B-Cells 2 - Antibody Production and Recombination

[r0binson2424]

This is so simple now! An excellent tutorial i wish you were my lecturer!! Thanks

[regnlong]

The instructor claims that IgG expression results from splicing out the M and D constant regions in the mRNA. This is completely incorrect. IgG expression results from a DNA recombination event, which deletes the intervening M and D constant regions and positions the IgG constant region downstream of the VDJ exon.

[regnlong]

Things went completely wrong at the 7:45 mark. Expression of different heavy chain isotypes (IgM, IgG, IgE, etc) is NOT regulated through mRNA splicing. Isotype expression is regulated by a process known as "class switch recombination", which is another DNA recombination event.

[666satanluvr]

Mother of god! thank you for that brilliantly explained lesson

[tomomi404]

Very nice tutorial.... THANK you !!!

[drhasan13]

many thanx for a wonderful tutorial

[sengsakara]

another great tutorial. thank you!!