is it not also possible that a intra-molecular reaction occurs but instead the nucleophillic alpha carbon and the electrophillic carbonyl carbon are coming from different molecules? when is it favorable to form rings? i'm guessing that a 5 carbon ring is the lowest and that if where only were 3 carbons between the carbonyl groups the intra-molecular reaction wouldn't take place as the 4 carbon ring that would be formed isn't stable enough?
If the nucleoplilic alpha carbon and the electrophilic carbonyl are coming from different molecules you can't call it a intra-molecular reaction anymore, but instead it's a INTER-molecular reaction. Anyhow, I think it's possible. But forming a ring has it's advantage. 6 carbon ring is the most stable. 5 is less stable, and 3 and 4 even less. But, there's also another factor important here: ENTROPY.
with intramolecular ring formation, what's important is the kinetics. As the 5 member ring forms faster than the 6 member ring, it forms before the 6 member ring has a chance to form.
@999Leon999 wrong. intramolecular applies to one molecule. intermolecular involves more than one molecule.
"Intramolecular in chemistry describes a process or characteristic limited within the structure of a single molecule; a property or phenomenon limited to the extent of a single molecule."
Part 2 of my reaction : Going from 2 molecule to 1 molecule is loss of entropy, but when you have an intramolecular reaction you go from 1 molecule to 1, therefore no loss of entropy.
Thank you sir. You have done a superb job. I don't think I need to know retro Aldol Condensation rxn just the forward one.
Moalta07 7 months ago
I don't normally comment at all! but this video makes me feel like I'M SMART!!!!!!
yukapion 9 months ago
Great vidio
gwk4657 9 months ago
This guys is PIMP
RobT89 1 year ago
is it not also possible that a intra-molecular reaction occurs but instead the nucleophillic alpha carbon and the electrophillic carbonyl carbon are coming from different molecules? when is it favorable to form rings? i'm guessing that a 5 carbon ring is the lowest and that if where only were 3 carbons between the carbonyl groups the intra-molecular reaction wouldn't take place as the 4 carbon ring that would be formed isn't stable enough?
Dreadin88 2 years ago
If the nucleoplilic alpha carbon and the electrophilic carbonyl are coming from different molecules you can't call it a intra-molecular reaction anymore, but instead it's a INTER-molecular reaction. Anyhow, I think it's possible. But forming a ring has it's advantage. 6 carbon ring is the most stable. 5 is less stable, and 3 and 4 even less. But, there's also another factor important here: ENTROPY.
999Leon999 2 years ago
with intramolecular ring formation, what's important is the kinetics. As the 5 member ring forms faster than the 6 member ring, it forms before the 6 member ring has a chance to form.
sfcsarah 2 years ago
@999Leon999 wrong. intramolecular applies to one molecule. intermolecular involves more than one molecule.
"Intramolecular in chemistry describes a process or characteristic limited within the structure of a single molecule; a property or phenomenon limited to the extent of a single molecule."
Vudar 1 year ago
@Vudar How is what he said wrong? You basically summarized his post.
JRockey0915 9 months ago
Part 2 of my reaction : Going from 2 molecule to 1 molecule is loss of entropy, but when you have an intramolecular reaction you go from 1 molecule to 1, therefore no loss of entropy.
999Leon999 2 years ago