The inventor of Omniscan (Steven Quay) & colleagues tell the toxic truth in the article below.
Magnetic Resonance Imaging, Vol. 8, pp. 467-48 1, I990
Release of Gd3+ from the complex is responsible for the toxicity associated with gadoliium complexes; this release appears to be a consequence of Zn2+, Cu2+, and Ca2+ transmetallation in vivo. The added Ca2+ salt of the ligand must have a favorable toxicity so that the decrease in toxicity from in vivo transmetallation is not offset.......
The inventor of Omniscan (Steven Quay) & colleagues tell the toxic truth in the article below.
Magnetic Resonance Imaging, Vol. 8, pp. 467-48 1, I990
Release of Gd3+ from the complex is responsible for the toxicity associated with gadoliium complexes; this release appears to be a consequence of Zn2+, Cu2+, and Ca2+ transmetallation in vivo. The added Ca2+ salt of the ligand must have a favorable toxicity so that the decrease in toxicity from in vivo transmetallation is not offset.......
dreamwvr57 5 months ago