How your memory work?

[doctorw2]

learning something new increases your intelligence by leaps and bounds.

[7466309change]

great way to get people drink milk.

[DalianDK]

how the fuck have people figured stuff like this out?

[freyajean]

@DalianDK they studied

[returnoftheramble]

regardless of interference, it works fine because I adapted like a deaf person. Now hand over the job.

[Vodazvezda]

*Wants longer video* ~.~

[kosec321]

So, thank's to the video, and the uploader I understand how i can learn, but how does alzheimer's desease effect this process ? I wan't to see how a brain of a person who has alzheimers works, or atleast an explanation, can someone answer my question please.

[Vodazvezda]

@kosec321 Me, too.

[ilveroskleri]

and what about Ras-ERK pathway?

[philliesorca]

i have a strange memory. my brain tends to store useless info; example, as a matter of fact, i can remember what i was doing 1 year ago today, and its totally useless information.

[Evidentz07]

Wow...it sort of stops abruptly before it gets to the important information. There is so much more that happens, specifically with the NMDA receptors, the binding of Calcium ions and CAM-KII, and CAM-KII's role in 'inserting' new AMPA receptors into the post synaptic membrane. Since more AMPA receptors are inserted, that means the release of glutamate will produce a greater EPSP (thus a greater synaptic connection). It also failed to mention Nitric Oxide Synthase!

[Tearjerker88]

what confuses me is the fact that calcium ions play a crucial role in initiating PREsynaptic processes in neurotransmitter release. This is the first video that tells a slightly different story: they are involved in strengthening the connections. Btw, the NMDA receptor is a receptor sensitive specifically to glutamate. This certainly is the most common excitatory neurotransmitter, but the fact is that there are more than 60 reported naturally occurring neurotransmitters in the human brain.

[max1511]

..u cant follow calcium role...is so confusing! Calcium added on solution is involved(a desensitive process!) by membrane(immunofluorescence)an­d create a "wave" inside the cell!u can saw massive calcium release by internal stores! how it work?why?what's the function?where?it's only transduction signal..or exist direct action too??!! i left my university laboratory whit so many questions..but all was so amazing!!! lol!!

[EikeKehrel]

nice animation but what the video is says is all wrong or unprecise - it's bad to give incomplete information. this is spam ! it's noble spam but it's still spam. explain the NMDA receptor and the concept of reinforcement of synaptic connections - where is the rest ?? it doesn't make sence this way. now people think calcium = memory. it's funny but I I think everybody would be much more excited by the whole mecchanism

[DJuggz06]

The entire mechanism is hugely complex, Im flat out understanding the parts that we do know about, and i've been studying it for 3 years.

But i agree with you, I would be more excited to see the entire mechanism, down to the molecular level, of how memory is formed and maintained.

[JohnGee1977]

"Sence" is SENSE and "mecchanism" is MECHANISM...

[EikeKehrel]

thanks a lot. I'am a german guy living in italy and writing in english so sometimes I become a 'bit confused. mechanism in italian si spelled "meccanismo" so you might understand. "sence" is just a bad mistake. hopefully your lesson will stay in my memory. I think I'll have a glass of milk right now

[GetTheCans]

@EikeKehrel I don't think so, but then, when we explain things we really dance the fine line between giving all the necessary information and not giving so much information that the listener stops listening.

[EikeKehrel]

@GetTheCans of course if you are talking to a child or to somebody who doesn't know anything about the topic it might be reasonable to use a simple language and allways be carefull not to give too much information which might cause CONFUSION (check out Feynman about confusion :) !) but what they do in this video is different: they give WRONG information. of coarse Ca is crucial in the entire machanism but not more than Mg or Na or whatever is swimming around there ...

[EikeKehrel]

@GetTheCans and then suddenly when they are supposed to go to the heart of the question the video just stops.. they should talk about at least two things: 1) our memory seems to be contained in the STRENGTH OF CONNECTION between thousands of neurons: if the connections are strong then you remember, if the connections are week then you tend to loose your information. starting at this point (which is probably very very oversimlified) there arises one question: 2) with the stuff our brain is made

[EikeKehrel]

@GetTheCans off , how is it possible to build a mechanism with these properties ? ... well, one of them is the NMDA-receptor ! nobody knows everything about this receptor but one sweet crucial detail has been discovered:

There are two cells A and B where A sends a signal to cell B. according to what we said before, the connection between cell A and cell B must become stronger once the signal passes from A to B. the trick is, that cell B starts to do a lot of funny things once it has been...

[EikeKehrel]

@GetTheCans stimulated sufficiently such as producing NO (nitricoxide) which is a very small tiny little molecule than can defuse in all directions and also BACK to cell A where it induces a couple of reactions which will make it easier for cell A to eccite cell B next time. in other words there must be a "loop" or a feedback or whatever you want to call it.. ...and so on and so on.. .. .. I don't think this was too complicated and it much more focuses on the important parts of this topic . this

[EikeKehrel]

@GetTheCans is the most simple and elementary way to start a discussion about this topic. later on you can talk about Ca and intracellular pathways, wired potentials and unexpected discoveries making things incredibly complex. but what you can NOT do is starting everything talking about Ca. .. cazz.. when you try to explain someone the rules of soccer you don't spend the first 15min talking about all sorts of grass

[azharoslan]

@EikeKehrel noble spam? lol ur a genius!!

[rollinherbelli]

Calcium doesn't just flow through this receptor. The NMDA receptor is usually blocked by a magnesium ion and has to be ejected through depolarization....

[razz732]

milk is bad...casein.

[EikeKehrel]

that's interesting ! ... what's the problem about casein ?

[xoxAngelFirexox]

idk why but the human brain and development always fascinated me

Aside from it looking like a bowl of worms that is, lol. It's just crazy to think about.....

No wonder I have such good memory at times.... I take vitamins every day and I love milk haha

[Oneworld87]

Where's the rest?

[masterducky1]

so saying if we could put calcium in are brain to every part we will know every thing

[ariainvictus]

What is the name of the full video that this clip is taken from?

[diman500]

very interesting

[tkandme]

so if i drink a lot of milk and take my vitamins everyday, then i will remember stuff better?

[GetTheCans]

Healthy Body = Healthy Mind.

[returnoftheramble]

@GetTheCans not if it's maladaptive or overly stressed of fatigued. It's just like exercise; do it wrong, be broken not strong.

[clanOT]

we are talking about extemely small amounts of calcium. far more would be used for bones/teeth and muscles

[cracky2001]

interesting teaching presented in a boring, uncatchy manner

[ImaSumac4ever]

I'm talking calcium every day starting now!

[Ashfaf]

i le it

[dattuvindya]

could u please post more of the video? much obliged

[thoughtwaretv]

great. Please post the whole thing.

[1krys07]

could u please post more of the video? much obliged

[farch27]

its so intresting but,how can i have the whole movie

[sinankosak]

nice animations but why did you cut exacly where the story begins?. :( too short to understand how memory works.