Insulin Signaling (Signal Pathways)

[tajiknomi]

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[shawnchong89]

Here is some additional explanation if your studying this for an exam like me: starting at 2:00, the insulin binds to a insulin receptor that has 4 subunits 2 Alpha and 2 beta, the insulin binds to the alpha subunits in the extra cellular matrix that causes a conformational change in the 2 beta subunits, that results in the beta subunit becoming active kinase

[zackboomer]

@shawnchong89 tyrosine kinase then phosphorylates itself, and then tyrosine kinase transfers a phosphoryl group onto a target protein

[shawnchong89]

Here is some additional explanation if your studying this for an exam like me: starting at 2:00, the insulin binds to a insulin receptor that has 4 subunits 2 Alpha and 2 beta, the insulin binds to the alpha subunits in the extra cellular matrix that causes a conformational change in the 2 beta subunits, that results in the beta subunit becoming active kinase

[chewbaccaisnthuman]

even more amazing than the explanation it's the simple fact that this happens

[TheKatKatPower]

simply amazing!! i love your videos!!!

[OpheliaCat8]

great animation, but I had a hard time following the pathway so I could understand it. The pretty animation was more distracting than helpful. 

[MegaMyristica]

thank you

[pickinvidders]

The video seems to show, in fat cells, three glucoses being converted to glycerol to provide the backbone of a single triacyglycerol molecule. Actually glycerol is formed from 1/2 of a glucose, a 3-carbon chunk.

[AZ30099]

This IS AWESOME

[sanjidaislam1]

they made it more complicated!dang!!!

[soulmsg]

hahaa nice one :)

[ebonyamberjade]

Holy crap I do not understand :-/

[bodoification]

Very nice illustration.

transporter for glucose in muscle and adipose tissue is GLUT4, but for brain is GLUT3. There are 12 glucose transporters encoded in the human genome.

[MITHWORLD1]

This is really amazing.

[oxanakoshova]

Really, brain cells do not depend on Glut-4 transporter. Otherwise, the video is good.

[keebearfull]

Same thought as jrg305. Are my brian cells fully or partly dependant on glut4? I think liver and brain cells have other mechanisms that are at least primarily responsible for uptake of insulin. If I'm correct then this video is in error @ 2:15-16.

[keebearfull]

Thanks ND State. Some of the very best on YT.

[chiaraviga]

very nice!

[jrg305]

I thought the brain wasn't dependent on Glut4 transporters...it's one of those tissues that requires glucose and insulin resistance there would mean death or increased use of ketones. Someone enlighten me on my perceived discrepancy.

[amm964]

My goodness...how/why do you guys do this for free? You all have saved me from countless Fs!

[WindInAWheatfield]

they do it for that warm, fuzzy feeling inside

[exoticbeb]

LOLz

[thunderpants10]

wicked cool

[Hooya2]

Nice animation. I was confused a few times due to the language, but the pretty pictures straightened me out.

[dann815]

Beautiful!

[rax2099]

good

[thewordisalive1]

Thanks for all your hard work