I think this is a pretty good brief overview of Alzheimer's drugs but I feel compelled to point out a couple of things:
1: Bapineuzumab did not show improvement but it did show effects in people with a genetic disposition to Alzheimer's disease that is quite common (APoE-4) and is undergoing further testing to see if it may be effective in these people
2: While drugs addressing amyloid are the most common pathway being examined there are other approaches, some of which are also looking good
FORBES: British neuroscientist John Hardy says there are two key questions to ask about the failed Eli Lilly study:
1) Did the drug hit the target but still not work? If this is the case it is worrying for the whole class of drugs.
2) Did they have imaging data showing amyloid cleared?
If the amyloid is cleared in the patients who are getting the drug and the disease is getting worse, it would be a bad sign for future drugs still in testing.
@xmenrus haha - actually it got much better between 1965 and 1970 - after I hired a gorgious brunette (of course our relationship was purely professional) lol
@bvongrabe Very good! Back in the USA my secretary was an irish girl with 'fire engine red hair (everywhere I looked.) Also a professional relationship. I am drinking ozonated sterilized water, 4 oz a day. It oxygenates the body and destroys viruses because H2O2 is positive and it attacks cells like cancer, aids, etc. to get the extra electron to rebalance its charge. Aids, cancer, etc. cells explode. Beautifull. I found an ozonator on Ebay for $30.00. Drink on an empty
@xmenrus Drink on empty stomach and oxygenated water flows into the blood stream quikly. I call it natures vacuum cleaner. Thoroughly cleans the blood of all known pathogens. See Dr. Robert Beck, youtube.
@StandUp555 My HDL had sunk to catastrophic levels even though I had used Gemfibrozil for 3 years. I tried first ADT2 and after 4 weeks experienced a clarity of my thinking that was downright scary! Unfortunately, unlike ADT3 the effect fizzled away because I had acquired tolerance for one of the components. We overcame that in ADT3 - though it took me almost ten years to find the solution.
@StandUp555 Good you mention your intellectual work. It has been clearly established that the brain adds new cells (derived from stem cells) even into high age provided it is exposed to intellectualy challenging stimuli
I think this is a pretty good brief overview of Alzheimer's drugs but I feel compelled to point out a couple of things:
1: Bapineuzumab did not show improvement but it did show effects in people with a genetic disposition to Alzheimer's disease that is quite common (APoE-4) and is undergoing further testing to see if it may be effective in these people
2: While drugs addressing amyloid are the most common pathway being examined there are other approaches, some of which are also looking good
hashcook 8 months ago
Been missing you, JB. Thanks for posting this.
imjustagirl776 1 year ago
FORBES: British neuroscientist John Hardy says there are two key questions to ask about the failed Eli Lilly study:
1) Did the drug hit the target but still not work? If this is the case it is worrying for the whole class of drugs.
2) Did they have imaging data showing amyloid cleared?
If the amyloid is cleared in the patients who are getting the drug and the disease is getting worse, it would be a bad sign for future drugs still in testing.
bvongrabe 1 year ago
YouTube's newest strategy: Replace Tags with the name of the author. Don't they get it that tags increase distribution?
TAGS: ALZHEIMER'S DISEASE, DEMENTIA, HYPERLIPIDEMIA, CHOLESTEROL "JOHN HARDY", X-PHARMA, ADT3, PFIZER, DIMEBON, AMYLOIDS, WyETH, ELAN, NEUROCHEM, "ELI LILLY", "MARK SMITH", "BERISLAV SLOKOVIC", PLAQUE
bvongrabe 1 year ago
This has been flagged as spam show
LYME BORRELIOSIS AKA LYME DISEASE, IT IS A CLINICAL DIAGNOSIS BECAUSE THE ACCURACY OF TESTING FOR LYME STINKS
please it is worth looking into
see the link below
w ww.youtube.com/watch?v=3nIuIF6q8FA
lsglookout 1 year ago
Very Informative.....and eye opening... Thanks
SEFX3D 1 year ago
I was in Heidelburg in 1961-1963: Patrick Henry Village, European HQ, US Army. Lovley city: Cold beer and hot women. Couldn't get any better.
xmenrus 1 year ago
@xmenrus haha - actually it got much better between 1965 and 1970 - after I hired a gorgious brunette (of course our relationship was purely professional) lol
bvongrabe 1 year ago
@bvongrabe Very good! Back in the USA my secretary was an irish girl with 'fire engine red hair (everywhere I looked.) Also a professional relationship. I am drinking ozonated sterilized water, 4 oz a day. It oxygenates the body and destroys viruses because H2O2 is positive and it attacks cells like cancer, aids, etc. to get the extra electron to rebalance its charge. Aids, cancer, etc. cells explode. Beautifull. I found an ozonator on Ebay for $30.00. Drink on an empty
xmenrus 1 year ago
@xmenrus Drink on empty stomach and oxygenated water flows into the blood stream quikly. I call it natures vacuum cleaner. Thoroughly cleans the blood of all known pathogens. See Dr. Robert Beck, youtube.
xmenrus 1 year ago
Thx .. was interesting , and I concur .
Am currently taking chloresterol-sinker tablets since 4 yrs. now.
StandUp555 1 year ago
@StandUp555 My HDL had sunk to catastrophic levels even though I had used Gemfibrozil for 3 years. I tried first ADT2 and after 4 weeks experienced a clarity of my thinking that was downright scary! Unfortunately, unlike ADT3 the effect fizzled away because I had acquired tolerance for one of the components. We overcame that in ADT3 - though it took me almost ten years to find the solution.
bvongrabe 1 year ago
@bvongrabe .. thanks , again interesting.
I think I'll get another check-up, to see what levels I now have.
I went from 300 down to 150 a few years ago, and assumed it would remain that low. Thanks for the insight ( building tolerance against the pills ).
Am currently using "Simvastatin" 10mg. per day FWIW.
Also, I agree with you on "use it or lose it".
Am still developing complex (software) systems, i.e. still using my brains.
Have to keep some ca. 4000 variables in my head .
StandUp555 1 year ago
@StandUp555 Good you mention your intellectual work. It has been clearly established that the brain adds new cells (derived from stem cells) even into high age provided it is exposed to intellectualy challenging stimuli
bvongrabe 1 year ago
Excellent: thanks, Bernt.
AJsOwner 1 year ago