of action of this family.

[Floxiemoxie1]

It's very sad that so many people have been crippled by these antibiotics. Were you aware that Fluoroquinolones actually cause breaks within the DNA strands? The adverse reactions are horrific.

[Spudgun88]

@Floxiemoxie1 Yeah, if you're a bacterium...

[Floxiemoxie1]

@Spudgun88 I wish that were true Spudgun88. Unfortunately it's not. If only it were that simple.

[moadpt]

Adorable video, thank you so much. Bless.

[MechanismsMedicine]

@moadpt thank you. Your opinion as a physician is particularly valuable.

[sarmad10]

amazing videos by MechanismsMedicine, thanx a lot for uploading these videos

[MechanismsMedicine]

It's really inspiring to receive your positive feedback and thank you for the subscription! We look forward to see you on our channel again.

[Alredublo]

This is a smartly produced video that explains how this class of drugs work, thank you for posting.