Tuberculosis Protein: Key to Understanding "Gene Switch"

[gadionson1]

new idea...good!!!

[al7o6i]

Thanks for the useful description ...

[artsyred]

O.K., if you figure out the 'on' state the of tuberculosis protein can you then figure out ways to release it from the body? Would this eliminate immunizations? Or...am I way off base here? Thanks again!

[davidtravisg]

Hey, thanks for watching and thinking about it and for your questions. Sorry it took me so long to answer, I didn't know I'd have to register; now onboard. Once we figure out the 'on' state, its still a tough problem, because it is inside the TB cell, which is burrowed inside a human cell (so evil!). But at least we'll have a better idea of how it works... --dtg

[WeskerUmbrella4]

so if you figure out "on" and off" state of that TB protein,maybe you can develop some kinda of cure that disables that "on" state so that it doesn't switch on the genes and disables that signal?but this just an idea,maybe a longshot...thanks

[Diabolous3x]

ur a bit off base - the idea is that this is protein is a vital part of the machinery of the bacteria 'mycobacterium tuberculosis'. Because of this protein being unique to the bacteria, it is possible to use this to our advantage for the possibility of developing certain drugs to alter the protein in some way such that its rendered obsolete and causes the break down of the bacteria's ability to switch on 'genes that it needs to survive'. Or we could harness the protein to deliver a drug...

[artsyred]

Wow...just fabulous David! Do I completely understand it all, not exactly. I would be lying if I said I did. But I will investigate this more to try. It sometimes takes my Really Right-Sided artistic brain a while to grasp this stuff! Thanks again~Janet

[usnistgov]

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