The Action Potential

[artistic0director]

Ths is great!!

[305manuelito]

That was the best explanation ever

[illyxxolicnaxim]

That made my day. Very clear, reassuring, and witty.

[highstride99]

Brilliant and very well made presentation, simple, to the point and well explained. If only my teacher was as good as you ;)

[JapaneseGypsy]

hey thanks a lot, even though your accent made it sort of difficult.. it made me listen more at least. omg u dont how thankful i am for making this simple!

[veritasuser]

You are awesome, thank you.

[UkiSmileyFace]

Wow, thanks so much! I have my biology exam tomorrow and I couldn't get my head wrapped around this concept of action potential, and you REALLY helped me out! Thanks again!

[hssailingteam]

Great video, just one thing: There are two tipes of refractory period, the absolute period and the relative period. During the absolute period, which comprises from the start of depolarization to the beggining of the last third of the entire process (right before hiperpolarization occurs on the grapf), absolutely NO stimulus can start another potentia. But during the relative refractory period itis possible to start another depolarizacion process, only that the stimulus has to be very potent .

[hssailingteam]

@hssailingteam sorry for the grammar, damn typos.

Reference: Phisiology 6th ed., Berne and Levy

[nicolehamilton12345]

thank you so much!

[Mjhond]

I am very happy to see the vidoe after you give this The movement of ions to correct hyperpolarisation occurs by active transport using the sodium-potassium

[DrSciProf]

@Mjhond Hyperpolarization is NOT corrected by the Na/K pump. The Na/K pump restores the concentration gradients, but the Na/K pump only contributes 1-3% of the resting membrane potential. The hyperpolarization is corrected by leak channels, which come into play after an action potential but before the Na/K pump kicks in. You can read about this and the derivation for the contribution of the the Na/K pump to RMP in Sherwood's physiology text.

[Ondelendo]

I Love The Video It Can Increase My Knowledge The movement of ions to correct hyperpolarisation occurs by active transport using the sodium-potassium pumps 

[anakmudajaman]

Steady I Really Like This Video The movement of ions to correct hyperpolarisation occurs by active transport using the sodium-potassium pumps

[bebeheuy]

Good, I like that you share this video, I wish success always rather than by diffusion as the narration states. Thanks to user SirBlibofDoh for pointing this out.

[imegatrone]

Nice Video That You Share , So Very Nice Thanks You Note there is a small error at around 2:20. The movement of ions to correct hyperpolarisation occurs by active transport using the sodium-potassium

[willamricard]

I Really Like The Video From Your The Action Potential

[bundawartini]

Your Video Is Very Useful Sharing The Action Potential

[FocusWLN]

The clarity of animation is really good, and the information. Just a quick question, I've always understood the refractory period to be from the action potential being emitted to the resting potential being restored, not just hyper-polarisation. Can any one confirm which it is? cheers

[flyers4life123]

i dont understand how the depolarization propoagtaes. The stimulates causes the sodium channels to open, but what causes the neighbouring channels to open?

[hupper12345]

hey thanks. I like the graphics....very creative.



[Caiaiman]

Thanks for the video, it is very clear and easy to understand. But I have a question and I am wondering whether you will be able to help me. In my WJEC book I have a diagram of a action potential graph, and it shows that the direction in which the impulse is transmitted goes from refractory period first. I do not understand this part and why the impulse travells this way/direction. Could you please try and help me? Thanks

[biopodcast]

@Caiaiman 2 things to consider: Remember that the action potential graph shows the electrical potential at a single point in the axon and does not say anything about the direction of the impulse. It so happens that I have animated the impulse travelling from left to right but I could have done it the other way around and the action potential trace would look the same. Secondly, the refractory period has the function of preventing the impulse from being propagated in both directions. That help?

[Mafrundee]

wow this was really good video ! Thank you !!

Keep on going ^^!!

[DrDoniak]

Perfection :)!!! Good job

[9klam9]

Thank you so much. I understood this from the 1st time.

[ThE420DbOY]

make the sound louder you fuck



[starsoftrackandfield]

@ThE420DbOY learn some manners.

[ThE420DbOY]

@starsoftrackandfield

suck ma balls

[mmezzett]

This was so helpful! It put everything together in a simple and understandable way!



[vernonasian]

Thank you so much biopodcast, this is waaay better than the animations of other videos I have seen so far. I enjoyed the humor and how you carefully guided us through the diagram, thank you once again for your time and effort

[RozieeeKay]

Last minute study before my human biology exam!! i totally get this nowwwww! thanks champ

:)

[kris5gj]

Really liked it!!! Very helpful!!!

[DoubleSuited52]

Thanks for posting this! I was looking for a thorough and concise video of an action potential that I could show to my students. This is one of the best that I could find on the youtube. Cheers

[DoubleSuited52]

Thanks for posting this! I was looking for a thorough and concise video of an action potential that I show to my students. This is one of the best that I could find on the youtube. Cheers

[PhantomPasDeDeux]

I do believe you have just saved my BioPsych grade. Kudos! This was very easy to understand and the way you accumulated everything onto the action potential trace throughout the video kept me thinking and linking all the vocabulary together into the practice.

I think you also condensed a half hour of learning in-class into 4 minutes. Are you going to be teaching anywhere on the West Coast and can I attend your class? :)

[anatomyandneurobio]

no offense but u should either delete or recreate a corrected version of the video..errors are fucking detrimental

bio is confusing enough

i almost didn't see the correction comment :S

but other then that this vid is very well explained so kudos to that

[sacuna9999]

really useful. Thank you.

[McMurphyo]

Thank you!!!!!!! I was having the hardest time understanding how K+ reverted back into the ICF after hyperpolarization. Other videos seem to skip over the last part

[LordDohBoy]

dis nigga smart, but hella quiet

[MrRappinelvis]

really good stuff wish you made more vids

[megautubefan]

this was very helpful. thanks for posting.

[ayoopdog]

Good production quality lol

[like2shipspassing]

Thank god your british!

i was getting irritated at all the american and australian biology videos!

[BillieBaby143]

@like2shipspassing Why?

[MissShirshe]

Excellent video! Potassium ions are described, and Na/K as well, not like in the other videos where only Na channels are described. Fantastic!!!

[Alevelhelp]

@appelmak because the charge is still positive, its just saying that it is MORE negative relative to the outside/ inside. =]

[DaLoneFreeMarshmallo]

Love it :D Really helpful!

[maneatingtoilets]

I also dont get why they nerve impulse can just jump from on node of ravier to the next...



[kamikazeslammer]

@maneatingtoilets The membrane of the axon has sodium and potassium gates. Well if the axon is covered in myelin, no diffusion can take place until the impulse reaches a space where the gates are uncovered(nodes of ranvier). So diffusion only has to occur at a fraction of the places it would if the axon was unmyelinated.

[maneatingtoilets]

what do you mean by "polarized"? Is what you said before it, what it is?

[chsxtian]

@maneatingtoilets Polarized means it has an electrical charge, from the negative ions inside the cell.

[crackettt]

@chsxtian postitives ion. Both potassium (K+) and Sodium(Na+) are positively charged.

[Rabeej]

What a wonderful video! excellent and very clear explanations.

Please upload more videos like this.

Thanks alot for the upload

[GeneralX]

Wow man u could sell this on a dvd and i would buy it, better explanation then my teacher, cheers your a life saver!

[AppelMak]

If both K+ and Na+ have a possitive charge, then why is the inside of the axon at a negative charge?

[IAMHOTuKNOWit]

Love when you click the 1911 button. LOL

[petercourt]

Thanks for this - may I ask, how did you make it?

[biopodcast]

@petercourt

Hi Peter, I used Apple's Keynote to create the animation/presentation on a MacBook Pro and then to record the audio over it. As you can probably tell I struggled to get the audio levels right and some line-fumbling was left in because I had to do the whole thing in one take. There's probably better ways to do it but I didn't have the time to properly investigate all the options. Keynote is really very good for these animations though.

[CandyAdikt]

love your video! thank you! the play on words made it entertaining as well.

[SirBlibofDoh]

At 2:23, wouldn't a better description be: "... This is then corrected because the sodium and potassium undergo active transport through the sodium-potassium pump." What you say suggests that diffusion can take place from a lower concentration to a higher concentration, which isn't true. What you say sounds similar to Osmosis, but that's only true for water.

[biopodcast]

@SirBlibofDoh

You're right, that's an error. Thanks for pointing that out, I'll edit the description to warn people.

[eggmcmiles]

finally a good movie explaining the action potential! thanks so much!

[FreshVTHokie]

I hope you made this on a mac

[biopodcast]

@FreshVTHokie

I did.

[LowTone360]

This video was very beneficial. Great stuff :D

[lajeaune1]

very helpful, thanks so much. Gave huge insight, only criticism would be that the sodium and potassium pumps should be highlighted as well. However, very credible explanation of an incredible sequence of events!

[biopodcast]

@lajeaune1

I agree it helps to know how the NaK pump works but the A level syllabus which this is aimed at doesn't place much emphasis on it and so I left that out to avoid complicating the process unnecessarily. Thanks for your comment.

[Zatnikatel1]

Excellent video. I like how you correlated the action potential graph with the event inside the neuron. Just one suggestion though, in addition to understanding diffusion (passive transport) it is also helpful to understand active transport (the sodium potassium pumps).

[biopodcast]

@Zatnikatel1

Thanks for your comment. As a student I was always frustrated by the lack of explanation of how the graph related to the events in the cell and so I made this with the explicit aim of linking the two as clearly as I could. I personally find that the unique shape of the action potential trace is far more memorable than the ion movements inside and so I found it works as an anchor for each stage of the process.

[riv864]

excallent vid u r awesome

[MrWurstkopf]

plain, clear and simple - best video! thanks a lot

[makelikepooandrun]

very helpful thank you!

[031291fobbing]

very helpful, thaaaaaaanks!

[kplrocksteady]

amazing video! this is most deserving of an A++!