Apoptosis

[ipeklofijs]

A crossbreed of "Begotten", "Dawn of the Dead" and "Toy Story".

[FingerBench]

think ull find this popcorn in its natural habitat

[meadowsirl]

i would love a voiceover on this one.

[diallog1]

Question: What directs the movement of these molecules? Is it all magnetism? And if so why does each molecule only bind to certain other molecules? And how does the caspase 3 cleave proteins? Magnetism?

Generally, how is the complex swimming, walking, binding, seeking, timing, and complex sequencing in cells directed on a molecular level?

[dookiecheez]

Gave me a major horror film vibe. Awesome stuff.

[ashwinnarayanVlog]

This video needs more views.

[toyouiwill]

OK, two cells walk into a bar...

[b14blah]

Great! Thanks for making.

[Quexio]

a conspiracy of events has to occur in order for the cell to die. beautiful

[rycaltor]

This is one of the greatest biology animations I have ever seen. The sound effects and high activity level make it even more appealing. Thanks!

[Croaan12]

ALIEN INVASION...

[Greyhunter123]

For some reason this is really, really scary. Great vid though, really eye opening!

[DevilOnHog]

langoliars

[jenny07la]

molecularmovies. com/showcase/

[paxguerilla]

I LOVE the sound effects! My cells sound just like that, too.

[paxguerilla]

@paxguerilla Now I am afraid of proteins buzzing around killing us all. Death never looked so exciting.

[bemdopey]

mmmmmmhhh nerds <3

[dudecrushdude]

Universes within ourselves O_O

[kepplerh]

i stumbled this video, and i'm no biology enthusiast, but those animations are much better than anything pixar has ever created.

[Essincy]

6) However, a (pro-apoptotic) BAX -vs- BCL2 (anti-apoptotic) balance exists in the cell

7) Upon stimulation, BAX (pro-apoptotic) is both transcriptionally AND directly activated by p53

8) BAX then travels to mitochondrial membrane (aided by CASP2, BID) and oligomerises

9) BAX oligomer now binds to VDAC1 on the outer membrane = cyt c release

10) Cyt c binds APAF1, which binds CASP9, via CARD domain, and forms the apoptosome

11) Apoptosome activate CASP 3/CASP7, which destroy the cell!

[Essincy]

1) Death ligands (TNF-a,TNF-b,TRAIL,apo3) bind to death receptors (DR3,DR4,DR5) on diseased cell surface, via the death-domain (DD).

2) Upon ligand-receptor binding, adaptor proteins (FADD,CRADD,CASP8) are recruited and bind to C-Terminus end of death receptor, via the DD.

3) Following receptor/adaptor engagement, CASP8/CASP10 are recruited and bind via death effector doman (DED).

4) Pro-caspase 8 gets activated by binding to DED,

5) Activated CASP8 activates CASP3/CASP7, which destroy the cell!

[bpcardona]

Great video!!!!!

[MillenniumHealth]

I am writing a book TBI - A clinical Approach to Diagnosis and Treatment. Find me at tbimedlegal and have spent the past 6 weeks reading articles on Apoptosis, Necrosis and Authphagy. Your film is excellent and makes sense. When I return to Melbourne with Pathlabs, I owe you a tall one for the efforts and accomplishment... Excellent work..

[metalebd]

This was like biochemistry in a David Lynch movie. I'm gonna go watch Blue Velvet so I can chill out.

[MegaAlfies]

amazing O_O

[Medicalmarcl]

great video with great sound effects !!

but doesn't show how the CASPASE3 clives ICAD activating CAD and how CAD fragments the cromatine..

[lower2organism]

LIKE A catastrope...amazing!

[GalbertReloaded]

Amazing video, my best compliments to the authors. I highly recommend to watch it while playing the video "Craig Armstrong - Escape (Full Version)" instead of the original audio, it becomes much more emotioning! =]

[agrippaviar]

working on breast cancer i found this video i recommend u this article it was published this year. Zhang, Han-Zhong; Drewe, John; Tseng, Ben; Kasibhatla, Shailaja; Cai, Sui Xiong. Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay. Maxim Pharmaceuticals, Inc., San Diego, CA, USA. Bioorganic & Medicinal Chemistry (2004), 12(13), 3649-3655.

[HUKKAH19]

Nice video. What did you make the animation with?

[wudgee]

I'm studying apoptosis at the moment in my course and having to write at the mo about cascade 8 so this is helpful to visualise things, I love this type of visual aid. Love the animation many thanks.

[Atena212]

Is this apoptosis by membrane receptor? Does exist also apoptosis by inner damage? How many type of apoptosis?

[Elusefelier]

What an amazing video!! Great job.

[gagzy1989]

FAB-U-LOUS!

[RayZR]

I've noticed that there are a few comments here about not understanding what's going on.

Here's the Sparknote's version. Basically it is a cascade of proteins activating other proteins. Eventually, the end product protein breaks down the cytoskeleton of the cell, which determines the cell's rigidity and structure, causing the cell to essentially disintegrate.

[The4LA2Baker0]

that was awesome but I didnt really understand what was going on 1/2 the time.

[mrinedible]

incredible.

[Neopluto]

Should have also labeled "blebbing" lol...

[gavincurtis]

Termination sequence............  activated.

[Vidar33]

An impressive animation, but I guess I don't know enough about cellular biology to know what is going on here.

[achalneupane]

wow