I've had morphine once, after a motorcycle crash where I broke my pelvis, thumb, and separated my shoulder. I was worried about the effects so I refused it in the ambulance, but in the emergency room the doctor insisted I have it. It helped a bit with the pain, but my god, I became so nauseous and bitterly unhappy about the situation. It wasn't worth it, I'd have been better off with a way lesser drug. Threw up repeatedly, and let me tell you, throwing up is hard when your body is broken.
@aluisious Really? I'm surprised they didn't give you Promethazine for the nausea. I've never had the nausea associated with Morphene or other opiates, I have had "very" slight skin itchiness but only in higher doses.
Actually codeine withdrawal seems to be far worse from what I've heard from the few junkies who managed to take it long enough (strange that it's possible with its ceiling effect). Also codeine (not in itself) is more active than originally thought to be. Not because of the minor conversion to morphine but through C6G (codeine-6-glucoronate).
Diamorphine is interesting because it only has a in vivo halflife of a few seconds. The monoacetyl (6-MAM) has a few minutes.
Everyone talks about what it does to your brain, or how we don't understand how it works, or that it kills brain cells or activates 'dormant' areas or whatever. Please explain it!
Just a small correction: the name Heroin is not "street slang," but it was a brand name given to that drug by bayer, who tried to sell it as a cough medicine of all things...
@periodicvideos Brilliant video. I'd like to see a video about Tramadol, as I moved from being on morphine while in hospital to spending a couple of weeks on Tramadol at home (they don't send you home with morphine!) The profuse sweating and withdrawal symptoms were pretty awful.
Word to the wise, kids - Don't take prescription medication unless it's absolutely necessary. Even if you're in hospital it can pay to say, "no thank you". Cannabis and opiates are VERY different things.
Can you do a video on DDT please. I have heard that it is not nearly as toxic as earlier literature would suggest. It remains one of a very few chemicals in the fight against malaria.
@oomblikkies you actually wrong, ddt is extremely dangerous chemical as it accumulates and last very long witihin ecosystem, poisoning many different animals and inhibiting reproduction. ddt is not nearly as safe as some interest groups want you to believe. in the fight against malaria there are better and more effective ways, take the lesson from borneo
HI! Thanks for posting videos like these. They're especially useful to pharmacy students just like me! =D Your videos have given me a greater appreciation for chemistry. THANKS! =D
From the poppy seed pod, mostly. The opiates are also in the seeds, but they are harvested by cutting the seed pod and collecting the sap which exudes.
Thanks for the great video :) It would be great if you could make a video explaining the processes through which opiate users gain a tolerance and physical addiction.
Can you do a video on HOW these molecules are actually made? How does science isolate them, do they stack them on a molecule shelf? How do they "bond" the bits together, what's the glue of molecular biology and how do scientists do it?
I'm autistic and opiates do an amazing job at quelling the constant, throbbing psychological pain I feel on a daily basis due to my illness. Psychological and physical pain are mediated by the same neural circuitry, so I'm just as justified as a cancer patient in my self-medication.
Ketamine is used in emergency medicine where morphine is not enough. Any chance of a video on that? Would be quite interesting as it is also used as a horse tranquiliser and recreationally by "the kids". Those crazy kids...
please create a video about how to create new chemical connections like "improving morphine". Do people start with a virtual computer design and then put atom next to atom using an electrone microscope - i doubt that.
@AlexBesogonov In all fairness he later goes on to mention that dia-morphine is stronger aswell, i think it was more of a spur of the moment excitement thing. However yes there are plenty of analgesics which are more active than morphine.
@AlexBesogonov That reflects only the dosage you need to use, not the real effectiveness of relieving the pain. As far as I know, morphine indeed is the best.
After seeing the video on aspirin I can't help but notice that aspirin's activity is partly based on an acetate group as well. might this have anything to do with why heroin is more active?
@japanesepoptart yes, but heroin i still considered stronger becouse of this charatheristics, it does not only pass through blood-brain barrier easily it also passes through all those structers inside the brain makeing it much more easily to distribute through-out the brain
Hello, I just wanted to say I'm a huge fan of your videos.. As a medical student, I was thinking: maybe you could do a medical channel, like sixtysymbols for physics? It would be great and interesting for people to learn about their own bodies and at the same time it could counteract antivaccination movements and alternative medicines that form due to a lack of general understanding of modern medicine. Medicine is also a good example of application of many branches of science!
The raw material for natural ore semisynthetic opiates are mainly from lagal poopy fields in India. The instability in the Afghaninstan region doesn't really affect the medicinal supply of raw opium.
This comment has received too many negative votesshow
The interviewer asked, "Have you ever been unlucky enough to meet Morphine?" His choice of words is a bit ignorant. Ask anyone who's been in severe pain; they wouldn't consider themselves unlucky for a drug to be available to help them. Just ask any woman in labor. Society has given the opiates a bad rap.
@ajcusn you don't need me to tell you how pedantic you're being...
If I'd said "Have you ever been LUCKY enough to have morphine?" someone else would have written that you're hardly lucky to be in such pain in the first place... Overall surely the luckier person is he or she who is not suffering at all.
Anti-cancer drugs are great, but I still feel it would be appropriate to say someone with cancer has suffered a misfortune.
And I don't think this video gives morphine a bad rap! :)
@periodicvideos No, having morphine is lucky. Having pain resulting in you needing morphine, that sucks. But getting morphine in and of itself, particularly getting it either whilst you're in no pain, or whilst you're withdrawing from it, is like being wrapped in God's warmest blanket...so yes it is a lucky thing indeed
Yes, being able to have morphine in a bad situation is good.
But, I've yet to meet the person who would rather be in extreme pain and then take morphine, than not be in pain to begin with. As they said too, morphine has some nasty side effects: I've never taken it myself, but I heard that it makes your head feel like a huge lead brick.
@japanesepoptart That's not what I meant. Being in a normal situation and having morphine is awesome, because (in my first-hand experience) it feels like pure concentrated bliss moving through your bloodstream...being in a bad situation sucks no matter what, whether you have morphine or not. I only meant that having morphine is great, because being on it feels awesome. Being in pain is not necessarily a prerequisite to being on morphine. Although if you're getting it because you're in pain..
I suppose. But I think they were implying being in pain. Anyway, if you really get technical about it, having morphine exist in this world is probably a good thing. The opioid family is very vast and contains many different chemicals like morphine, codeine, heroin, hydrocodone, and oxycodone. All of which have many different uses ranging from minor pain, to the most severe pain in your life. Actually, my neighbor is taking Vicodin right now to help him with his broken ribs.
@japanesepoptart that,makes you constipated as hell,slows your digestion, habitual use will make you fat,will make you sweat profusely,can give you massive massive gut wrenching headaches if you have a intolerance to it (first hand experience on all counts).and its also a bitch to get off of!
Really? huh. well, they didn't want to give my neighbor a brace because he's old and has a higher chance of getting pneumonia. so they just gave him vicodin and said to not engage in a lot of physical activity for a year.
@periodicvideos Had Morphine, was wired up to a huge wonkin' tube of it once after major surgery. Absolutely no effect what so ever. Pethadine however, that was nice but not as nice as you'd think.
@DrBones666 I spent a week on morphine after an operation and I agree that it's difficult to tell if it's having any effect, going straight from the operating theatre to being on morphine. The psychological effects are also quite subtle. However, due to a faulty machine I was without morphine for a night, and very early the next morning I awoke in absolute agony. I cannot express the pain that I felt. So morphine was actually having a very strong effect - enough to make me feel nothing at all.
@nagualdesign I hear what you are saying. In my case though, I pushed the delivery button as much as I could, then the next day didn't push it at all. No difference. Then I told them to disconnect me. They came in, tested it to make sure it was actually delivering the substance into my IV. It was. Disconnected me. Next day, no difference. There was pain, I'd been in surgery for 13 hours and had all my intestines re-routed and re-hung but there was just no difference. Who knows.
@DrBones666 The big syringe contains very dilute morphine. One press of the button delivers a 1mg dose. If you press the button every 5 minutes (the maximum the machine allows), as I ended up doing too, you quickly build up a tolerance. As the pain was getting worse I complained that the machine wasn't working and they upped the dose to 1.5mg, which worked fine. People have very different perceptions of pain, and sometimes the most gruesome operations are the quickest to recover from.
"How are painkillers different from neurotoxins?"
the two words are general terms. in otherwords, a painkiller KILLS PAIN. and a neurotoxin is TOXIC to NEURO processes. example. if u injest opium then it can be a pain killer but if u injest enough opium then it can be toxic to neuro signals like the ones that make you breath or like ur heartbeat. as a sidenote, some painkillers cannot be neurotoxic although they might kill u other ways; and some neutotoxics are not painkillers.
"Where do you get the stuff to make those molecule models? I want some"
search "wikipedia molecular model". at bottom of page there is one section showing computer software so u can make models on your computer. and another section has lists where u can buy model kits.
"Where do you get the stuff to make those molecule models? I want some"
search "wikipedia molecular model". at bottom of their page there is one section showing computer software so u can make models on your computer. and another section has lists where u can buy model kits.
also at periodicvideos, the Seeds of the poppy is not where they commercially extract the alkaloids; harvesting equipment gathers the entire plant. although, re seeds, some species' seeds do contain some alkaloids (contrary to what u will read on some gov websites).
at 1:00 it says 'for some reason the poppies in afghanistan and pakistan grow stronger'...the reason for variance in poppy strength is because there is many Types Of opium poppy. the somniferum species has many sub-species and then within those sub-species there is other sub-groups. total alkaloid content can vary from 1% to 17%.
@Brudof There is no scientific proof that DMT is generated in the pineal gland, it's really a theory from one scientist (Rick Strassman) that was never proven, and was, for some reason, happily adopted by new age, parapsychology and psychedelics enthusiasts. It's a myth, and doing a bit of research through journals and papers will prove it.
3-Methylmorphine is Codeine whereas 6-Methylmorphine is "Oripavine", one of the alkaloids of the Oriental Poppy (P. orientalis and P. bracteatum). It is interesting how 3,6-Diacetylmorphine is a slightly more potent analgesic than morphine whereas 3,6-Dimethylmorphine would produce side effects similar to Strychnine. That one would be "Thebaine", an alkaloid from which oxycodone, oxymorphone, and etorphine are derived from.The last one being appx. 1,000-3,000 stronger than morphine. Interesting
--6-methylmorphine is not oripavine. There's an extra degree of unsaturation on oripavine, so the 14 carbon is not quaternary. This is not trivial cuz it changes the shape and flexibility of the molecule, and I suspect oripavine's toxicity is due to the extra rigidity at the 14 carbon.
--For the same reason, 3,6-dimethylmorphine is not thebaine.
--Incidentally, "6-methylmorphine" is known as heterocodeine, and is 6 times stronger than morphine!
@opiumgland Thank you for correcting me on this. I was using the 9th and 10th edition of the Merck Index and a few JACA as the source, but those were from the mid-1950's and I did not have anything which suggested to me about the shape and flexibility of oripavine's molecule. This is interesting and I don't mind the catching up I have to do. I looked again at the molecules and yes, I didn't see the difference before at the C-14 position, but now I do. Thank you for correcting me. :)
Woah, interesting how close all these molecules are to eachother. Now, I have a question, I can not take codeine because I will get knocked out and have a short period of amnesia after that, does that mean I can not take morphine either? I would then have to notify medical personal when I need to be taken to the hospital, when ever needed.
im allergic to morphine... when i was 5 years old i was in the hospital for 2 broken wrists. they give me morphine to stop the pain and i turned purple and got hives all over and passed out.
@Bimm3rcc sodium borohydride doesn't cleave ethers I don't think; normally ethers are cleaved by refluxing in concentrated HBr, but this will not convert codeine to morphine because both codeine's ethers would be cleaved.
The laboratory reagent often used to convert codeine to morphine is pyridine HCl. Rhodium has a "home bake" procedure for this but I'm told it's low yield.
@rifleman1002 it´s the beauty of the free expression world as is in this quote attributed to Voltaire "I disapprove of what you say, but I will defend to the death your right to say it." peace Lo
The most acute pain I had, turned out to be a blocked and infected sinus! Diagnosed as a root canal problem and after an hour of drilling and packing and filling at a dentists! I was crying with pain! Antibiotics sorted the pain after 2 two days. Meanwhile I took codeine pills.
The worst pain I've ever had was a knee in the groin when in school. I got no sympathy from the female teacher that came along, in fact she was pretty rude about it. "Get up off the ground" she said, "you're blocking the queue." "FUCK OFF!" First and only time I ever swore at a teacher but as soon as I did I think she understood because I didn't get in trouble for it.
@Craydon lol you dont become a junkie. stop listening to what your 3rd grade teacher told you in health class, pot is harmless, i let my kids some it.
@eLLriDe420 If you're giving your kids pot then that's all the evidence I need to say it does major harm, that or you're just a idiot stoned or sober.
@Craydon Codeine is an awful choice of painkiller. The codeine itself has little effect on pain, but can cause nausea etc. To kill pain, it must be converted into morphine by enzymes in your liver. 7% of ppl lack the necessary liver enzyme (CYP2D6) for this conversion. They will feel little or no pain relief, but still get the unpleasant side effects. IF this is your problem, switching to a different opiate should work - maybe vicodin?
p.s. cocaine in solution is the BEST fix for toothache!
it IS quite possible to get high from cocaine in solution, it is how cocaine is able to pass through mucus membranes in the nose; so to use as a local anesthetic u would want to control the Amount Of the cocaine in the solution..also the Type of Solution u use will matter
@WarEqualsPeace That view is being challenged: that CYP2D6 is essential to the activation of codeine. There is evidence that the major active metabolite of codeine is not morphine but C6G (the 6-glucuronide ether of codeine).
Of course, inducing CYP2D6 certainly doesn't hurt codeine's efficacy ;)
@opiumgland Thanks for the info update! I haven't studied this stuff in earnest for close to ten years so I've missed a lot. I'll definitely look into this.
it is a common side-effect to experience nausea with some opiate products, especially when someone is using for the first time. one possible way to get around it is to use very little the first time or two so later the body will be used to it.
@CakesPix It doesn't really matter, ok yes it sucked to be that sick, but codeine didn't relieve any pain at all for me so there's no point in ever taking any again.
"it doesn't really matter, ok yes it sucked to be that sick, but codeine didn't relieve any pain at all for me so there's no point in ever taking any again."
just fyi, codeine is the mildest version of opium so maybe its best if it isnt used as ultimate test. also, some conditions require a muscle relaxant to accompany the pain killer (example ULTRAM).
re the initial nausea u spoke of, be aware it can (also) occur if u take just 1 or 2 pills too many
ps-to elaborate on the nausea issue. nausea can occur if your liver is already maxed-out by other drugs/substances. example, if u take treatment of other type(s) but Then took codeine; the extra load on the liver can make u ill, like a hangover can occur with alcohol. usually doctors perform periodic liver blood test because byproducts can build up and become fatal. fyi, not all drugs accumulate in the liver, some accumulate other places.
The name Heroin was made by Bayer when it was marketed toward women and children against sore throat. Would supposedly make you feel like a Heroin (female hero.)
I'm dumb, what's THC? Also what's bad with smoking? LOL
MindSeeR666 16 hours ago
sounds a bit like the poppy wars...
6sIXisIXs9 4 days ago
Sheesh, when I had several of my teeth removed they gave me Ibuprofen 400/800mg & told me to "sleep it off"
madjimms 1 week ago
Would love a video about nicotine!, I'm a former smoker and would like to know a little more about that little devil of a molecule.
tapelegs 1 week ago
Trainspotting, what a film. Great video!
zanders247 1 week ago
you've just caught the attention of a bunch of druggies now
sedwarg 1 week ago
DELTA-9-TETRAHYDROCANNABINOL!?!?!?!?!
daspense 3 weeks ago
Do LSD! Albert Hoffman!!!
knockdoun 3 weeks ago 2
I forgot about Trainspotting. Great movie
Morophin3 3 weeks ago in playlist Molecular Videos (supported by Aldrich Chemistry)
I've had morphine once, after a motorcycle crash where I broke my pelvis, thumb, and separated my shoulder. I was worried about the effects so I refused it in the ambulance, but in the emergency room the doctor insisted I have it. It helped a bit with the pain, but my god, I became so nauseous and bitterly unhappy about the situation. It wasn't worth it, I'd have been better off with a way lesser drug. Threw up repeatedly, and let me tell you, throwing up is hard when your body is broken.
aluisious 1 month ago
@aluisious Probably because you were beaten up as fuck and in a negative mindset towards it. Morphine is fucking awesome.
davothebum2201 1 week ago
@aluisious Really? I'm surprised they didn't give you Promethazine for the nausea. I've never had the nausea associated with Morphene or other opiates, I have had "very" slight skin itchiness but only in higher doses.
madjimms 1 week ago
You forgot to mention the brain-melting euphoria
FriendofWander 1 month ago
@FriendofWander If your bones are all bashed to bits, you don't really notice any euphoria.
aluisious 1 month ago
Do one on Benzodiazepines.
achemachew 1 month ago
Actually codeine withdrawal seems to be far worse from what I've heard from the few junkies who managed to take it long enough (strange that it's possible with its ceiling effect). Also codeine (not in itself) is more active than originally thought to be. Not because of the minor conversion to morphine but through C6G (codeine-6-glucoronate).
Diamorphine is interesting because it only has a in vivo halflife of a few seconds. The monoacetyl (6-MAM) has a few minutes.
LordMegatherium 1 month ago
Typical... they do a single video on a recreational drug and suddenly the comments are full of requests for other drugs.
But yes, I would be interested in them too xD
MrSkinnyBill 1 month ago 2
Acid, please. Lysergic acid diethylamide. LSD.
Everyone talks about what it does to your brain, or how we don't understand how it works, or that it kills brain cells or activates 'dormant' areas or whatever. Please explain it!
JossJossJoss1 2 months ago
not all opiates come from the poppy, most are synthetic...
TheMaDMAli 2 months ago
@TheMaDMAli
yes but those are derived from compounds extracted from the poppy. like oxycodone being an analogue to thebaine, etc.
JokersAce0 2 months ago
@JokersAce0
Untrue, most all opioids are completely synthetic, ie. fentanyl, methadone, tilidine, and their derivatives etc. I'm a pharmaceutical chemist lol
TheMaDMAli 2 months ago
from codein to krocodill
beruman 3 months ago
Heroin is a brand name that is owned by the Bayer company.
ACCSESS247 3 months ago
I`ve heard that there is only a molicule of difference between plastic, and cheeze wizz in a bottle, is this true?
dhebert111 3 months ago
isnt a small percentage of the codeïne you ingest metabolized to morphine.
ajuinkonijn 3 months ago
@ajuinkonijn yes it is. But strangely, if you take more than 400mg of it, this process stops.
djteac 1 month ago
@ajuinkonijn Yes.
Bobamuntung 1 month ago
Just a small correction: the name Heroin is not "street slang," but it was a brand name given to that drug by bayer, who tried to sell it as a cough medicine of all things...
whispersandechoes 3 months ago
@periodicvideos Brilliant video. I'd like to see a video about Tramadol, as I moved from being on morphine while in hospital to spending a couple of weeks on Tramadol at home (they don't send you home with morphine!) The profuse sweating and withdrawal symptoms were pretty awful.
Word to the wise, kids - Don't take prescription medication unless it's absolutely necessary. Even if you're in hospital it can pay to say, "no thank you". Cannabis and opiates are VERY different things.
nagualdesign 3 months ago
Can you do a video on DDT please. I have heard that it is not nearly as toxic as earlier literature would suggest. It remains one of a very few chemicals in the fight against malaria.
oomblikkies 4 months ago in playlist More videos from periodicvideos 26
@oomblikkies you actually wrong, ddt is extremely dangerous chemical as it accumulates and last very long witihin ecosystem, poisoning many different animals and inhibiting reproduction. ddt is not nearly as safe as some interest groups want you to believe. in the fight against malaria there are better and more effective ways, take the lesson from borneo
8ball154 2 months ago
Please make a video on THC (in cannabis) PLEAE :)
uxa1 5 months ago 65
@uxa1 Actual i think a video on DMT wold be more interesting
Si3z3 1 week ago
cool go make sum thanks
MrFarout88 5 months ago
HI! Thanks for posting videos like these. They're especially useful to pharmacy students just like me! =D Your videos have given me a greater appreciation for chemistry. THANKS! =D
DrRigolettoPianist 5 months ago
hey realy cool videos! i like them a lot! where can i buy these cool molecule models? i think they would help me learning...
terlandkennedy 6 months ago
what about fentanyl? isn't that supposed to be about 100 times more powerful than morphine?
zimondlord1 6 months ago
From the poppy seed pod, mostly. The opiates are also in the seeds, but they are harvested by cutting the seed pod and collecting the sap which exudes.
BuickDoc 6 months ago
Keep up the stimulant videos, *cough cough* caffeine.
danx033 6 months ago
Thanks for the great video :) It would be great if you could make a video explaining the processes through which opiate users gain a tolerance and physical addiction.
fikealox 6 months ago
Can you do a video on HOW these molecules are actually made? How does science isolate them, do they stack them on a molecule shelf? How do they "bond" the bits together, what's the glue of molecular biology and how do scientists do it?
johnmacward 6 months ago
I'm autistic and opiates do an amazing job at quelling the constant, throbbing psychological pain I feel on a daily basis due to my illness. Psychological and physical pain are mediated by the same neural circuitry, so I'm just as justified as a cancer patient in my self-medication.
SSJkiller 6 months ago
I wouldn't say that someone is lucky to have needed it. I will say, though, that those who do are lucky enough to have it available.
rogerdotlee 7 months ago
You guys should do cannabis.
Jedi3231 8 months ago
Aussie accent....so farmer
KatiushaVN4 8 months ago
@KatiushaVN4 He's definitely not Australian. He's English.
ravenscroftpaterson 8 months ago
Ketamine is used in emergency medicine where morphine is not enough. Any chance of a video on that? Would be quite interesting as it is also used as a horse tranquiliser and recreationally by "the kids". Those crazy kids...
saggybean 9 months ago
can we get a tryptamine video?
imantisocial 9 months ago
please create a video about how to create new chemical connections like "improving morphine". Do people start with a virtual computer design and then put atom next to atom using an electrone microscope - i doubt that.
zurechtweiser 9 months ago
"And that is called Heroine! Which I'm sure.. uhg, sure you'll have heard of."
calumisdead 10 months ago
3 people have been to rehab hahaha
2sxc4xtc 10 months ago
After surgery I was hooked into a huge cylinder of morphine and it had absolutely no effect on me. Pethadine, however, is quite nice.
DrBones666 1 year ago
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gordongate 1 year ago
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krstcmjns 1 year ago
The interviewed man said that morphine is the strongest analgesic, with nothing approaching it in potency.
Fentanyl is 100 _times_ more potent than morphine, and some of illicit drugs based on it are even more powerful.
For non-opiod drugs, Ketorolac approaches the strength of morphine.
AlexBesogonov 1 year ago
@AlexBesogonov In all fairness he later goes on to mention that dia-morphine is stronger aswell, i think it was more of a spur of the moment excitement thing. However yes there are plenty of analgesics which are more active than morphine.
geeupson 1 year ago
@AlexBesogonov That reflects only the dosage you need to use, not the real effectiveness of relieving the pain. As far as I know, morphine indeed is the best.
Baalsaack 1 year ago
After seeing the video on aspirin I can't help but notice that aspirin's activity is partly based on an acetate group as well. might this have anything to do with why heroin is more active?
japanesepoptart 1 year ago
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halarmhalarm 1 year ago
Comment removed
halarmhalarm 1 year ago
@japanesepoptart
no, it just improves farmacodinamic charatheristics of morphine alowing it to much easily pass blood-brain barrier
halarmhalarm 1 year ago
@halarmhalarm
Oh, so it just improves the rate and amount that can get in? ohhhhhh... So they have the same effect if equal amounts are in the brain?
japanesepoptart 11 months ago
@japanesepoptart yes, but heroin i still considered stronger becouse of this charatheristics, it does not only pass through blood-brain barrier easily it also passes through all those structers inside the brain makeing it much more easily to distribute through-out the brain
halarmhalarm 11 months ago
synthetic chemists and unlicensed drug dealers. You forgot 1 part. :P
pikachuthesquirtle 1 year ago
Hello, I just wanted to say I'm a huge fan of your videos.. As a medical student, I was thinking: maybe you could do a medical channel, like sixtysymbols for physics? It would be great and interesting for people to learn about their own bodies and at the same time it could counteract antivaccination movements and alternative medicines that form due to a lack of general understanding of modern medicine. Medicine is also a good example of application of many branches of science!
Nydracommander 1 year ago
The raw material for natural ore semisynthetic opiates are mainly from lagal poopy fields in India. The instability in the Afghaninstan region doesn't really affect the medicinal supply of raw opium.
jesustheinvincible 1 year ago
Show us how to add those acetyl groups to the morphine molecule.
Acetic Anhydride?
E2qNX8btraQ3zRD6J7fc 1 year ago
I love chemistry!!!
GabrielAnsley 1 year ago
This comment has received too many negative votes show
The interviewer asked, "Have you ever been unlucky enough to meet Morphine?" His choice of words is a bit ignorant. Ask anyone who's been in severe pain; they wouldn't consider themselves unlucky for a drug to be available to help them. Just ask any woman in labor. Society has given the opiates a bad rap.
ajcusn 1 year ago
@ajcusn you don't need me to tell you how pedantic you're being...
If I'd said "Have you ever been LUCKY enough to have morphine?" someone else would have written that you're hardly lucky to be in such pain in the first place... Overall surely the luckier person is he or she who is not suffering at all.
Anti-cancer drugs are great, but I still feel it would be appropriate to say someone with cancer has suffered a misfortune.
And I don't think this video gives morphine a bad rap! :)
periodicvideos 1 year ago 145
@periodicvideos No, having morphine is lucky. Having pain resulting in you needing morphine, that sucks. But getting morphine in and of itself, particularly getting it either whilst you're in no pain, or whilst you're withdrawing from it, is like being wrapped in God's warmest blanket...so yes it is a lucky thing indeed
The3rdPlateau 8 months ago
@The3rdPlateau
Yes, being able to have morphine in a bad situation is good.
But, I've yet to meet the person who would rather be in extreme pain and then take morphine, than not be in pain to begin with. As they said too, morphine has some nasty side effects: I've never taken it myself, but I heard that it makes your head feel like a huge lead brick.
japanesepoptart 7 months ago
@japanesepoptart That's not what I meant. Being in a normal situation and having morphine is awesome, because (in my first-hand experience) it feels like pure concentrated bliss moving through your bloodstream...being in a bad situation sucks no matter what, whether you have morphine or not. I only meant that having morphine is great, because being on it feels awesome. Being in pain is not necessarily a prerequisite to being on morphine. Although if you're getting it because you're in pain..
The3rdPlateau 7 months ago
@The3rdPlateau
I suppose. But I think they were implying being in pain. Anyway, if you really get technical about it, having morphine exist in this world is probably a good thing. The opioid family is very vast and contains many different chemicals like morphine, codeine, heroin, hydrocodone, and oxycodone. All of which have many different uses ranging from minor pain, to the most severe pain in your life. Actually, my neighbor is taking Vicodin right now to help him with his broken ribs.
japanesepoptart 7 months ago
@japanesepoptart ...then yeah, that sucks. That's just not what I meant.
The3rdPlateau 7 months ago
@japanesepoptart that,makes you constipated as hell,slows your digestion, habitual use will make you fat,will make you sweat profusely,can give you massive massive gut wrenching headaches if you have a intolerance to it (first hand experience on all counts).and its also a bitch to get off of!
KeithWasHere1 6 months ago
@KeithWasHere1
Really? huh. well, they didn't want to give my neighbor a brace because he's old and has a higher chance of getting pneumonia. so they just gave him vicodin and said to not engage in a lot of physical activity for a year.
japanesepoptart 6 months ago
@japanesepoptart lucky him...Vicodin is some good stuff
KeithWasHere1 6 months ago
@periodicvideos
Your right! Morphine (and all the other illicit drugs for that matter) get a bad rap!
The medicine I take for ADD every day comes for the same family as methamphetamine!
The way I see it, drugs don't break the law or ruin your life; you break the law and ruin your life with drugs.
japanesepoptart 7 months ago
@periodicvideos Had Morphine, was wired up to a huge wonkin' tube of it once after major surgery. Absolutely no effect what so ever. Pethadine however, that was nice but not as nice as you'd think.
DrBones666 4 months ago
@DrBones666 I spent a week on morphine after an operation and I agree that it's difficult to tell if it's having any effect, going straight from the operating theatre to being on morphine. The psychological effects are also quite subtle. However, due to a faulty machine I was without morphine for a night, and very early the next morning I awoke in absolute agony. I cannot express the pain that I felt. So morphine was actually having a very strong effect - enough to make me feel nothing at all.
nagualdesign 3 months ago
@nagualdesign I hear what you are saying. In my case though, I pushed the delivery button as much as I could, then the next day didn't push it at all. No difference. Then I told them to disconnect me. They came in, tested it to make sure it was actually delivering the substance into my IV. It was. Disconnected me. Next day, no difference. There was pain, I'd been in surgery for 13 hours and had all my intestines re-routed and re-hung but there was just no difference. Who knows.
DrBones666 3 months ago
@DrBones666 The big syringe contains very dilute morphine. One press of the button delivers a 1mg dose. If you press the button every 5 minutes (the maximum the machine allows), as I ended up doing too, you quickly build up a tolerance. As the pain was getting worse I complained that the machine wasn't working and they upped the dose to 1.5mg, which worked fine. People have very different perceptions of pain, and sometimes the most gruesome operations are the quickest to recover from.
nagualdesign 3 months ago
@periodicvideos Don't need to be in pain to get morphine, just need to be lucky enough!
KeepThemInPoverty 3 months ago
@ajcusn he said 'unlucky enough to NEED morphine' not 'meet morphine'. Changes context entirely
boswell255 1 year ago
@ajcusn He said, 'unlucky enough to "need" Morphine' anyhows. pull ur head outa ur butt...
xferociousx 9 months ago
@ajcusn hmm seems a bit strange that this comment is hidden. Seems to make a legitimate point. As is the reply point by periodicvideos.
TrevM 7 months ago
@ajcusn
harpdarp.jpg
1997xander 6 months ago
@ajcusn Or it could be construed in another way, as in "Have you ever been unlucky enough to be in a situation which calls for morphine?".
georgie4790 6 months ago
@ajcusn Very true. It's called politics, money & ignorance.
Legalise all drugs : then treat it as a social & health problem, not as a legal issue.
homham1 3 months ago in playlist DRUGS
How are painkillers different from neurotoxins?
webpotato 1 year ago
@webpotato
"How are painkillers different from neurotoxins?"
the two words are general terms. in otherwords, a painkiller KILLS PAIN. and a neurotoxin is TOXIC to NEURO processes. example. if u injest opium then it can be a pain killer but if u injest enough opium then it can be toxic to neuro signals like the ones that make you breath or like ur heartbeat. as a sidenote, some painkillers cannot be neurotoxic although they might kill u other ways; and some neutotoxics are not painkillers.
CakesPix 1 year ago
@CakesPix
A wise man once said, "Every molecule can be safe or toxic: the toxicity depends on the DOSE not the compound."
japanesepoptart 1 year ago
Heroin works best for me.
Edawg649 1 year ago
Where do you get the stuff to make those molecule models? I want some.....
pbtwentythree 1 year ago
This has been flagged as spam show
@pbtwentythree
"Where do you get the stuff to make those molecule models? I want some"
search "wikipedia molecular model". at bottom of page there is one section showing computer software so u can make models on your computer. and another section has lists where u can buy model kits.
CakesPix 1 year ago
This has been flagged as spam show
@pbtwentythree
"Where do you get the stuff to make those molecule models? I want some"
search "wikipedia molecular model". at bottom of their page there is one section showing computer software so u can make models on your computer. and another section has lists where u can buy model kits.
CakesPix 1 year ago
He's getting a buzz off that model.
monkeyboy4746 1 year ago
Really cool video! Love it.
Furiouslyfappin 1 year ago
also at periodicvideos, the Seeds of the poppy is not where they commercially extract the alkaloids; harvesting equipment gathers the entire plant. although, re seeds, some species' seeds do contain some alkaloids (contrary to what u will read on some gov websites).
CakesPix 1 year ago
@ periodicvideos
at 1:00 it says 'for some reason the poppies in afghanistan and pakistan grow stronger'...the reason for variance in poppy strength is because there is many Types Of opium poppy. the somniferum species has many sub-species and then within those sub-species there is other sub-groups. total alkaloid content can vary from 1% to 17%.
CakesPix 1 year ago
omfg whoever thumbed down, has no life!! they saw matismatts comment and thought "leeme be a fat dick and thumb down"
sk8el3mentfreak 1 year ago
Very interesting. But what is opium? It's in the same family.
Kurtlane 1 year ago
You should do one on THC.
SaintofKillers66 1 year ago
Fentanyl lollipops for cancer patients are the best...
cuntylishus 1 year ago
So if i swallow that plastic tree....i'll feel fine?
dojufitz 1 year ago
I think laughing gas i.e. N2O is actually much more effective than morphine. How about a video about that?
ASKaPHYSICIST 1 year ago
Please do a video on DMT and the pineal gland. Thumbs up if you agree.
Brudof 1 year ago 36
@Brudof There is no scientific proof that DMT is generated in the pineal gland, it's really a theory from one scientist (Rick Strassman) that was never proven, and was, for some reason, happily adopted by new age, parapsychology and psychedelics enthusiasts. It's a myth, and doing a bit of research through journals and papers will prove it.
metabog 1 year ago
@metabog Great, but it doesn't change the fact that it would make for a very interesting video.
Brudof 1 year ago
@metabog And yeah I've read Strassman's book ;)
Brudof 1 year ago
Can you do a video on substituted phenylethylamines.
That would be very very interesting
mewrox99 1 year ago
@mewrox99
Like there's not enough information about that out there already.
His reasearch is about blocking pain. NOT geting high.
JesusHChrist2000 1 year ago
3-Methylmorphine is Codeine whereas 6-Methylmorphine is "Oripavine", one of the alkaloids of the Oriental Poppy (P. orientalis and P. bracteatum). It is interesting how 3,6-Diacetylmorphine is a slightly more potent analgesic than morphine whereas 3,6-Dimethylmorphine would produce side effects similar to Strychnine. That one would be "Thebaine", an alkaloid from which oxycodone, oxymorphone, and etorphine are derived from.The last one being appx. 1,000-3,000 stronger than morphine. Interesting
Nguli34689 1 year ago
@Nguli34689 hey, cool post but note:
--6-methylmorphine is not oripavine. There's an extra degree of unsaturation on oripavine, so the 14 carbon is not quaternary. This is not trivial cuz it changes the shape and flexibility of the molecule, and I suspect oripavine's toxicity is due to the extra rigidity at the 14 carbon.
--For the same reason, 3,6-dimethylmorphine is not thebaine.
--Incidentally, "6-methylmorphine" is known as heterocodeine, and is 6 times stronger than morphine!
opiumgland 1 year ago
@opiumgland Thank you for correcting me on this. I was using the 9th and 10th edition of the Merck Index and a few JACA as the source, but those were from the mid-1950's and I did not have anything which suggested to me about the shape and flexibility of oripavine's molecule. This is interesting and I don't mind the catching up I have to do. I looked again at the molecules and yes, I didn't see the difference before at the C-14 position, but now I do. Thank you for correcting me. :)
Nguli34689 1 year ago
"horrific" withdrawls, more like a very bad flu.
gordonbrownsfeet 1 year ago
Woah, interesting how close all these molecules are to eachother. Now, I have a question, I can not take codeine because I will get knocked out and have a short period of amnesia after that, does that mean I can not take morphine either? I would then have to notify medical personal when I need to be taken to the hospital, when ever needed.
crusiatusblack 1 year ago
@crusiatusblack Only your MD or Pharmacist can really answer that--
The molecules are very similar but their pharmacology may be very different.
It could go either way so consult with your physician if you really need to know.
ALAPINO 1 year ago
@ALAPINO I will, to be sure, thanks :) Still, so interesting how little these molecules are different.
crusiatusblack 1 year ago
when he said it looked like a t-shape..it looked really awkward..
kinda look like a penis if im being honest
XD
scorpserpent 1 year ago
what's the chemical formula for heroin plz tell me; im doing a project where we research a drug........and i got heroin and i need facts
ArmoredWerewolf 1 year ago
im allergic to morphine... when i was 5 years old i was in the hospital for 2 broken wrists. they give me morphine to stop the pain and i turned purple and got hives all over and passed out.
ChemHow2 1 year ago
Wonder if you could go from Co-codamol to morphine..
you would need to go from ether -> phenol.. with some reducing agent like nabh4
Bimm3rcc 1 year ago
@Bimm3rcc sodium borohydride doesn't cleave ethers I don't think; normally ethers are cleaved by refluxing in concentrated HBr, but this will not convert codeine to morphine because both codeine's ethers would be cleaved.
The laboratory reagent often used to convert codeine to morphine is pyridine HCl. Rhodium has a "home bake" procedure for this but I'm told it's low yield.
opiumgland 1 year ago
Brilliant video! I love how he shows what atoms connect to change the compound!
madjimms 1 year ago
wow! 0 thumbs down. Everybody likes morphine and heroin!
Matismatt 1 year ago 55
@Matismatt Every Junkie is watching this video too. Learning how to make your own addiction eh?
Jadandlud 1 year ago
@Jadandlud Simply making an observation.
Matismatt 1 year ago
@Matismatt too late, some jackass or someone without a brain thumb it down.
rifleman1002 1 year ago
@rifleman1002 it´s the beauty of the free expression world as is in this quote attributed to Voltaire "I disapprove of what you say, but I will defend to the death your right to say it." peace Lo
halamano 1 year ago
@Matismatt You always get hater... now there are 4!
hedleypanama 9 months ago
@hedleypanama They are not haters, man.. They misclicked while high!
Matismatt 9 months ago
@Matismatt 5 people have just tried it
Submania100 8 months ago
The most acute pain I had, turned out to be a blocked and infected sinus! Diagnosed as a root canal problem and after an hour of drilling and packing and filling at a dentists! I was crying with pain! Antibiotics sorted the pain after 2 two days. Meanwhile I took codeine pills.
nige213 1 year ago
Is a synthetic chemist as good as a real chemist?
anonysquirrel 1 year ago 3
Texas-shaped clock on the shelf above his head. :o]
ElveeKaye 1 year ago
PLEASE make more videos on the chemistry of psychoactive molecules!!
PartVIII 1 year ago
this guy reminds me of the professor, =]
fufulog777 1 year ago
The world's biggest producer of pharmaceutical (ie: LEGAL) opiates, is Tasmania - a large Australian island.
They have poppy farms there.
Also the Trainspotting withdrawal scene was totally unrealistic, they took too many artistic liberties.
IN REALITY Heroin withdrawal is only moderately worse that Nicotine withdrawal.
ALCOHOL withdrawal is worse than both, and can actually kill you.
Source for withdrawal info: Dr. Jack E. Henningfield
(google his name to see useful a drug comparison chart)
roidroid 1 year ago
This has been flagged as spam show
@roidroid "IN REALITY Heroin withdrawal is only moderately worse that Nicotine withdrawal." LOL sure, buddy
WarEqualsPeace 1 year ago
The worst pain I've ever had was a knee in the groin when in school. I got no sympathy from the female teacher that came along, in fact she was pretty rude about it. "Get up off the ground" she said, "you're blocking the queue." "FUCK OFF!" First and only time I ever swore at a teacher but as soon as I did I think she understood because I didn't get in trouble for it.
Pazma1 1 year ago
I vote for this guy to do all the videos from now on.......but maybe I'm a little biased..
I'm a synthetic chemist.....
buzzausa 1 year ago
Hmm that comment at the end... maybe I should go see a dentist.
noblessus 1 year ago
Codeine made me nauseous for days after one dose and it didn't even help the pain of having a tooth removed. Anyone know why it didn't work on me?
Craydon 1 year ago
@Craydon smoke marijuana or injest it to counter the stomach issues
eLLriDe420 1 year ago
@eLLriDe420 Umm, no I will never smoke or ingest that, I have two more teeth coming out and I would rather take the pain than become a junkie.
Craydon 1 year ago
@Craydon lol you dont become a junkie. stop listening to what your 3rd grade teacher told you in health class, pot is harmless, i let my kids some it.
eLLriDe420 1 year ago
@eLLriDe420 If you're giving your kids pot then that's all the evidence I need to say it does major harm, that or you're just a idiot stoned or sober.
Craydon 1 year ago
@Craydon What harm?
madjimms 1 year ago
@Craydon Codeine is an awful choice of painkiller. The codeine itself has little effect on pain, but can cause nausea etc. To kill pain, it must be converted into morphine by enzymes in your liver. 7% of ppl lack the necessary liver enzyme (CYP2D6) for this conversion. They will feel little or no pain relief, but still get the unpleasant side effects. IF this is your problem, switching to a different opiate should work - maybe vicodin?
p.s. cocaine in solution is the BEST fix for toothache!
WarEqualsPeace 1 year ago
@WarEqualsPeace Interesting info followed up by something I'm never going to do.
Craydon 1 year ago
@Craydon You won't get high from cocaine in solution: it'll act as a local anesthetic.
opiumgland 1 year ago
@opiumgland
it IS quite possible to get high from cocaine in solution, it is how cocaine is able to pass through mucus membranes in the nose; so to use as a local anesthetic u would want to control the Amount Of the cocaine in the solution..also the Type of Solution u use will matter
CakesPix 1 year ago
@WarEqualsPeace That view is being challenged: that CYP2D6 is essential to the activation of codeine. There is evidence that the major active metabolite of codeine is not morphine but C6G (the 6-glucuronide ether of codeine).
Of course, inducing CYP2D6 certainly doesn't hurt codeine's efficacy ;)
opiumgland 1 year ago
@opiumgland Thanks for the info update! I haven't studied this stuff in earnest for close to ten years so I've missed a lot. I'll definitely look into this.
WarEqualsPeace 1 year ago
@opiumgland Tagamet and Tussin, my friend. Tagamet and Tussin.
WarEqualsPeace 1 year ago
@Craydon
it is a common side-effect to experience nausea with some opiate products, especially when someone is using for the first time. one possible way to get around it is to use very little the first time or two so later the body will be used to it.
CakesPix 1 year ago
@CakesPix It doesn't really matter, ok yes it sucked to be that sick, but codeine didn't relieve any pain at all for me so there's no point in ever taking any again.
Craydon 1 year ago
@Craydon
"it doesn't really matter, ok yes it sucked to be that sick, but codeine didn't relieve any pain at all for me so there's no point in ever taking any again."
just fyi, codeine is the mildest version of opium so maybe its best if it isnt used as ultimate test. also, some conditions require a muscle relaxant to accompany the pain killer (example ULTRAM).
re the initial nausea u spoke of, be aware it can (also) occur if u take just 1 or 2 pills too many
CakesPix 1 year ago
@Craydon
ps-to elaborate on the nausea issue. nausea can occur if your liver is already maxed-out by other drugs/substances. example, if u take treatment of other type(s) but Then took codeine; the extra load on the liver can make u ill, like a hangover can occur with alcohol. usually doctors perform periodic liver blood test because byproducts can build up and become fatal. fyi, not all drugs accumulate in the liver, some accumulate other places.
CakesPix 1 year ago
@CakesPix I am a pretty regular over-the-counter pain reliever user (mostly Ibuprofen). But because of that (and other reasons) I don't drink.
Craydon 1 year ago
The name Heroin was made by Bayer when it was marketed toward women and children against sore throat. Would supposedly make you feel like a Heroin (female hero.)
jimdidr 1 year ago 23
Its said that people with teeth pain think everyone else is happy
ricardjorg 1 year ago
The worst pain probably I have ever got is from shingles I got once on my arm. It hurt.
G3org3Master 1 year ago
smoke weed... it works better than this shit.
TheNemestrinus 1 year ago 3
inb4 "do weed"
KzrrainzYes 1 year ago
Now there needs to be a video on how to make heroin from the opium. Haha.
Thanks for the upload.
Intervene 1 year ago
Fascinating. We always wonder "Why does this work?" Well, some of us do. I want to know how things work, love your videos.
phnixlady 1 year ago