Action potential

[pullumpurna]

so complex! 

[dayyvuhhdg]

::mind blow::

[PickkSix]

needed that. test in 6 hours!

[lotr450]

Potassium ions do NOT diffuse out. The negative resting membrane potential inside the muscle fiber pulls potassium to the inside of the cell.

[theIllmaticClassic]

WOWW ..Wait.. whattt??!! Can you be a bit simpler. Its like this video is meant for you NOT to UNDERSTAND

[openurwingsevilangel]

thank God man made youtube!

[Edelweiz]

thanks for making this video, instead of staring at my notes for hours, this information just clicks into my head!

[frangoland]

please who can write as the voice says, word for word? thanks

[gilland9008]

This is so helpful! Covers everything I've been trying to figure out for the last 3 weeks of class. Simple, clear and wonderful animation! Thank you!!

[wooferpoofer]

"sealed holiness released into the class"

"A sealed cold rain has been split as a statement calling. I call in air strikes resulting in Iraq a nation and closure of the channel"

"causing the voltage gated Soviet generals in the vicinity to open the rioting calcium channel so the literal sense."

Movement of the problem I assume trip home in complex away from my ass around the mine fire drills.

Gotta love google trying to do the closed captions!

[RoniDream]

@hotjamz5

just like g.12 chem, huh?

well, the neurotransmitter stuff must be somewhat true, no?

[RoniDream]

@treasuredragon

AP? The difference in ionic charge? Don't you think that's slightly too transient to be considered a "thing", with all those pulling and repelling forces going on?

Don't get me wrong, I do believe in souls and would like to see how ppl prove it. Though, on the other hand, I don't feel that it's necessary and usually remain skeptical as a science student.

[Solja2010]

thanks man!

[owning541]

yup yup...^^ thanks lot...

[Megabombify]

sooo helpful

[justindavis2012]

so the ryanodine calcium channels are voltage gated? im trying to figure this all out and i thought i understood that they were opened by the binding of Calcium.... blah this stuff is so awesome yet kinda confusing.

[RoniDream]

@justindavis2012

you probably don't care by then, but I've got an exam on Monday [so I am practicing explaining this =P]

Before I go and confirm this, what I gathered so far is that di-hydropyridine sensitive calcium channels (DHP) in T-tubules opens [voltage-gated? looks like it from the video], perhaps the Ca++ it lets it changes the conformation of the tri-adic end "feet" which is what pulls the Ryanodine channel opens? [does that make it ligand-gated?]

[RoniDream]

@justindavis2012

also, see mattcarle21's comment

[jwu322]

Fantastic!! Very useful. Thank you!

[Shrubbs]

Uh-mazing!

[DharshanMani]

Sick video, i really liked it.

[Missnitamarie]

this really helped me understand the muscle contraction and all the components involved!!!

[vwb341]

good demonstration of the action potential!

[commogod25]

LMAO the closed captions are funny. If it actually said stuff like that I am sure it would be whole lot more interesting. LOL all in all a great visual aid

[kooziejr]

any reason why you didn't mention ATP causing contraction????????????? sigh! fundamentals!!

[DollProductions1]

Thanks for the video! The captions are so off though. lol

[sternblume]

Ok so, I'm sitting in the library with no headphones, so I turn on the "Closed Caption"... and I was like WTF?! The transcription is so fucked up it's hilarious, check it out!!

CC aside, the video is very well explained and detailed enough, and along with the other 2 vids... well, all my confusion's vanished away!!

Cheers mate!!

[mackat4ck]

wow thats complicated!

[KABJTube]

nice ...

[bouchra2alger]

should you put it in french plz???plz plz

[juxtacation]

Great vid!!!!!!!! Detailed from start to finish, could have had more on the actin-myosin interactions but everything else was top notch. Thanks for the visual aid!

[fryal89]

thx i helped a lot,,, i missed my lectures and it helped,,,,

[sriaeta]

anybody can do anything exams and marks are not measurements for his talent and worth.....agree with me.

[kooziejr]

@sriaeta notcompletely true..most people can do anything...but that doesn't mean a whole lot of people out there are not a lot better than them...

[waksibra]

@sriaeta cool. i'll jump off a building believing i can fly now.

[20BCeltics]

@waksibra notice the usage of the word "can" NOT "believe" can implies ability you are able to do anything you can do you believe what you can do but sometimes you can't do what you believe

psychological shit, bro

[alrubie86]

My exams next week. The pressure gettin to me means i aint takin this shit iN!

[jrzydevl951]

nice! im learning this stuff right now and this video made everything a lot clearer!

[TheSovietDollmaster]

Awesome, cool and helpfu! My exam is coming close. *fav'd*

[leb00rr]

wow i can't beleive that doctors and nurses are discussing my HIGHSCHOOL homework....i'm a seventeen year old lebanese student .....i feel soo proud and btw i love physiology!

[CatLoveKellyClarkson]

Are you all doctors....

I'm training to be a nurse and our curriculum has changed to almost the same difficulty as a doctor's course! I should've just done medicine rather than study so hard to get fuck all at the end!!

[craiglozier]

ahahaha.. nursing is no where equivalent to doctor.. you must be high

[mattcarle21]

DHP receptors release calcium in turn opening ryanodine (calcium stimulated calcium release channels) receptors in the sarcoplasmic reticulum thus freeing up more calcium.

[eejanaika123]

this brings back memories of physiology class at uni:D i loved action potential and muscle movement with troponin/actin/myosin. it`s the nostalgia u feel from a cartoon u watched as a kid....omg thanks heaps:D:D

[Samadhiatman500]

AWESOME!

[kcssexygemini]

thank you so much!!!! this video was very helpful to me!!!!

[nauticapnoy12]

Good luck on all your test!!

[nauticapnoy12]

1. AP moves down axon terminal

2. Exocytosis release synaptic vesicle containing Ach

3. Ach diffuse across the cleft and binds with Ach receptor

4. Ach dependent Na+ channel open up.

[nauticapnoy12]

5. Na+ goes inside cell that brings membrane potential to threshold or depolarize causing voltage Na+ channel to open up along sarcolemma.6. Ap travel from sarcolemma to T-tubule, which triggers the release of Ca+ from Sarcoplasmic Reticulum

7. Some Ca+ binds to the Tnc region of the troponin, which shift the troponin, thus removing the blockade in actin.

8. Myosin head combine with ADP+Pi binds to actin.

[nauticapnoy12]

9. Myosin head pull actin towards the center of sarcomere and ADP + Pi releases from Myosin head.

10. New ATP binds to the Myosin head, causing a detachment of myosin/actin complexes.

11. Hydrolysis ATP form ADP + Pi causing a re-cocking of the Myosin head.. ready for a new cycle.

12. Remaining Ca+ are pump back by ATP and store in SR.

[blessedva]

lecture 10

[mathiasian]

Sounds right to me.

[nauticapnoy12]

This video had helped me to get an A+ on my Physiology class!!!! THANKS CAVEMANI29!!!

[nauticapnoy12]

1. AP moves down axon terminal

2. Exocytosis help release synaptic vesicle containing Ach

3. Ach diffused across the cleft and binds with Ach receptor

4. Ach dependent Na+ channel open up.

[nauticapnoy12]

5. Na+ goes inside cell that brings membrane potential to threshold causing voltage Na+ channel to open up along sarcolemma.

6. Ap travel from sarcolemma to T-tubule, which triggers the release of Ca+ from Sarcoplasmic Reticulum

7. Some Ca+ binds to the Tnc region of the troponin, which shift the troponin, thus removing the blockade in actin.

8. Myosin head combine with ADP+Pi binds to actin.

[nauticapnoy12]

9. Myosin head pull actin towards the center of sarcomere and ADP + Pi releases from Myosin head.

10. New ATP binds to the Myosin head, causing a detachment of myosin/actin complexes.

11. Hydrolysis ATP form ADP + Pi causing a re-cocking of the Myosin head.. ready for a new cycle.

12. Remaining Ca+ are pump back by ATP and store in SR.

[ppd2000]

my exam is in 14 hours, this will greatly help!

[tomharris22]

haha mines in 30, helpful video!

[GauntV]

mine is in 3 muaahaha

[tlast2012dude]

i study this just because i like it o.0

[roxsanaines]

mine is tomorrow, jajjajaj...

very good video!!!!

[piruvato01]

Yeah!!!!!!

[leticeci]

Jjajajajajaja SABELO PAATIIIIII

[leticeci]

"En respuesta a un cambio de potencial de membrana del musculo se producen pequeñas corrientes intramembrana que atribuye a los sensores de voltaje del mecanismo de acoplamiento"

Catedra de Biofisica.

Facultad de Medicina.

Mdeo. Uruguay.

[leticeci]

I LOVVEEE YOOOUUUUU

[nauticapnoy12]

1. AP moves down axon terminal

2. Exocytosis release synaptic vesicle containing Ach

3. Ach diffuse across the cleft and binds with Ach receptor

4. Ach dependent Na+ channel open up.

[nauticapnoy12]

5. Na+ goes inside cell that brings membrane potential to threshold or depolarize causing voltage Na+ channel to open up along sarcolemma.6. Ap travel from sarcolemma to T-tubule, which triggers the release of Ca+ from Sarcoplasmic Reticulum

7. Some Ca+ binds to the Tnc region of the troponin, which shift the troponin, thus removing the blockade in actin.

8. Myosin head combine with ADP+Pi binds to actin.

[nauticapnoy12]

9. Myosin head pull actin towards the center of sarcomere and ADP + Pi releases from Myosin head.

10. New ATP binds to the Myosin head, causing a detachment of myosin/actin complexes.

11. Hydrolysis ATP form ADP + Pi causing a re-cocking of the Myosin head.. ready for a new cycle.

12. Remaining Ca+ are pump back by ATP and store in SR.

[basithry]

thats a useful video, but i was looking for any video about "Muscle Fatigue" and types of muscle fibers....(type 1 and type 2A,2B)

Please let me know, if anyone of you know the link...

TFS

[missingkeys09]

Thank You! Thanks to you,  I just may have it! You rock!

[nauticapnoy12]

When neural activity stops, SR accumulates the remaining Ca++ which is the reasons why our muscle relax. However the return of Ca++ to the sarcoplasmic reticulum involves active transport which requires Hydrolysis of ATP. Therefore, when we say we are Relax, we are not really relax because when our muscle relax after contraction it still uses Hydrolysis ATP!!!!! yippppie!!!

[riv864]

AWESOME THANK YOU VERY MUCH !!!!

[onizzi]

inglesi non si capisce un cazzo manco dai disegni!!!

[IwantOutt]

THANK YOU THANK YOU THANK YOU !!

[Taveren22]

You ever wonder if we too are just a cog wheel in a machine (body) so enormous, we are like particles on a cell for comparison. The planets' orbits are just like an atom. Hell, the mapping of our Universe looks like cell membranes. Do our cells ponder their existence in some way? Like I am doing now.

[ExNihiloJimmy]

The planets orbits are not just like atoms. That idea is just to give you an visual perspective

[SoraTakenouchi16]

pplanets orbits aren´t like atoms,in fact,they don´t even have the same "behavior" in nature

[hotdawg471]

chill

[lilypaaad]

im failing.

[masternate61]

me too

[confloben]

Nice, contains all the important features!!

[richwaight]

This was such a great video! Loved it.

The molecular machinery (spp?) is such a beautiful process.

If only I had this stuff at Uni... The essays expalining this stuff would have been soooooo much eaiser....

[hotdawg471]

awesome!

[Grak70]

How would we test your hypothesis? That is, what observations about a soul could we observe that would confirm this? Occam's Razor should make it clear that this is an unnecessary duplication. You err in first assuming that a soul's exists and then trying to explain it. This is backwards. First you observe, then you explain.

[Cherri59]

I beg to differ, just a little. A person dreams inspire action. What was considered science fiction at one time is now our reality. That was attained through inspiration. I don't think treasuredragon has a hypothesis...he has an inspiration. Maybe, someday, someone will discover a way to observe and test this unprovable possibility.

[Grak70]

Cherri, I think you missed my point. I'm not saying people should not dream or imagine or come up with new ideas. What I *am* saying is that presupposing the truth of your inspiration without any evidence (or even testability) is backward thinking; you have made too many assumptions from the start.

[MRKetter81]

Which begs the question.. How are you not presupposing as well?

Skepticism presupposes negatives as apposed to positives, so from the get go you find your self running in to a brick wall when it comes to transcendentals.

Leave philosophy to philosophy majors. Science is a poor approach to the claims you're making.

No one is outside of making assumptions. Your brain is constantly filling in the blanks, so your point is pretty moot.

[Grak70]

Why do I need to consider transcendentals at all? If they don't physically manifest there is no good reason for complicating the assumptions I do have to make by assuming they exist without evidence.

Skepticism does not embrace negative positions when positive ones come up empty. It -rejects- the positive positions as unverified. There is a difference between asserting a negative and rejecting a positive.

And damn, has this post-modernist bullcrap taken over youtube lately or something? lol

[MRKetter81]

You can't reject negative or positive it's physiologically impossible.

It's like "willing" electrons not to act like electrons. Which is why skepticism = fail

From a materialistic stand point it contradticts it self.

Now you can ignore transcendentals, but by using "logic" you're using one.

[Grak70]

"You can't reject negative or positive it's physiologically impossible.

It's like "willing" electrons not to act like electrons. Which is why skepticism = fail"

What the hell are you talking about? Why would you believe something you have no reason to believe? Belief doesn't dictate reality, only what you are aware of. Electrons didn't "not exist" because nobody knew about it them in the 18th century.

And -logic- is not transcendent. Read your CARM garbage more carefully next time.

[MRKetter81]

Then define what ARE the laws of logic then?

How are you going to do that considering you'll be entering in to circular reasoning to do so, which logic prohibits.

[Grak70]

Logic is a system for determining if something is true -within the scope of the logic system-. I don't know if it's occurred to you or not, but there are several types of logic and logic systems. We use syllogistic logic to argue positions because we have to employ language.

The logical absolutes are: A=A, A!=(!A), A XOR !A

I don't have to justify these, I am ASSERTING them. If you want to call that "faith" fine, but my assertions are backed up by results. Logic works, wish-thinking doesn't.

[MRKetter81]

"I don't have to justify these, I am ASSERTING them. If you want to call that "faith" fine, but my assertions are backed up by results. Logic works, wish-thinking doesn't."

So in one thing you say by faith you "assert" logic. Well it seems you entered in to circular arguement once again.

I can "ASSERT" something as much as I like, but that doesn't MAKE it logical. I also agree.. wishful thinking doesn't work. I dont believe things I do based on wishful thinking as you "assert".

[Grak70]

I didn't assert logic. I asserted the logical absolutes. There is a difference. That a thing is what it is and is not what it is not and is either what it is or not are concepts that you also accept and that everyone -must- accept to discuss or conceive of anything.

If you want to claim that this means I have accepted a transcendent truth, fine. But given that there are no counter-examples in any facet of existence that we know of, I'd say I'm on pretty solid ground.

[Grak70]

"I can "ASSERT" something as much as I like, but that doesn't MAKE it logical."

Here you presuppose logic. Since my assertions are the foundational axioms of logic, your criticism fails. True, other assertions may be inconsistent with logic...these CANNOT be because logic is contingent upon them.

There is nothing wrong with asserting an axiom -provided you test your assertion and discard it when it fails.-

I also think you and I may have very different definitions of "faith".

[MRKetter81]

I presuppose logic because an axiom falls to peaces if it contradicts the system you use to "assert" it.

You're making a giant circular arguement wich folds in on it self.

Try again.

[wickedimpulse]

Jesus.

You're just throwing random large words together to make this horrible frankenstein of an idea that does't make any sense. It's like you took a thesaurus (yet still managed to mangle the spelling), half a semester of junior college Philosophy 101, and a Terence McKenna book, then threw them in a blender. Then, I presuppose you took this Thing That Should Not Be, funneled it into your ass, and sprayed it all over YouTube.

[MRKetter81]

Thanks for no real point at all as usual.

[brentEApower]

@Grak70

Are you responding to the Action Potential animation? Your comments don't make any sense in the context of this animation.

[Grak70]

@brentEApower Considering I made those comments more than 11 months ago, I'm not surprised it doesn't make contextual sense. MRK was talking about how action potential "proves" there is a soul. Hilarity ensued, comments were jumbled, others will be blamed...

[RoniDream]

@Grak70

dragon is definitely working under the hypothesis with assumption that souls exist. Which is not entirely un-scientific as long as he/she can prove that it's all consistent.

If [soul exists], can it be in the form of [AP]; and if so, such and such would happen [then demostrate it].

as long as it doesn't come back to bite in the form of circular reasoning XD

[mvadla]

very very handy explanation, ty :D

[shep59]

is modulating the concentration of ATP part of this process? it seems like it would be inefficient just to have the tropomyosin acting like a clutch, while the myosin is always ready to go.

[fidelyo123]

howcome this vid doesnt mention anything about releasing calcium ions,ligand gated channels or voltage gated calcium ions?..or is that for the action potential of a nerve cell?...kinda lost...someone plz help i have a quiz and a test soon!

[Sleepless0in0Riyadh]

breeeast>>

Muscle Relaxation is explained in the same clip...

if u noticed something called Cholinestrase which degrades Ach so Na\K channels are closed ..thats means the Muscle stop contracting which means Muscle Relaxation!!!

[rockbottom612]

great video

[SuperiorSavior]

Great explanation, shame about the ecchoy voice.

[fasoolatido]

finallyyy! great video.

[caramunda]

cool

[sukalubov666]

Awesome! Thank you!

[ColdLazarus12]

That is one of the better animations I've seen.  Thanks for posting.

[potat3o]

I sometimes wonder if this is all a big lie .... I mean, where do they come up with this stuff. Oh well, better start memorizing.

[minmum]

NICE

[u4w51]

goooooooooooooooooood