Mayo Clinic Study Finds Parkinson's Disease Medication Triggers Destructive Behavior

[freedpatriots]

Thank you for bringing this to the General Pubic's attention. As a PD patient I was prescribed a Dopamine Agonist (MIrapex) for fourteen years. My current neurologist has titrated me off. HE SAVED MY LIFE !. I am now experiencing Dopamine Agonist Withdrawal Syndrome- for 4 months now, had to be put on anti-seizure medication to cope.Considering taking this medication ? I strongly recommend you google DAWS. Compulsive Disorders ruin lives and can cause death, suicide, and major injuries, caution!

[socius8]

@freedpatriots My father was prescribed a Dopamine antagonist as well. he experienced severe hallucinations.

[sharkeywicks]

answers to questions about parkinsons on wellsphere

[sharkeywicks]

@sharkeywicks I can't seem to go get a reply to my questions about if Q10 works with or against the drugs Ropinirole and Sinemet . Also, I don't see any questions about heavy metal and there relationship to my Parkinsons like symtoms. May I get a reply please. Thank You.

[anuketscrusade]

given that the general public's perception of ALL people with PD is likely to be negatively influenced by this, i find it irresponsible of the Mayo Clinic to broadcast this to the world but decline to answer questions about it.

[bobulli]

My 4th try at making another comment, to say that this conversation continues at NeuroTalk Communities, sub-section Parkinson`s

[bobulli]

This is social media, right? I sent you the URL of the conversations about your study. Hello? Is there a problem ?

[anuketscrusade]

i am re-posting my comments:

1) I beg everyone who sees this to read the actual study - not just the abstract, the whole study it can be found online, google mayo clinic proceedings bostwick and it will be the top item the pramipexole (Mirapex) package insert can be found at drugs@fda and search on pramipexole - check my facts, please!!

[anuketscrusade]

2) For 4 out of 7 patients, there is no stated temporal relationship btw initiation/increase or cessation/decrease in dopamine agonists & certain behavior in the absence of a temporal relationship, on what basis are you claiming the existence of an association between the drug and the behavior?

[anuketscrusade]

3) 2 out of those 4, in addition to having no stated temporal relationship, are footnoted as not clearly pathologic well, you cant have your cake and eat it too  if they arent pathologic, then they are not eligible for inclusion in a study with pathological as an inclusion criterion

[anuketscrusade]

4) you define 2mg/day or greater as therapeutic dosage of pramipexole but according to the package insert, doses of 3 mg, 4.5 mg, and 6 mg per day of MIRAPEX tablets were not shown to provide any significant benefit beyond that achieved at a daily dose of 1.5 mg/day. So, actually, less than 2mg/day is definitely therapeutic.

[anuketscrusade]

5) You exclude 28 of the 66 people taking agonists on the basis of this never before heard and according to the package insert completely erroneous categorization of their agonist dosage as subtherapeutic.

[anuketscrusade]

6) If you remove the patients who were included without any basis for inclusion, and include those who were excluded without any basis for exclusion, you get 3 patients out of 66 taking dopamine agonists who experienced compulsive behavior, which indicates a prevalence of 4.5%, or approximately ¼ that which you are claiming to have found.

[bobulli]

You know, you say in the video that you did not even meet or talk to or listen to any Parkinson's patients in doing your research about Parkinson's disease, and Anuket, who has Parkinson's, writes in to contradict your research, and you delete all her posts. We are so, so very accustomed to being treated like that. Let's see now, one in 5 - that's 300,000 hypersexial gamblers. Where are they? I have met 300 Parkies. And did not get laid. Find me the 20%

[bobulli]

And I will be supporting Anuket at my site, parkinsons dance at blogspot. There are about 300 of us here and we all have Parkinson's, and we are very very tired of being told we are the ones who have to whisper.

[anuketscrusade]

anyone who reads this before they delete it, i raised several questions about this study and posted them here a day or two ago. rather than addressing them, they have deleted them. i will be posting the same questions and several additional issues on my blog anukets crusade.

[bobulli]

Of 1,500,000 Americans with Parkinson's, how many gambling, sex-crazed Parkies did you find? You say one in five people... and you say you found SEVEN PEOPLE who, knowing they have a fatal disease, go nuts on gambling and drugs and sex. Now it is harder for us to get jobs, apartments, bank loans, because the press have run wild with this exciting story, that drugs-crazed Parkie gamblers are not to be trusted.

[HappyandBetFree]

1 in 5 an UNDERESTEMENT?