DNA Transcription and Protein Assembly

[CPYami08]

Helicase unwinds the DNA. RNA polymerase transcribes the DNA to mRNA. Ribosomes are ribozymes (enzyme that is a protein and rRNA complex) that translate the mRNA to protein. Ligase is used in DNA repair, for example, and it ligates the broken peices of DNA back together.

[farmboy575]

@ArsenicBlackgammon the "molecular machine" that unwinds the DNA is an enzyme called DNA Ligase

[farmboy575]

@farmboy575 my mistake- DNA helicase unwinds the DNA

[TheLadyB57]

i love it..it's great

[OwSpamHam]

0:52 nomnomnom..

[ayahahmad00]

Amazing one >>> gamda gamda gamda mooot :)))

thanks alot .......

[iluvmyhorse105]

@ArsenicBlackgammon "A molecular machine..." is the enzyme that unwinds the DNA. And that's all I know, sorry!

[filip3374]

star wars

[cuongbach520]

GIVE ME THE FKING NAME OF THOSE MACHINE THAT U MENTION ,PLEASE

[Eminicrispy]

Wow, if only they replaced the word machine this would actually be insightful.

[jossawnn]

This is amazing! So freakin cool! Been watching this all day and can't simply stop!!! WOW A+

[panantono]

Machines do everything these days

[honigmusic]

eric+melanie 4ever

[TheWaluigiman1]

Science is beautiful.

[sarahmargaret27]

when he says machine.. I'm assuming he's talking about enzymes?

[tricky12321]

@sarahmargaret27 The first one is DNA helicase - it breaks the hydrogen bonds

The second one is RNA polymerase in protein synthesis but its in DNA replication as well and thats called DNA polymerase - simply because in protein synthesis it makes RNA and in DNA rep the end product is two new DNA strands

[WutEverIFeel]

The "machines" are enzymes and one of them is a ribosome. I watched the video to learn the name of these machines!!!!

[Wilsondano1]

As our brave young DNAs embark on the adventure of their life, they say their goodbyes to their families as they may never return home.

*Que epic music*

[Pswmi666]

I think I'm watching star wars...

[swimfreakon]

@PerryCS2 yah I don't get how this could just randomly happen either... I mean seriously it's insane how complicated this is. And it has to ALWAYS be perfect! Totally blows my mind...

[blaisingm]

@swimfreakon " And it has to ALWAYS be perfect! "

Actually, it makes mistakes all the time. DNA replication, translation and transcription is FAR from perfect. 

[piervasil]

@blaisingm In addition, there are many mechanisms that reduces the gravity of mistakes or correct them. And even with those, there are still mistakes...

[ArsenicBlackgammon]

"A molecular machine..."

"Another Machine"

"When the chain is finished it is moved from the ribosome into a barrelled shaped machine..."

"It is released and then shepherded by another molecular machine-"

I love this overdramatic music, but what is up with calling everything a 'machine'?

[dgilaaa]

@ArsenicBlackgammon They call them machines, because that's what they are, machines made with big molecules that work using electro-magnetic interactions.

[ByRecentDesign]

@ArsenicBlackgammon They are actually machines that do physical work. They have actuall moving parts and everything.

[superbizee1]

Great video. It became soo clear.

[jarallah45]

سبحان الله

[Violetnight8]

Good animation less the satisfactory explanation, far to simple

[MimosaH15]

i hate biology so much right now.

[lewisbreland]

This reminds me of star wars.

[xPray2die2dayx]

can someone please list the machines?

[xPray2die2dayx]

@sockiethesock im in Microbiology bitch! and its like honors biology times 7

[sockiethesock]

@xPray2die2dayx I'm in college bio....

[xPray2die2dayx]

@sockiethesock cool that must be hard eh?

[sockiethesock]

@xPray2die2dayx counting down the days until the semester is over... I hate that class so much right now......

[dkjm84]

Thanks!

[ccfishinguru]

Thumbs up if you think the music is really epic at the end

[PerryCS2]

The human body is so complicated I don't see how it could have ever have evolved... this is but 1 tiny tiny tiny piece of what goes on inside your body.

It's maddening, and scary. Neurons, chemicals, building protein machines, rna, transscription, self destruct, trillions of possibilities... and yet - here we are...

I find everything too perfect, too sureal. Atoms are just right. The universe is too perfect in it's chaos. Scary and sureal...

[hahs4]

after 2 years this video is still helping me

[RichNel1]

Yup

[kevcification]

found this really useful...thanks for posting....

[thebeatles41001]

honestly, this music is so epic that its distracting 

[rockguyjw]

machine at the end = vesicle

[josh32jacobs]

"Machines" haha why go through all the trouble of making this video legit if your going to dumb it down and call known enzymes "machines".

[tuts333]

imma need this to be a bit more specific the machines are helicases!! hello I'm trying to pass a TEST HERE! =D

[hatchcode]

-sigh- I better pass that test!!

[katieannekay]

the epic music makes this seem so much better

[MrDoublet1998]

Anyone notice the epic music?

[WickedPotterHead]

this makes my homework make so much more sense :)

[Aelfredus26]

Need help! Is that 'Barrel shaped machine' a Chaperone/Chaperonine?

[azura2411]

@Aelfredus26 yup it is a chaperone

[skmarx]

All natural organisms do act like this. That's the point. What natural organisms are u talking about?

[zoeybrookes101123]

@TheSystemInsanity AMEN ALL THE WAY!!!!!!! God is an AMAZING God to have fearfully and wonderfully made us in this spectacular way!!!!!!!

[sexynerd34]

that was very cool and totally helped me sound like a genious in my bio class thnx

[ericskimchiddong]

wtf is up with this music, they think the DNAs are heros or something

[christy17ful]

@ericskimchiddong hahaha

[AdrianlovesAerosmith]

@ericskimchiddong

they were but then they took an arrow to the knee

[Tl82T]

@AdrianlovesAerosmith WTF this is not skyrim, this is TRANSCRIPTION AND TRANSLATION!

[xDoctorWho]

@ericskimchiddong They are heros. You wouldn't be alive without it.

[ericskimchiddong]

@xDoctorWho Fucking. Genius.

[XxiiPrODiGYxX]

@ericskimchiddong yea duh

[Mrchalupa1]

@XxiiPrODiGYxX hi carlos :P



[XxiiPrODiGYxX]

@Mrchalupa1 hello :D

[Mrchalupa1]

@ericskimchiddong suck my dick +P

[ericskimchiddong]

@Mrchalupa1 only if its black

[flyonthewall95]

@ericskimchiddong They are heroes :P

[TechnologyGod]

@ericskimchiddong They are! They are the reason for everything you perceive, and everything that has ever lived to perceive it, existing.

[Texcentric]

@ericskimchiddong Where would you be without DNA? Geez, no gratitude with today's generation.

[ericskimchiddong]

@Texcentric Cool

[TheSystemInsanity]

This cannot occur from natural things... this all was first created by God. NO NATURAL organism can do this, this is clearly made by God. How..i mean how can still disbelievers not believe in God after all this facts?!

[sharves]

@TheSystemInsanity the fact that we were 'created' by the mechanism that was shown in video which is not god unless you consider the DNA and it's related mechanisms as your god..

[dwilmer7]

"DNA: storehouses with the instructions necessary to build every protein for an orgasm" I love DNA!!!

[bigwillchill]

rna polymerase is the thing unwinding the dna and makes the mrna strand. mrna travels to the ribosomes in the cytoplasm. the trna bring the amino acids forming a peptide bond between them ultimately making a series of amino acid polypeptide chains which are proteins that will be made specifically to serve a certain purpose in the body . . . easy

[genghis036]

even I think names would make this video perfect

[TheWilly95]

Interesting!

[tessyta]

great video and yes I wish too he names the machines =(

[rdbtwnthlns]

it was definitely organism.

[TheYabbayabba]

lol, im doing a speech about transcription and dna replication, in grade six.

[nflhester3]

@TheYabbayabba LOL is right

[TheYabbayabba]

@nflhester3 i got full marks for it, and im going to public speaking comp.

[gabymm1]

way too basic

[MrGboof]

GOD iS GREAT, we are fearfully and wonderfully made, WHO can search out the wisdomof his understanding!!!!!!!!!!!!!!!!!

[iancmcintyre]

@MrGboof What's really wonderful is how GOD had NOTHING to do with the creation of DNA (nor anything else for that manner). Nature is amazing!

[joshlazarus]

@MrGboof Sorry buddy, but this has nothing to do with God.

[pickthisgirl]

This was beautiful, but I agree, too vague. Why not just name the "machinary"? But I guess it was a good "general knowledge" video.

[TheMordyS]

epic music

[virtual23885]

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[dragonbabyx3]

wish they could make this more interesting!!!!!!!



[MonicaKn17]

What's with the barrel shaped thing? I though the proteins folded themselves up as they exited the ribosome?

[ReikoNemo]

@MonicaKn17 The barrel shaped thing is a chaperone protein.

[riotofone11]

it would be awesome if they named the "molecular machines" that were illustrated. I feel as though all the great animation work was not as incredible because much of the terminology was left out.

[Edward20691]

So fucking beautiful *-*

[iceymanjack]

sometimes i think the music is louder than the speaker

[brownsugarbabe0823]

i sat for hours trying to understand this process in my textbook and now it seems all too easy to understand just within 3 mins and 2 seconds. damn it my textbook needs a movie edition!!

[TheOmnomatopeia]

I swear at 0:30 he says orgasm. I'm not trying to be immature, I keep listening to it and that's what I hear.

[brownsugarbabe0823]

@TheOmnomatopeia na he definitely said organism lol

[Psychomatician]

and we are supposed to believe this all happend by chance. well i got a question for them. how did the ribosome evolve? check mate

[brownsugarbabe0823]

@Psychomatician damn right!!

[RichtoffenRoach]

AMAZING!

[menachem700]

i did not know my balls were amino acids!! 2:36

[Gabeusumaki4]

sound too simple!

[SecondEditions]

한글로 자막된거 잇으면 좋겠다 ㅠ 좋은영상이네요 ㅋㅋ

[TheBobsmithers]

@SecondEditions This sentence needs to undergo translation :P

[84islandgirl]

I wish the "machines" were named in this video. You have to have read about DNA transcription and translation to fully understand the video.

[KamikazeKumquat547]

@84islandgirl Don't expect to get everything in one place. This is a supplementary video.

[vandj2886]

I LOVE the unnecessarily epic music!

[somersaultjuggernaut]

cool mussic



[elvegaro]

I don't think this is strictly 'in line' with current understanding. The DNA does not melt (split) outside of the RNA polymerase, but only in a small transcription bubble WITHIN the polymerase enzyme.

Also, the chaperone proteins do not ALWAYS used, only for some proteins which cannot be folded correctly without the shielding from the environment provided by the chaperone.

[Sonictunic]

Aha!

[weurRTG]

What we need is a scientific illustrator who is willing to keep the details necessary for learning, but can keep the instruction pretty entertaining (i.e. with background music).

[xoxoRiverTamxoxo]

I watched a different video that said the protein is folded as it ejected from the ribosome. It didn't mention a specific folding thing. Could someone please tell me which is correct? D:

This video is very helpful, thank you :)

[hydecker]

thanks for posting a video that is simple enough to show to 4th and 5th graders. I look around and everything elts was more complicated then this. thanks a lot

[ejensenmd]

The people that think this is helpful must be in elementary school because this is so basic that it can't help at all.

[kallie17100]

this is suuuper helpful!

[TefinhaCullen]

Sorry for the mistakes. My computer done something that transformed the word "helped" in that ugly word that i have no idea what mean.

[TefinhaCullen]

It was amazing! This animatiom Telles me with Biology!

[lax22bball]

0:30 ... he definitely says orgasm.

[wattcoffee]

@lax22bball lol

[MyRaven11]

@lax22bball uhmm..he definitly said ORGANISM

[barboriukstis]

I wonder how it'd be in 3D..

[fini52]

@barboriukstis itd be like BAM i have some phenylalanine flying at my face!

hafta say the music was probably cooler than the video...

[Demonplayer999492]

2:28 - 2:47 KATAMARI!!!!!!!!! :)

[mmurus]

excellent video!!! very usefull and clearly! thanks!

[SnowBoardNative]

...Very Basic & very good

[hahs4]

this is the best dna video

[vniekje]

Great! But where is the information? The 'thing' .. and the machine.

Please name it, so its really usefull.

[andrylj11]

What is the barrel shaped organelle?

[Treckorz]

Science proves evolution theory is a bucket of bull.

[kiril692000]

This is like star wars, with nucleotides and transcription complexes

[therealgaga8]

loved this! left out some details... but VERY good for quick reveiw! :) hahaha, I couldnt stop thinking how much the DNA strand looked like a NERDS ROPE :P lol

[angelakachick101]

Thanks for uploading this!

CAN SOMEONE PLEASE TELL ME WHAT RNA IS?!?!?! =S

[brummiebetty1989]

@angelakachick101 ribonucleic acid; basically it is the form of a message between DNA (deoxyribonucleic acid) and protein (which are made up of amino acids).

[ed4grapes]

nice animation but leaves out many details, good for high school not enough for college

[plumbob949]

@ed4grapes for me this isn't even good enough for high school bio. i can't get away with saying "molecular machine" or anything like that. its good for basic comprehension though

[SuperAppah]

this was not helpful at all, if they actually used the official terms instead of ''machine'' this might have been helpful

[naddogg89]

@SuperAppah Hahahahaha

[brummiebetty1989]

@SuperAppah There are other videos with more detail about each "machine".

I feel this is a good starting point.

[Falasi21]

Thanks alot this helped me in my bio test =D

[whiteoleandification]

Better than Star Wars XD

[nicolemar196]

THIS HELPED ME SO MUCH<3

BIO TEST WOOOT

[darius41]

This video really helped

[GYS916]

biology test tomorrow , this helps a lot :)

[imaballababy]

Disney world :)

[reesespiece100]

BIOLOGGYY 3RD PERIODDD YEAHHHHHHHHHH....

[dave55s]

shite video! didnt help at all

[Chaos23x]

...Morgan Freeman is that you?!

[guanineboy]

LOVE THIS VIDEO!!!! yayy guanine!!!!

[TheAPPC]

The music is a classic, it`s like describing the the formation of RNA as some sort of "epic adventure" it`s absolutely LMFAO!!! XD

[Designmimetics]

Amazing!! Also FYI this footage is from an Intelligent Design documentary called "Unlocking the Mystery of Life". Eugenie Scott of the NCSE should be emailed this clip haha. And really 28 dislikes?? What is there to dislike about the clip?? Must be anti-ID pple who are livid by the fact that this popular clip explaining DNA and its workings are from a PRO ID documentary.

[NeciFiX2]

@Designmimetics How does this, at all, suggest ID?

[lovelyday713]

I love this video! I think it's amazing.  What program did you use to create it?

[Designmimetics]

@lovelyday713 It's from the documentary "Unlocking the Mystery of Life". A Intelligent Design documentary which can be seen on youtube

[Sadoda777]

I have a question. What happens to RNA after it is used by ribosome???

[TheAPPC]

@Sadoda777 The RNA quickly breaks down in the cytoplasm of the cell.

[beestats14]

great video

[beestats14]

great video

[Snousage]

Goddammit being a nerd is so awesome!!! I can get used to this nerd-business

[mar1249]

..... poco sabemos de nuestra tierra. Mario

[msmclendon1]

testicles at 2:35

[takovarra]

what is the barrel shaped machine called?

[abodxox]

bilogy lessons are only perfectly understandable with animation videos like these.

[ashwinbhat123]

This sounds simplistic, DNA is just a chemical, how does a chemical move in such a specific fashion that it is transcribed and the RNA produced, how does that RNA know where to go, and that too to fit inside a tiny pore of the nucleus! remember these arent living things, but inanimate chemicals.

[Exception88]

I'd guess physics. Electromagnetic forces. Which all boils down to math.

[ashwinbhat123]

@Exception88 well we are talking abt inanimate chemicals doing very precise stuff here, RNA go out of the nucleus not here and go over there and then u will find rhobosomes which snag it and the amino acids needed to make protein they all arrive when needed at that sequence. That is truly mindboggling if it was just electromagnetics doing that every single time billions of times.

[HaloPCVault]

@ashwinbhat123

Great questions indeed!

The video was very simple, which is great. It could have helped if there had been a mention of the anticodons or codons, and uracil rather than thymine. Very nice animation though, got the basic concepts of transcription and translation through.

[undressplease]

Lol this is so wrong. don't make these videos, you're just confusing people.

[justinbieberox57]

very helpful

[cityxtopxlights]

well apart from not naming the "machines" (ie: rna ploymerase, ribosomal subunits, the spliceosomes, etc.) the animation was cool.